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Written2007-08Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

(Note : for Links provided by Atlas : click)

1. Identity

ICD-Morpho 9861/3 AML with mutated NPM1; AML with mutated CEBPA; Acute myeloid leukaemia, NOS
ICD-Morpho 9920/3 Therapy-related myeloid neoplasms
Atlas_Id 1288

2. Clinics and Pathology

Disease Acute myeloid leukaemia (AML)
Phenotype / cell stem origin One de novo AML (M2 type), and a therapy related AML (t-AML)
Epidemiology The de novo AML was a 11 year old girl; the t-AML case was a 58 year old female patient who had been treated for ovary carcinoma with melphalan 1.5 yrs before.
Prognosis No complete remission (CR) in the de novo case; CR was obtained but a relapse occurred and the patient died 3 months after diagnosis in the therapy related case.

3. Cytogenetics

Cytogenetics Morphological Sole anomaly in the de novo AML case; complex karyotype in the t-AML case, with -5 and other abnormalities

4. Genes involved and Proteins

Note Genes involved are unknown.

5. To be noted

Additional cases are needed to delineate the epidemiology of this rare entity:
you are welcome to submit a paper to our new Case Report section.

6. Bibliography

Short remission durations in therapy-related leukemia despite cytogenetic complete responses to high-dose cytarabine.
Larson RA, Wernli M, Le Beau MM, Daly KM, Pape LH, Rowley JD, Vardiman JW
Blood. 1988 ; 72 (4) : 1333-1339.
PMID 3167210
Translocation t(2;19)(p11;p12-p13) in childhood with acute myeloid leukemia.
Quilichini B, Zattara H, Cas E, BastideAlliez LA, Blachere A, Curtillet C, Fossat C, Michel G
Atlas Genet Cytogenet Oncol Haematol. 2003 ; 7 (numero 1) : 137-140.

7. Citation

This paper should be referenced as such :
Huret, JL
Atlas Genet Cytogenet Oncol Haematol. 2008;12(4):346-346.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://atlasgeneticsoncology.usal.es/classic/Anomalies/t0219p11p13ID1288.html

8. Translocations implicated (Data extracted from papers in the Atlas)


9. External links

Mitelman databaset(2;19)(p11;p13) [Case List]    t(2;19)(p11;p13) [Transloc-MCList]
arrayMap (UZH-SIB Zurich)Topo ( C42) Morph ( 9861/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
arrayMap (UZH-SIB Zurich)Topo ( C42) Morph ( 9920/3) -   [auto + random 100 samples .. if exist ]   [tabulated segments]
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed
All articlesautomatic search in PubMed

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 28 16:18:03 CET 2018

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