t(15;21)(q24;q22) RUNX1/SIN3A

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Written2018-01Jean-Loup Huret, Philippe Dessen

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1. Identity

Atlas_Id 3178
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

2. Clinics and Pathology

Disease Chronic myelomonocytic leukemia

3. Genes involved and Proteins

Gene NameRUNX1
Location 21q22.12
Gene NameSIN3A
Location 15q24.2

4. Bibliography

t(15;21) translocations leading to the concurrent downregulation of RUNX1 and its transcription factor partner genes SIN3A and TCF12 in myeloid disorders
L'Abbate A, Tolomeo D, De Astis F, Lonoce A, Lo Cunsolo C, Mühlematter D, Schoumans J, Vandenberghe P, Van Hoof A, Palumbo O, Carella M, Mazza T, Storlazzi CT
Mol Cancer 2015 Dec 16;14:211
PMID 26671595

5. Translocations implicated (Data extracted from papers in the Atlas)

 t(15;21)(q24;q22) RUNX1/SIN3A

6. External links

RUNX1 (21q22.12) SIN3A (15q24.2)

Mitelman databaset(15;21)(q24;q22) [Case List]    t(15;21)(q24;q22) [Transloc-MCList] RUNX1/SIN3A [Fusion-MCList]
COSMICHisto = - Site = haematopoietic_and_lymphoid_tissue (COSMIC)
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REVIEW articlesautomatic search in PubMed
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indexed on : Wed Nov 28 16:24:01 CET 2018

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