ADAMTS16 (ADAM metallopeptidase with thrombospondin type 1 motif 16)

1. Identity

Alias_names
General Information
Alias_symbol (synonym)ADAMTS16s
Other alias
HGNC (Hugo) ADAMTS16
LocusID (NCBI) 170690
Atlas_Id 47206
Location 5p15.32  [Link to chromosome band 5p15]
Location_base_pair Starts at 5140330 and ends at 5320302 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ADAMTS16 (5p15.32) / ETV6 (12p13.2)MRPS28 (8q21.13) / ADAMTS16 (5p15.32)SRD5A1 (5p15.31) / ADAMTS16 (5p15.32)
ADAMTS16 5p15.32 / ETV6 12p13.2SRD5A1 5p15.31 / ADAMTS16 5p15.32

2. DNA/RNA

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 4 ]
  Lung: Translocations in Squamous Cell Carcinoma
SRD5A1/ADAMTS16 (5p15)
t(5;8)(p15;q21) MRPS28/ADAMTS16
t(5;12)(p15;p13) ADAMTS16/ETV6

3. External links

Nomenclature
HGNC (Hugo)ADAMTS16   17108
Cards
Entrez_Gene (NCBI)ADAMTS16  170690  ADAM metallopeptidase with thrombospondin type 1 motif 16
AliasesADAMTS16s
GeneCards (Weizmann)ADAMTS16
Ensembl hg19 (Hinxton)ENSG00000145536 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000145536 [Gene_View] &nbspENSG00000145536 [Sequence]  chr5:5140330-5320302 [Contig_View]  ADAMTS16 [Vega]
ICGC DataPortalENSG00000145536
TCGA cBioPortalADAMTS16
AceView (NCBI)ADAMTS16
Genatlas (Paris)ADAMTS16
WikiGenes170690
SOURCE (Princeton)ADAMTS16
Genetics Home Reference (NIH)ADAMTS16
Genomic and cartography
GoldenPath hg38 (UCSC)ADAMTS16  -     chr5:5140330-5320302 +  5p15.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ADAMTS16  -     5p15.32   [Description]    (hg19-Feb_2009)
EnsemblADAMTS16 - 5p15.32 [CytoView hg19]  ADAMTS16 - 5p15.32 [CytoView hg38]
Mapping of homologs : NCBIADAMTS16 [Mapview hg19]  ADAMTS16 [Mapview hg38]
OMIM607510   
Gene and transcription
Genbank (Entrez)AB095949 AJ315734 AK122980 AK127746 AM983533
RefSeq transcript (Entrez)NM_139056
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ADAMTS16
Cluster EST : UnigeneHs.661915 [ NCBI ]
CGAP (NCI)Hs.661915
Alternative Splicing GalleryENSG00000145536
Gene ExpressionADAMTS16 [ NCBI-GEO ]   ADAMTS16 [ EBI - ARRAY_EXPRESS ]   ADAMTS16 [ SEEK ]   ADAMTS16 [ MEM ]
Gene Expression Viewer (FireBrowse)ADAMTS16 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets] &nbsp [Normal Tissue Atlas] &nbsp[carcinoma Classsification] &nbsp[NCI60]
GenevestigatorExpression in : [tissues] &nbsp[cell-lines] &nbsp[cancer] &nbsp[perturbations] &nbsp
BioGPS (Tissue expression)170690
GTEX Portal (Tissue expression)ADAMTS16
Human Protein AtlasENSG00000145536-ADAMTS16 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8TE57   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8TE57  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8TE57
Splice isoforms : SwissVarQ8TE57
Catalytic activity : Enzyme3.4.24.- [ Enzyme-Expasy ]   3.4.24.-3.4.24.- [ IntEnz-EBI ]   3.4.24.- [ BRENDA ]   3.4.24.- [ KEGG ]   
PhosPhoSitePlusQ8TE57
Domaine pattern : Prosite (Expaxy)ADAM_MEPRO (PS50215)    PLAC (PS50900)    TSP1 (PS50092)   
Domains : Interpro (EBI)ADAM_spacer1    MetalloPept_cat_dom_sf    Peptidase_M12B    Peptidase_M12B_N    PLAC    TSP1_rpt    TSP1_rpt_sf   
Domain families : Pfam (Sanger)ADAM_spacer1 (PF05986)    Pep_M12B_propep (PF01562)    PLAC (PF08686)    Reprolysin (PF01421)    TSP_1 (PF00090)   
Domain families : Pfam (NCBI)pfam05986    pfam01562    pfam08686    pfam01421    pfam00090   
Domain families : Smart (EMBL)TSP1 (SM00209)  
Conserved Domain (NCBI)ADAMTS16
DMDM Disease mutations170690
Blocks (Seattle)ADAMTS16
SuperfamilyQ8TE57
Human Protein Atlas [tissue]ENSG00000145536-ADAMTS16 [tissue]
Peptide AtlasQ8TE57
HPRD06331
IPIIPI00386697   IPI00186114   
Protein Interaction databases
DIP (DOE-UCLA)Q8TE57
IntAct (EBI)Q8TE57
FunCoupENSG00000145536
BioGRIDADAMTS16
STRING (EMBL)ADAMTS16
ZODIACADAMTS16
Ontologies - Pathways
QuickGOQ8TE57
Ontology : AmiGObranching involved in ureteric bud morphogenesis  regulation of systemic arterial blood pressure  metalloendopeptidase activity  extracellular region  proteolysis  metal ion binding  male gamete generation  regulation of cilium assembly  
Ontology : EGO-EBIbranching involved in ureteric bud morphogenesis  regulation of systemic arterial blood pressure  metalloendopeptidase activity  extracellular region  proteolysis  metal ion binding  male gamete generation  regulation of cilium assembly  
NDEx NetworkADAMTS16
Atlas of Cancer Signalling NetworkADAMTS16
Wikipedia pathwaysADAMTS16
Orthology - Evolution
OrthoDB170690
GeneTree (enSembl)ENSG00000145536
Phylogenetic Trees/Animal Genes : TreeFamADAMTS16
HOGENOMQ8TE57
Homologs : HomoloGeneADAMTS16
Homology/Alignments : Family Browser (UCSC)ADAMTS16
Gene fusions - Rearrangements
Fusion : MitelmanADAMTS16/ETV6 [5p15.32/12p13.2] &nbsp
Fusion : MitelmanMRPS28/ADAMTS16 [8q21.13/5p15.32] &nbsp[t(5;8)(p15;q21)]  
Fusion : MitelmanSRD5A1/ADAMTS16 [5p15.31/5p15.32] &nbsp[t(5;5)(p15;p15)]  
Fusion PortalADAMTS16 5p15.32 ETV6 12p13.2 BRCA
Fusion PortalSRD5A1 5p15.31 ADAMTS16 5p15.32 LUAD
Fusion : QuiverADAMTS16
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerADAMTS16 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ADAMTS16
dbVarADAMTS16
ClinVarADAMTS16
1000_GenomesADAMTS16 
Exome Variant ServerADAMTS16
ExAC (Exome Aggregation Consortium)ENSG00000145536
GNOMAD BrowserENSG00000145536
Varsome BrowserADAMTS16
Genetic variants : HAPMAP170690
Genomic Variants (DGV)ADAMTS16 [DGVbeta]
DECIPHERADAMTS16 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisADAMTS16 
Mutations
ICGC Data PortalADAMTS16 
TCGA Data PortalADAMTS16 
Broad Tumor PortalADAMTS16
OASIS PortalADAMTS16 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICADAMTS16  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDADAMTS16
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ADAMTS16
DgiDB (Drug Gene Interaction Database)ADAMTS16
DoCM (Curated mutations)ADAMTS16 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ADAMTS16 (select a term)
intoGenADAMTS16
Cancer3DADAMTS16(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607510   
Orphanet
DisGeNETADAMTS16
MedgenADAMTS16
Genetic Testing Registry ADAMTS16
NextProtQ8TE57 [Medical]
TSGene170690
GENETestsADAMTS16
Target ValidationADAMTS16
Huge Navigator ADAMTS16 [HugePedia]
snp3D : Map Gene to Disease170690
BioCentury BCIQADAMTS16
ClinGenADAMTS16
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD170690
Chemical/Pharm GKB GenePA24542
Clinical trialADAMTS16
Miscellaneous
canSAR (ICR)ADAMTS16 (select the gene name)
DataMed IndexADAMTS16
Probes
Litterature
PubMed15 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineADAMTS16
EVEXADAMTS16
GoPubMedADAMTS16
iHOPADAMTS16
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jan 17 17:59:59 CET 2019

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