t(6;12)(q22;p13) ETV6/FRK

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Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

1. Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 2705
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

2. Clinics and Pathology

Disease Acute myelomonocytic leukemia (FAB type M4)

3. Genes involved and Proteins

Gene NameETV6
Location 12p13.2
Gene NameFRK
Location 6q22.1

4. Bibliography

Identification of a SRC-like tyrosine kinase gene, FRK, fused with ETV6 in a patient with acute myelogenous leukemia carrying a t(6;12)(q21;p13) translocation
Hosoya N, Qiao Y, Hangaishi A, Wang L, Nannya Y, Sanada M, Kurokawa M, Chiba S, Hirai H, Ogawa S
Genes Chromosomes Cancer 2005 Mar;42(3):269-79
PMID 15611931
 


5. Translocations implicated (Data extracted from papers in the Atlas)

 t(6;12)(q22;p13) ETV6/FRK

6. External links

ETV6 (12p13.2) FRK (6q22.1)

Mitelman databaset(6;12)(q22;p13) [Case List]    t(6;12)(q22;p13) [Transloc-MCList] ETV6/FRK [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
 
 
REVIEW articlesautomatic search in PubMed
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indexed on : Wed Nov 28 16:21:49 CET 2018

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