t(14;19)(q32;q13) IGH/BCL3

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Written2018-01Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

1. Identity

Atlas_Id 3489
Note Non-annotated chromosomal abnormality. Preliminary data :
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2. Clinics and Pathology

Disease Bilineage or biphenotypic leukemia|Chronic lymphocytic leukemia|Diffuse large B-cell lymphoma|Follicular lymphoma|Hodgkin disease, NOS|Mature B-cell neoplasm, NOS|Nodal marginal zone B-cell lymphoma|Splenic marginal zone B-cell lymphoma

3. Genes involved and Proteins

Gene NameIGH
Location 14q32.33
Gene NameBCL3
Location 19q13.32

4. Bibliography

Interphase detection of immunoglobulin heavy chain gene translocations with specific oncogene loci in 173 patients with B-cell lymphoma
Tamura A, Miura I, Iida S, Yokota S, Horiike S, Nishida K, Fujii H, Nakamura S, Seto M, Ueda R, Taniwaki M
Cancer Genet Cytogenet 2001 Aug;129(1):1-9
PMID 11520558
Bcl-3/IgH translocation (14;19)(q32;q13) in non-Hodgkin's lymphomas
Au WY, Horsman DE, Ohno H, Klasa RJ, Gascoyne RD
Leuk Lymphoma 2002 Apr;43(4):813-6
PMID 12153169
Splenic small B-cell lymphoma with IGH/BCL3 translocation
Soma LA, Gollin SM, Remstein ED, Ketterling RP, Flynn HC, Rajasenan KK, Swerdlow SH
Hum Pathol 2006 Feb;37(2):218-30
PMID 16426923
B-cell non-Hodgkin's lymphoma: evidence for the t (14;18) translocation in all hematopoietic cell lineages
Yarkoni S, Lishner M, Tangi I, Nagler A, Lorberboum-Galski H
J Natl Cancer Inst 1996 Jul 17;88(14):973-9
PMID 8667428
A comprehensive genetic and histopathologic analysis identifies two subgroups of B-cell malignancies carrying a t(14;19)(q32;q13) or variant BCL3-translocation
Martín-Subero JI, Ibbotson R, Klapper W, Michaux L, Callet-Bauchu E, Berger F, Calasanz MJ, De Wolf-Peeters C, Dyer MJ, Felman P, Gardiner A, Gascoyne RD, Gesk S, Harder L, Horsman DE, Kneba M, Küppers R, Majid A, Parry-Jones N, Ritgen M, Salido M, Solé F, Thiel G, Wacker HH, Oscier D, Wlodarska I, Siebert R
Leukemia 2007 Jul;21(7):1532-44
PMID 17495977
BCL2 and BCL3 are recurrent translocation partners of the IGH locus
Szymanowska N, Klapper W, Gesk S, Küppers R, Martín-Subero JI, Siebert R
Cancer Genet Cytogenet 2008 Oct 15;186(2):110-4
PMID 18940474
Translocation (14;19) in acute biphenotypic leukemia
Carter R, Dubé I, McKeithan T, Carstairs K, DeHarven E, Bailey D, Scott JG
Cancer Genet Cytogenet 1991 May;53(1):67-73
PMID 1903671
Identification of a transcriptional unit adjacent to the breakpoint in the 14;19 translocation of chronic lymphocytic leukemia
McKeithan TW, Ohno H, Diaz MO
Genes Chromosomes Cancer 1990 Jan;1(3):247-55
PMID 2083219
Cloning and sequencing of a t(14;19) breakpoint that involves the C mu switch region
Crossen PE, Kennedy MA, Heaton DC, Morrison MJ
Genes Chromosomes Cancer 1993 Sep;8(1):60-2
PMID 7691160
Molecular characterization of the t(14;19)(q32;q13) translocation in chronic lymphocytic leukemia
Ohno H, Doi S, Yabumoto K, Fukuhara S, McKeithan TW
Leukemia 1993 Dec;7(12):2057-63
PMID 8255106

5. Translocations implicated (Data extracted from papers in the Atlas)

 t(14;19)(q32;q13) IGH/BCL3

6. External links

IGH (14q32.33) BCL3 (19q13.32)

Mitelman databaset(14;19)(q32;q13) [Case List]    t(14;19)(q32;q13) [Transloc-MCList] IGH/BCL3 [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
arrayMap (UZH-SIB Zurich)[select an item]
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed

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indexed on : Wed Nov 28 16:23:57 CET 2018

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