t(11;15)(q23;q14) KMT2A/KNL1

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Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

1. Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 3476
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

2. Clinics and Pathology

Disease Acute myeloblastic leukemia with maturation (FAB type M2)

3. Genes involved and Proteins

Gene NameKMT2A
Location 11q23.3
Gene NameKNL1
Location 15q15.1

4. Bibliography

Immunophenotype of adult and childhood acute promyelocytic leukaemia: correlation with morphology, type of PML gene breakpoint and clinical outcome
Guglielmi C, Martelli MP, Diverio D, Fenu S, Vegna ML, Cantù-Rajnoldi A, Biondi A, Cocito MG, Del Vecchio L, Tabilio A, Avvisati G, Basso G, Lo Coco F
A cooperative Italian study on 196 cases Br J Haematol
 


5. Translocations implicated (Data extracted from papers in the Atlas)

 t(11;15)(q23;q14) KMT2A/KNL1

6. External links

KMT2A (11q23.3) KNL1 (15q15.1)

Mitelman databaset(11;15)(q23;q14) [Case List]    t(11;15)(q23;q14) [Transloc-MCList] KMT2A/KNL1 [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
 
 
REVIEW articlesautomatic search in PubMed
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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 28 16:23:17 CET 2018

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