t(1;6)(p35;p25) ?/IRF4

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Written2005-01Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

(Note : for Links provided by Atlas : click)

1. Identity

Atlas_Id 1378
  t(1;6)(p35;p25) G- banding - top: Courtesy Melanie Zenger and Claudia Haferlach; bottom Courtesy Aurelia Meloni-Ehrig.

2. Clinics and Pathology

Disease Chronic lymphocytic leukemia (CLL)
Phenotype / cell stem origin Unmutated status of IgVH (an unfavourable prognostic feature) was found in all cases.
Epidemiology 8 patients to date, representing 0.5% of CLL cases in a country based survey; sex ratio: 6 male/2 female patients, aged 33-81 years (med: 62.5 years).
Clinics Two cases in Binet stage A, 4 in stage B, 2 in stage C. Normal LDH values in 7 of 8.
Prognosis Yet unknown (median follow up is only 28 months), but 3 patients developed a diffuse large B-cell lymphoma (DLBCL), and 3 patients (2 of which with DLBCL) died at 29, 76, and 95 months.

3. Cytogenetics

Additional anomalies Sole anomaly in three cases, with +12 in three cases, with 9q anomalies in three, del(11q) in two, 17p anomalies in two, 17q anomalies in two; del(11q), and 17p anomalies are poor prognostic factors in CLL.

4. Genes involved and Proteins

Note IRF4 (6p25.2) is possibly involved in the translocation. The gene in 1p35.3 is unknown.

5. To be noted

6. Bibliography

Translocation t(1;6)(p35.3;p25.2): a new recurrent aberration in unmutated B-CLL.
Michaux L, Wlodarska I, Rack K, Stul M, Criel A, Maerevoet M, Marichal S, Demuynck H, Mineur P, Kargar Samani K, Van Hoof A, Ferrant A, Marynen P, Hagemeijer A
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 2005 ; 19 (1) : 77-82.
PMID 15510210

7. Citation

This paper should be referenced as such :
Huret, JL
Atlas Genet Cytogenet Oncol Haematol. 2005;9(1):28-29.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://atlasgeneticsoncology.usal.es/classic/Anomalies/t0106p35p25ID1378.html

8. Translocations implicated (Data extracted from papers in the Atlas)

 t(1;6)(p35;p25) ?/IRF4

9. External links

Mitelman databaset(1;6)(p35;p25) [Case List]    t(1;6)(p35;p25) [Transloc-MCList] ?/IRF4 [Fusion-MCList]
arrayMap (UZH-SIB Zurich)[select an item]
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed

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indexed on : Wed Nov 28 16:17:40 CET 2018

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