Atlas of Genetics and Cytogenetics in Oncology and Haematology

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t(1;2)(q21;p23) TPM3/ALK

Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)


Atlas_Id 3379
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

Clinics and Pathology

Disease Anaplastic large cell lymphoma, systemic type

Genes involved and Proteins

Gene NameTPM3
Location 1q21.3
Gene NameALK
Location 2p23.2


A new fusion gene TPM3-ALK in anaplastic large cell lymphoma created by a (1;2)(q25;p23) translocation
Lamant L, Dastugue N, Pulford K, Delsol G, Mariamé B
Blood 1999 May 1;93(9):3088-95
PMID 10216106
Complex variant translocation t(1;2) with TPM3-ALK fusion due to cryptic ALK gene rearrangement in anaplastic large-cell lymphoma
Siebert R, Gesk S, Harder L, Steinemann D, Grote W, Schlegelberger B, Tiemann M, Wlodarska I, Schemmel V
Blood 1999 Nov 15;94(10):3614-7
PMID 10610119
5'-(RACE) identification of rare ALK fusion partner in anaplastic large cell lymphoma
Reading NS, Jenson SD, Smith JK, Lim MS, Elenitoba-Johnson KS
J Mol Diagn 2003 May;5(2):136-40
PMID 12707379

Translocations implicated (Data extracted from papers in the Atlas)

 t(1;2)(q21;p23) TPM3/ALK

External links

TPM3 (1q21.3) ALK (2p23.2)

Mitelman databaset(1;2)(q21;p23) [Case List]    t(1;2)(q21;p23) [Transloc-MCList] TPM3/ALK [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed

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indexed on : Wed Nov 28 16:20:11 CET 2018

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