t(3;14)(p14;q32) IGH/FOXP1
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Written | 2005-07 | Jean-Loup Huret |
Genetics, Dept Medical Information, University of Poitiers; CHU Poitiers Hospital, F-86021 Poitiers, France |
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1. Identity
ICD-Topo | C420,C421,C424 BLOOD, BONE MARROW, & HEMATOPOIETIC SYS |
Atlas_Id | 1398 |
2. Clinics and Pathology
Disease | Extra-nodal Marginal Zone B-cell lymphoma (MZBCL) of mucosa-associated lymphoid tissue (MALT) type, also called MALT lymphoma |
Note | MALT lymphomas without the t(3;14) are frequently associated with either a t(1;14)(p22;q32) ( BCL10 / IGH), a t(11;18)(q21;q21) ( API2 / MALT1, or a t(14;18)(q32;q21) (IGH/MALT1) |
Epidemiology | 9 cases detected to date |
Clinics | MALT lymphoma is an indolent disease involving most often the stomach, the lung, the thyroid, the salivary gland, the orbit, and the skin, with a non random anatomic distribution according to the translocation. The t(3;14) is frequently found in MALT lymphomas of the thyroid, the orbit, and the skin. |
3. Cytogenetics
Additional anomalies | +3 is found in half cases |
4. Genes involved and Proteins
Gene Name | FOXP1 (Forkhead box P1) |
Location | 3p13 |
Protein | Transcription factor; member of the FOXP subfamily, characterized by a DNA binding forkhead. |
Gene Name | IGH (Immunoglobulin Heavy) |
Location | 14q32.33 |
5. Result of the chromosomal anomaly
Description | Breakpoint upstream the first 5' non coding exon of FOXP1 |
6. To be noted
Additional cases are needed to delineate the epidemiology of this rare entity: you are welcome to submit a paper to our new Case Report section. |
7. Bibliography
T(3;14)(p14.1;q32) involving IGH and FOXP1 is a novel recurrent chromosomal aberration in MALT lymphoma. |
Streubel B, Vinatzer U, Lamprecht A, Raderer M, Chott A |
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 2005 ; 19 (4) : 652-658. |
PMID 15703784 |
8. Citation
This paper should be referenced as such : |
Huret, JL |
t(3;14)(p14;q32) |
Atlas Genet Cytogenet Oncol Haematol. 2005;9(4):327-327. |
Free journal version : [ pdf ] [ DOI ] |
On line version : http://atlasgeneticsoncology.usal.es/classic/Anomalies/t0314p14q32ID1398.html |
9. Translocations implicated (Data extracted from papers in the Atlas)
10. External links
REVIEW articles | automatic search in PubMed |
Last year articles | automatic search in PubMed |
All articles | automatic search in PubMed |
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