The immunophilin-like protein XAP2 is a negative regulator of estrogen signaling through interaction with estrogen receptor α. |
Cai W, Kramarova TV, Berg P, Korbonits M, Pongratz I. |
PLoS One. 2011;6(10):e25201. doi: 10.1371/journal.pone.0025201. Epub 2011 Oct 3. |
PMID 21984905 |
|
Ligand-dependent interaction of the aryl hydrocarbon receptor with a novel immunophilin homolog in vivo. |
Carver LA, Bradfield CA. |
J Biol Chem. 1997 Apr 25;272(17):11452-6. |
PMID 9111057 |
|
Germline AIP mutations in apparently sporadic pituitary adenomas: prevalence in a prospective single-center cohort of 443 patients. |
Cazabat L, Bouligand J, Salenave S, Bernier M, Gaillard S, Parker F, Young J, Guiochon-Mantel A, Chanson P. |
J Clin Endocrinol Metab. 2012 Apr;97(4):E663-70. doi: 10.1210/jc.2011-2291. Epub 2012 Feb 8. |
PMID 22319033 |
|
Germline inactivating mutations of the aryl hydrocarbon receptor-interacting protein gene in a large cohort of sporadic acromegaly: mutations are found in a subset of young patients with macroadenomas. |
Cazabat L, Libe R, Perlemoine K, Rene-Corail F, Burnichon N, Gimenez-Roqueplo AP, Dupasquier-Fediaevsky L, Bertagna X, Clauser E, Chanson P, Bertherat J, Raffin-Sanson ML. |
Eur J Endocrinol. 2007 Jul;157(1):1-8. |
PMID 17609395 |
|
Clinical, genetic and molecular characterization of patients with familial isolated pituitary adenomas (FIPA). |
Chahal HS, Chapple JP, Frohman LA, Grossman AB, Korbonits M. |
Trends Endocrinol Metab. 2010 Jul;21(7):419-27. doi: 10.1016/j.tem.2010.02.007. Epub 2010 Jun 1. (REVIEW) |
PMID 20570174 |
|
AIP mutation in pituitary adenomas in the 18th century and today. |
Chahal HS, Stals K, Unterlander M, Balding DJ, Thomas MG, Kumar AV, Besser GM, Atkinson AB, Morrison PJ, Howlett TA, Levy MJ, Orme SM, Akker SA, Abel RL, Grossman AB, Burger J, Ellard S, Korbonits M. |
N Engl J Med. 2011 Jan 6;364(1):43-50. doi: 10.1056/NEJMoa1008020. |
PMID 21208107 |
|
Clinical characteristics and therapeutic responses in patients with germ-line AIP mutations and pituitary adenomas: an international collaborative study. |
Daly AF, Tichomirowa MA, Petrossians P, Heliovaara E, Jaffrain-Rea ML, Barlier A, Naves LA, Ebeling T, Karhu A, Raappana A, Cazabat L, De Menis E, Montanana CF, Raverot G, Weil RJ, Sane T, Maiter D, Neggers S, Yaneva M, Tabarin A, Verrua E, Eloranta E, Murat A, Vierimaa O, Salmela PI, Emy P, Toledo RA, Sabate MI, Villa C, Popelier M, Salvatori R, Jennings J, Longas AF, Labarta Aizpun JI, Georgitsi M, Paschke R, Ronchi C, Valimaki M, Saloranta C, De Herder W, Cozzi R, Guitelman M, Magri F, Lagonigro MS, Halaby G, Corman V, Hagelstein MT, Vanbellinghen JF, Barra GB, Gimenez-Roqueplo AP, Cameron FJ, Borson-Chazot F, Holdaway I, Toledo SP, Stalla GK, Spada A, Zacharieva S, Bertherat J, Brue T, Bours V, Chanson P, Aaltonen LA, Beckers A. |
J Clin Endocrinol Metab. 2010 Nov;95(11):E373-83. doi: 10.1210/jc.2009-2556. Epub 2010 Aug 4. |
PMID 20685857 |
|
Aryl hydrocarbon receptor-interacting protein gene mutations in familial isolated pituitary adenomas: analysis in 73 families. |
Daly AF, Vanbellinghen JF, Khoo SK, Jaffrain-Rea ML, Naves LA, Guitelman MA, Murat A, Emy P, Gimenez-Roqueplo AP, Tamburrano G, Raverot G, Barlier A, De Herder W, Penfornis A, Ciccarelli E, Estour B, Lecomte P, Gatta B, Chabre O, Sabate MI, Bertagna X, Garcia Basavilbaso N, Stalldecker G, Colao A, Ferolla P, Wemeau JL, Caron P, Sadoul JL, Oneto A, Archambeaud F, Calender A, Sinilnikova O, Montanana CF, Cavagnini F, Hana V, Solano A, Delettieres D, Luccio-Camelo DC, Basso A, Rohmer V, Brue T, Bours V, Teh BT, Beckers A. |
J Clin Endocrinol Metab. 2007 May;92(5):1891-6. Epub 2007 Jan 23. |
PMID 17244780 |
|
Mutation analysis of aryl hydrocarbon receptor interacting protein (AIP) gene in colorectal, breast, and prostate cancers. |
Georgitsi M, Karhu A, Winqvist R, Visakorpi T, Waltering K, Vahteristo P, Launonen V, Aaltonen LA. |
Br J Cancer. 2007 Jan 29;96(2):352-6. |
PMID 17242703 |
|
The expression of AIP-related molecules in elucidation of cellular pathways in pituitary adenomas. |
Heliovaara E, Raitila A, Launonen V, Paetau A, Arola J, Lehtonen H, Sane T, Weil RJ, Vierimaa O, Salmela P, Tuppurainen K, Makinen M, Aaltonen LA, Karhu A. |
Am J Pathol. 2009 Dec;175(6):2501-7. doi: 10.2353/ajpath.2009.081131. Epub 2009 Oct 22. |
PMID 19850893 |
|
The aryl hydrocarbon (Ah) receptor transcriptional regulator hepatitis B virus X-associated protein 2 antagonizes p23 binding to Ah receptor-Hsp90 complexes and is dispensable for receptor function. |
Hollingshead BD, Petrulis JR, Perdew GH. |
J Biol Chem. 2004 Oct 29;279(44):45652-61. Epub 2004 Aug 20. |
PMID 15322122 |
|
Developmental control of apoptosis by the immunophilin aryl hydrocarbon receptor-interacting protein (AIP) involves mitochondrial import of the survivin protein. |
Kang BH, Xia F, Pop R, Dohi T, Socolovsky M, Altieri DC. |
J Biol Chem. 2011 May 13;286(19):16758-67. doi: 10.1074/jbc.M110.210120. Epub 2011 Mar 18. |
PMID 21454573 |
|
Low aryl hydrocarbon receptor-interacting protein expression is a better marker of invasiveness in somatotropinomas than Ki-67 and p53. |
Kasuki Jomori de Pinho L, Vieira Neto L, Armondi Wildemberg LE, Gasparetto EL, Marcondes J, de Almeida Nunes B, Takiya CM, Gadelha MR. |
Neuroendocrinology. 2011;94(1):39-48. doi: 10.1159/000322787. Epub 2010 Dec 18. |
PMID 21178332 |
|
Evidence that the co-chaperone p23 regulates ligand responsiveness of the dioxin (Aryl hydrocarbon) receptor. |
Kazlauskas A, Poellinger L, Pongratz I. |
J Biol Chem. 1999 May 7;274(19):13519-24. |
PMID 10224120 |
|
AIP-Related Familial Isolated Pituitary Adenomas. |
Korbonits M, Kumar AV. |
Pagon RA, Bird TD, Dolan CR, Stephens K, Adam MP, editors. Source, GeneReviewsTM [Internet]. Seattle (WA): University of Washington, Seattle; 1993-.2012 Jun 21. |
PMID 22720333 |
|
XAP2, a novel hepatitis B virus X-associated protein that inhibits X transactivation. |
Kuzhandaivelu N, Cong YS, Inouye C, Yang WM, Seto E. |
Nucleic Acids Res. 1996 Dec 1;24(23):4741-50. |
PMID 8972861 |
|
ARA9 modifies agonist signaling through an increase in cytosolic aryl hydrocarbon receptor. |
LaPres JJ, Glover E, Dunham EE, Bunger MK, Bradfield CA. |
J Biol Chem. 2000 Mar 3;275(9):6153-9. |
PMID 10692406 |
|
The role of the aryl hydrocarbon receptor-interacting protein gene in familial and sporadic pituitary adenomas. |
Leontiou CA, Gueorguiev M, van der Spuy J, Quinton R, Lolli F, Hassan S, Chahal HS, Igreja SC, Jordan S, Rowe J, Stolbrink M, Christian HC, Wray J, Bishop-Bailey D, Berney DM, Wass JA, Popovic V, Ribeiro-Oliveira A Jr, Gadelha MR, Monson JP, Akker SA, Davis JR, Clayton RN, Yoshimoto K, Iwata T, Matsuno A, Eguchi K, Musat M, Flanagan D, Peters G, Bolger GB, Chapple JP, Frohman LA, Grossman AB, Korbonits M. |
J Clin Endocrinol Metab. 2008 Jun;93(6):2390-401. doi: 10.1210/jc.2007-2611. Epub 2008 Apr 1. |
PMID 18381572 |
|
Deletion of the aryl hydrocarbon receptor-associated protein 9 leads to cardiac malformation and embryonic lethality. |
Lin BC, Sullivan R, Lee Y, Moran S, Glover E, Bradfield CA. |
J Biol Chem. 2007 Dec 7;282(49):35924-32. Epub 2007 Oct 4. |
PMID 17916558 |
|
Characterization of the AhR-hsp90-XAP2 core complex and the role of the immunophilin-related protein XAP2 in AhR stabilization. |
Meyer BK, Perdew GH. |
Biochemistry. 1999 Jul 13;38(28):8907-17. |
PMID 10413464 |
|
Hepatitis B virus X-associated protein 2 is a subunit of the unliganded aryl hydrocarbon receptor core complex and exhibits transcriptional enhancer activity. |
Meyer BK, Pray-Grant MG, Vanden Heuvel JP, Perdew GH. |
Mol Cell Biol. 1998 Feb;18(2):978-88. |
PMID 9447995 |
|
The aryl hydrocarbon receptor-interacting protein (AIP) is required for dioxin-induced hepatotoxicity but not for the induction of the Cyp1a1 and Cyp1a2 genes. |
Nukaya M, Lin BC, Glover E, Moran SM, Kennedy GD, Bradfield CA. |
J Biol Chem. 2010 Nov 12;285(46):35599-605. doi: 10.1074/jbc.M110.132043. Epub 2010 Sep 9. |
PMID 20829355 |
|
AIP gene and familial isolated pituitary adenomas. |
Ozfirat Z, Korbonits M. |
Mol Cell Endocrinol. 2010 Sep 15;326(1-2):71-9. doi: 10.1016/j.mce.2010.05.001. Epub 2010 May 8. (REVIEW) |
PMID 20457215 |
|
Association of the Ah receptor with the 90-kDa heat shock protein. |
Perdew GH. |
J Biol Chem. 1988 Sep 25;263(27):13802-5. |
PMID 2843537 |
|
Role of endogenous XAP2 protein on the localization and nucleocytoplasmic shuttling of the endogenous mouse Ahb-1 receptor in the presence and absence of ligand. |
Pollenz RS, Wilson SE, Dougherty EJ. |
Mol Pharmacol. 2006 Oct;70(4):1369-79. Epub 2006 Jul 11. |
PMID 16835354 |
|
No evidence of somatic aryl hydrocarbon receptor interacting protein mutations in sporadic endocrine neoplasia. |
Raitila A, Georgitsi M, Karhu A, Tuppurainen K, Makinen MJ, Birkenkamp-Demtroder K, Salmenkivi K, Orntoft TF, Arola J, Launonen V, Vahteristo P, Aaltonen LA. |
Endocr Relat Cancer. 2007 Sep;14(3):901-6. |
PMID 17914118 |
|
Mice with inactivation of aryl hydrocarbon receptor-interacting protein (Aip) display complete penetrance of pituitary adenomas with aberrant ARNT expression. |
Raitila A, Lehtonen HJ, Arola J, Heliovaara E, Ahlsten M, Georgitsi M, Jalanko A, Paetau A, Aaltonen LA, Karhu A. |
Am J Pathol. 2010 Oct;177(4):1969-76. doi: 10.2353/ajpath.2010.100138. Epub 2010 Aug 13. |
PMID 20709796 |
|
High prevalence of AIP gene mutations following focused screening in young patients with sporadic pituitary macroadenomas. |
Tichomirowa MA, Barlier A, Daly AF, Jaffrain-Rea ML, Ronchi C, Yaneva M, Urban JD, Petrossians P, Elenkova A, Tabarin A, Desailloud R, Maiter D, Schurmeyer T, Cozzi R, Theodoropoulou M, Sievers C, Bernabeu I, Naves LA, Chabre O, Montanana CF, Hana V, Halaby G, Delemer B, Aizpun JI, Sonnet E, Longas AF, Hagelstein MT, Caron P, Stalla GK, Bours V, Zacharieva S, Spada A, Brue T, Beckers A. |
Eur J Endocrinol. 2011 Oct;165(4):509-15. doi: 10.1530/EJE-11-0304. Epub 2011 Jul 13. |
PMID 21753072 |
|
AIP and its interacting partners. |
Trivellin G, Korbonits M. |
J Endocrinol. 2011 Aug;210(2):137-55. doi: 10.1530/JOE-11-0054. Epub 2011 Mar 31. (REVIEW) |
PMID 21454441 |
|
Pituitary adenoma predisposition caused by germline mutations in the AIP gene. |
Vierimaa O, Georgitsi M, Lehtonen R, Vahteristo P, Kokko A, Raitila A, Tuppurainen K, Ebeling TM, Salmela PI, Paschke R, Gundogdu S, De Menis E, Makinen MJ, Launonen V, Karhu A, Aaltonen LA. |
Science. 2006 May 26;312(5777):1228-30. |
PMID 16728643 |
|