M0 acute myeloid leukemia (M0-AML)
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| Written | 1999-12 | Jean-Loup Huret |
| Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France | ||
| Updated | 2002-05 | Marie Christine Bene |
| Laboratoire d'Immunologie du CHU, Faculté de Médecine de Nancy, BP 184, 54500 Vandoeuvre les Nancy, France |
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1. Identity
| ICD-Topo | C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS |
| ICD-Morpho | 9861/3 AML with mutated NPM1; AML with mutated CEBPA; Acute myeloid leukaemia, NOS |
| ICD-Morpho | 9872/3 AML with minimal differentiation; Myeloid sarcoma |
| Atlas_Id | 1057 |
| Note | Stasi's criteria |
| Other names | Minimally differentiated acute leukemia |
2. Clinics and Pathology
| Epidemiology | rare: 3 - 5 % of AML; med age 45 yrs; 20% are children; unbalanced sex ratio in the adults: 1.6 M/1F, p |
| Clinics | High WBC mostly in children; frequently low Hb and platelets; organomegaly in children |
| Cytology | Undifferentiated blasts, cytochemistry: negative for myeloperoxydase. Positivity of at least one myeloid marker (CD13, CD33, CD65, CD117-c-KIT). Frequent expression of early progenitor markers CD34, DR; TdT in 30-40% of the cases; CD7 expression frequent in children. MPO antigen identified in about 50% of the cases. |
| Prognosis | Poor: CR in 50% of cases, med survival: 8 mths Poor prognosis factors: older age, high WBC, low platelets, CD10, CD14, CD15. |
3. Cytogenetics
| Cytogenetics Morphological | high percentage of complex (20%) and unbalanced karyotypes; partial or complete monosomy (5/del(5q, -7/del(7q), or rearrangements of chromosome 5 and/or 7 in 15-20%; chromosome 11 rearrangements (11q23 in particular), and chromosome 8 involvement (+8) in 10-15%; chromosome 13 involvement ( +13) in 9% ;t(9;22)(q34;q11) in 5%; near-tetraploidy in 6%; normal karyotype in 25% |
4. Bibliography
| Acute myeloid leukaemia M0: haematological, immunophenotypic and cytogenetic characteristics and their prognostic significance: an analysis in 241 patients. |
| Béné MC, Bernier M, Casasnovas RO, Castoldi G, Doekharan D, van der Holt B, Knapp W, Lemez P, Ludwig WD, Matutes E, Orfao A, Schoch C, Sperling C, van't Veer MB |
| British journal of haematology. 2001 ; 113 (3) : 737-745. |
| PMID 11380465 |
| The immunophenotype of minimally differentiated acute myeloid leukemia (AML-M0): reduced immunogenicity and high frequency of CD34+/CD38- leukemic progenitors. |
| Costello R, Mallet F, Chambost H, Sainty D, Arnoulet C, Gastaut JA, Olive D |
| Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 1999 ; 13 (10) : 1513-1518. |
| PMID 10516751 |
| AML-M0: a review of laboratory features and proposal of new diagnostic criteria. |
| Stasi R, Amadori S |
| Blood cells, molecules & diseases. 1999 ; 25 (2) : 120-129. |
| PMID 10389594 |
5. Citation
| This paper should be referenced as such : |
| Bene, MC |
| M0 acute non lymphocytic leukemia (M0-AML) |
| Atlas Genet Cytogenet Oncol Haematol. 2002;6(3):226-226. |
| Free journal version : [ pdf ] [ DOI ] |
| On line version : http://atlasgeneticsoncology.usal.es/classic/Anomalies/M0ANLLID1057.html |
| History of this paper: |
| Huret, JL. M0 acute non lymphocytic leukemia (M0-AML). Atlas Genet Cytogenet Oncol Haematol. 1999;3(4):202-202. |
| http://documents.irevues.inist.fr/bitstream/handle/2042/37564/12-1999-M0AMLID1057.pdf |
6. External links
| REVIEW articles | automatic search in PubMed |
| Last year articles | automatic search in PubMed |
| All articles | automatic search in PubMed |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Wed Nov 28 16:17:20 CET 2018 |
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