t(9;16)(p24;p13) CIITA/PDCD1LG2

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Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

1. Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 2607
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

2. Clinics and Pathology

Disease Mediastinal large B-cell lymphoma

3. Genes involved and Proteins

Gene NameCIITA
Location 16p13.13
Gene NamePDCD1LG2
Location 9p24.1

4. Bibliography

MHC class II transactivator CIITA is a recurrent gene fusion partner in lymphoid cancers
Steidl C, Shah SP, Woolcock BW, Rui L, Kawahara M, Farinha P, Johnson NA, Zhao Y, Telenius A, Neriah SB, McPherson A, Meissner B, Okoye UC, Diepstra A, van den Berg A, Sun M, Leung G, Jones SJ, Connors JM, Huntsman DG, Savage KJ, Rimsza LM, Horsman DE, Staudt LM, Steidl U, Marra MA, Gascoyne RD
Nature 2011 Mar 17;471(7338):377-81
PMID 21368758
 


5. Translocations implicated (Data extracted from papers in the Atlas)

 t(9;16)(p24;p13) CIITA/PDCD1LG2

6. External links

CIITA (16p13.13) PDCD1LG2 (9p24.1)

Mitelman databaset(9;16)(p24;p13) [Case List]    t(9;16)(p24;p13) [Transloc-MCList] CIITA/PDCD1LG2 [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
 
 
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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 28 16:22:40 CET 2018

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