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Written2000-02Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

(Note : for Links provided by Atlas : click)

1. Identity

ICD-Morpho 9861/3 AML with mutated NPM1; AML with mutated CEBPA; Acute myeloid leukaemia, NOS
Atlas_Id 1318
  t(1;16)(q12;q24) Fluorescence in situ hybridization with Vysis LSI 1p36/LSI 1q25 dual-color probe (Abbott molecular, US) showing extra copy of 1q25 on metaphase with der(16)t(1;16) (green signal on der(16) chromosome) – Courtesy Adriana Zamecnikova.

2. Clinics and Pathology

Disease Acute myeloid leukemia (AML)
Note poorly known: only 2 cases to date
Phenotype / cell stem origin a case of Fanconi anemia and a case of M1-AML
Epidemiology The Fanconi anemia patient was a 9 yr old girl, and the AML case was a 22 yr old male patient
Prognosis unknown

3. Cytogenetics

Cytogenetics Morphological The t(1;16) presented as a der(16)t(1;16) in the 2 cases, resulting in trisomy 1q. The t(1;16) was the sole anomaly in each case.

4. To be noted

Additional cases are needed to delineate the epidemiology of this rare entity:
you are welcome to submit a paper to our new Case Report section.

5. Bibliography

Fluorescence in situ hybridization analysis of chromosome 1 abnormalities in hematopoietic disorders: rearrangements of DNA satellite II and new recurrent translocations.
Busson-Le Coniat M, Salomon-Nguyen F, Dastugue N, Maarek O, Lafage-Pochitaloff M, Mozziconacci MJ, Baranger L, Brizard F, Radford I, Jeanpierre M, Bernard OA, Berger R
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 1999 ; 13 (12) : 1975-1981.
PMID 10602418

6. Citation

This paper should be referenced as such :
Huret, JL
Atlas Genet Cytogenet Oncol Haematol. 2000;4(1):30-30.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://atlasgeneticsoncology.usal.es/classic/Anomalies/t0116q12q24ID1318.html

7. Translocations implicated (Data extracted from papers in the Atlas)


8. External links

Mitelman databaset(1;16)(q12;q24) [Case List]    t(1;16)(q12;q24) [Transloc-MCList]
arrayMap (UZH-SIB Zurich)Topo ( C42) Morph ( 9861/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed

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indexed on : Wed Nov 28 16:17:49 CET 2018

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