t(11;15)(q23;q21) KMT2A/TCF12

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Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

1. Identity

ICD-Topo C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS
Atlas_Id 2900
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

2. Clinics and Pathology

Disease Refractory anemia with ringed sideroblasts

3. Genes involved and Proteins

Gene NameKMT2A
Location 11q23.3
Gene NameTCF12
Location 15q21.3

4. Bibliography

A complex MLL rearrangement identified five years after initial MDS diagnosis results in out-of-frame fusions without progression to acute leukemia
Meyer C, Kowarz E, Yip SF, Wan TS, Chan TK, Dingermann T, Chan LC, Marschalek R
Cancer Genet 2011 Oct;204(10):557-62
PMID 22137486
 


5. Translocations implicated (Data extracted from papers in the Atlas)

 t(11;15)(q23;q21) KMT2A/TCF12

6. External links

KMT2A (11q23.3) TCF12 (15q21.3)

Mitelman databaset(11;15)(q23;q21) [Case List]    t(11;15)(q23;q21) [Transloc-MCList] KMT2A/TCF12 [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
 
 
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed


© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 28 16:23:18 CET 2018

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