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Written2008-12Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers; CHU Poitiers Hospital, F-86021 Poitiers, France

(Note : for Links provided by Atlas : click)

1. Identity

ICD-Morpho 9920/3 Therapy-related myeloid neoplasms
ICD-Morpho 9989/3 Myelodysplastic syndrome, unclassifiable
Atlas_Id 1530

2. Clinics and Pathology

Disease Myelodysplastic syndromes (MDS) and acute myeloid leukaemia (AML), but also chronic lymphoproliferative diseases (CLD)
Phenotype / cell stem origin The MDS case was a refractory anaemia with ringed sideroblasts (RARS), the AML case was a treatment related leukaemia (t-AML) (Hirst et al., 1993; Olney et al., 2002). The two CLD cases were chronic lymphocytic leukaemia (CLL) cases, one of which being atypical (Datta et al., 1991; Martin-Subero et al., 2007). This translocation is likely to be heterogenous.
Epidemiology Only four cases to date; the case with RARS was a 72-year-old male patient, the t-AML case was also a male patient; the CLL cases (1 male and 1 female patients) were aged 35 and 75.
Prognosis No data.

3. Cytogenetics

Cytogenetics Morphological Sole anomaly in one myeloid and one lymphoid case, accompanied with del(11q) and del(13q) in the RARS, and +12, and t(14;19)(q32;q13) with IgH/BCL3 rearrangement in one CLL case.

4. Genes involved and Proteins

Note Genes involved are unknown.

5. To be noted

Additional cases are needed to delineate the epidemiology of this rare entity:
you are welcome to submit a paper to our new Case Report section.

6. Bibliography

Chromosome analyses in chronic lymphocytic leukemia and related B-cell neoplasms.
Datta T, Bauchinger M, Emmerich B, Reichle A.
Cancer Genet Cytogenet. 1991 Aug;55(1):49-56.
PMID 1913607
Consistent interstitial chromosomal deletions in myeloid malignancies and their correlation with fragile sites.
Hirst WJ, Czepulkowski B, Mufti GJ.
Cancer Genet Cytogenet. 1993 Jan;65(1):51-7.
PMID 8431916
A comprehensive genetic and histopathologic analysis identifies two subgroups of B-cell malignancies carrying a t(14;19)(q32;q13) or variant BCL3-translocation.
Martin-Subero JI, Ibbotson R, Klapper W, Michaux L, Callet-Bauchu E, Berger F, Calasanz MJ, De Wolf-Peeters C, Dyer MJ, Felman P, Gardiner A, Gascoyne RD, Gesk S, Harder L, Horsman DE, Kneba M, Kuppers R, Majid A, Parry-Jones N, Ritgen M, Salido M, Sole F, Thiel G, Wacker HH, Oscier D, Wlodarska I, Siebert R.
Leukemia. 2007 Jul;21(7):1532-44. Epub 2007 May 10.
PMID 17495977
Unique balanced chromosome abnormalities in treatment-related myelodysplastic syndromes and acute myeloid leukemia: report from an international workshop.
Olney HJ, Mitelman F, Johansson B, Mrozek K, Berger R, Rowley JD.
Genes Chromosomes Cancer. 2002 Apr;33(4):413-23.
PMID 11921275

7. Citation

This paper should be referenced as such :
Huret, JL
Atlas Genet Cytogenet Oncol Haematol. 2009;13(11):881-881.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://atlasgeneticsoncology.usal.es/classic/Anomalies/t0106p36p21ID1530.html

8. Translocations implicated (Data extracted from papers in the Atlas)


9. External links

Mitelman databaset(1;6)(p36;p21) [Case List]    t(1;6)(p36;p21) [Transloc-MCList]
arrayMap (UZH-SIB Zurich)Topo ( C42) Morph ( 9920/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
arrayMap (UZH-SIB Zurich)Topo ( C42) Morph ( 9989/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed

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indexed on : Wed Nov 28 16:17:40 CET 2018

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