CYTH2 (cytohesin 2)

1. Identity

Alias_names
General Information
PSCD2
pleckstrin homology, Sec7 and coiled/coil domains 2 (cytohesin-2)
pleckstrin homology, Sec7 and coiled-coil domains 2
Alias_symbol (synonym)CTS18.1
Sec7p-L
ARNO
Sec7p-like
cytohesin-2
Other aliasCTS18
SEC7L
HGNC (Hugo) CYTH2
LocusID (NCBI) 9266
Atlas_Id 50360
Location 19q13.33  [Link to chromosome band 19q13]
Location_base_pair Starts at 48469208 and ends at 48482314 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CYTH2 (19q13.33) / CYTH2 (19q13.33)CYTH2 (19q13.33) / TAF1D (11q21)HLA-B (6p21.33) / CYTH2 (19q13.33)

2. DNA/RNA

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

 


3. External links

Nomenclature
HGNC (Hugo)CYTH2   9502
Cards
Entrez_Gene (NCBI)CYTH2  9266  cytohesin 2
AliasesARNO; CTS18; CTS18.1; PSCD2; 
PSCD2L; SEC7L; Sec7p-L; Sec7p-like; cytohesin-2
GeneCards (Weizmann)CYTH2
Ensembl hg19 (Hinxton)ENSG00000105443 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000105443 [Gene_View] &nbspENSG00000105443 [Sequence]  chr19:48469208-48482314 [Contig_View]  CYTH2 [Vega]
ICGC DataPortalENSG00000105443
TCGA cBioPortalCYTH2
AceView (NCBI)CYTH2
Genatlas (Paris)CYTH2
WikiGenes9266
SOURCE (Princeton)CYTH2
Genetics Home Reference (NIH)CYTH2
Genomic and cartography
GoldenPath hg38 (UCSC)CYTH2  -     chr19:48469208-48482314 +  19q13.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CYTH2  -     19q13.33   [Description]    (hg19-Feb_2009)
EnsemblCYTH2 - 19q13.33 [CytoView hg19]  CYTH2 - 19q13.33 [CytoView hg38]
Mapping of homologs : NCBICYTH2 [Mapview hg19]  CYTH2 [Mapview hg38]
OMIM602488   
Gene and transcription
Genbank (Entrez)AB209573 AF318380 AK091443 AK292405 AK299590
RefSeq transcript (Entrez)NM_004228 NM_017457
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CYTH2
Cluster EST : UnigeneHs.144011 [ NCBI ]
CGAP (NCI)Hs.144011
Alternative Splicing GalleryENSG00000105443
Gene ExpressionCYTH2 [ NCBI-GEO ]   CYTH2 [ EBI - ARRAY_EXPRESS ]   CYTH2 [ SEEK ]   CYTH2 [ MEM ]
Gene Expression Viewer (FireBrowse)CYTH2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets] &nbsp [Normal Tissue Atlas] &nbsp[carcinoma Classsification] &nbsp[NCI60]
GenevestigatorExpression in : [tissues] &nbsp[cell-lines] &nbsp[cancer] &nbsp[perturbations] &nbsp
BioGPS (Tissue expression)9266
GTEX Portal (Tissue expression)CYTH2
Human Protein AtlasENSG00000105443-CYTH2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ99418   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ99418  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ99418
Splice isoforms : SwissVarQ99418
PhosPhoSitePlusQ99418
Domaine pattern : Prosite (Expaxy)PH_DOMAIN (PS50003)    SEC7 (PS50190)   
Domains : Interpro (EBI)PH-like_dom_sf    PH_domain    Sec7_C_sf    Sec7_dom    Sec7_dom_sf   
Domain families : Pfam (Sanger)PH (PF00169)    Sec7 (PF01369)   
Domain families : Pfam (NCBI)pfam00169    pfam01369   
Domain families : Smart (EMBL)PH (SM00233)  Sec7 (SM00222)  
Conserved Domain (NCBI)CYTH2
DMDM Disease mutations9266
Blocks (Seattle)CYTH2
PDB (RSDB)1PBV    1R8M    1R8Q    1R8S    1S9D    4JMI    4JMO    4JWL    4JXH    4L5M    4Z21   
PDB Europe1PBV    1R8M    1R8Q    1R8S    1S9D    4JMI    4JMO    4JWL    4JXH    4L5M    4Z21   
PDB (PDBSum)1PBV    1R8M    1R8Q    1R8S    1S9D    4JMI    4JMO    4JWL    4JXH    4L5M    4Z21   
PDB (IMB)1PBV    1R8M    1R8Q    1R8S    1S9D    4JMI    4JMO    4JWL    4JXH    4L5M    4Z21   
Structural Biology KnowledgeBase1PBV    1R8M    1R8Q    1R8S    1S9D    4JMI    4JMO    4JWL    4JXH    4L5M    4Z21   
SCOP (Structural Classification of Proteins)1PBV    1R8M    1R8Q    1R8S    1S9D    4JMI    4JMO    4JWL    4JXH    4L5M    4Z21   
CATH (Classification of proteins structures)1PBV    1R8M    1R8Q    1R8S    1S9D    4JMI    4JMO    4JWL    4JXH    4L5M    4Z21   
SuperfamilyQ99418
Human Protein Atlas [tissue]ENSG00000105443-CYTH2 [tissue]
Peptide AtlasQ99418
HPRD03925
IPIIPI00015228   IPI00910648   IPI00556147   IPI00103789   IPI00908336   IPI00853301   IPI00853361   
Protein Interaction databases
DIP (DOE-UCLA)Q99418
IntAct (EBI)Q99418
FunCoupENSG00000105443
BioGRIDCYTH2
STRING (EMBL)CYTH2
ZODIACCYTH2
Ontologies - Pathways
QuickGOQ99418
Ontology : AmiGOGolgi membrane  ARF guanyl-nucleotide exchange factor activity  protein binding  cytoplasm  cytosol  plasma membrane  adherens junction  bicellular tight junction  endocytosis  lipid binding  membrane  actin cytoskeleton organization  growth cone  regulation of ARF protein signal transduction  inositol 1,4,5 trisphosphate binding  
Ontology : EGO-EBIGolgi membrane  ARF guanyl-nucleotide exchange factor activity  protein binding  cytoplasm  cytosol  plasma membrane  adherens junction  bicellular tight junction  endocytosis  lipid binding  membrane  actin cytoskeleton organization  growth cone  regulation of ARF protein signal transduction  inositol 1,4,5 trisphosphate binding  
NDEx NetworkCYTH2
Atlas of Cancer Signalling NetworkCYTH2
Wikipedia pathwaysCYTH2
Orthology - Evolution
OrthoDB9266
GeneTree (enSembl)ENSG00000105443
Phylogenetic Trees/Animal Genes : TreeFamCYTH2
HOGENOMQ99418
Homologs : HomoloGeneCYTH2
Homology/Alignments : Family Browser (UCSC)CYTH2
Gene fusions - Rearrangements
Fusion : QuiverCYTH2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCYTH2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CYTH2
dbVarCYTH2
ClinVarCYTH2
1000_GenomesCYTH2 
Exome Variant ServerCYTH2
ExAC (Exome Aggregation Consortium)ENSG00000105443
GNOMAD BrowserENSG00000105443
Varsome BrowserCYTH2
Genetic variants : HAPMAP9266
Genomic Variants (DGV)CYTH2 [DGVbeta]
DECIPHERCYTH2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCYTH2 
Mutations
ICGC Data PortalCYTH2 
TCGA Data PortalCYTH2 
Broad Tumor PortalCYTH2
OASIS PortalCYTH2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCYTH2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCYTH2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CYTH2
DgiDB (Drug Gene Interaction Database)CYTH2
DoCM (Curated mutations)CYTH2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CYTH2 (select a term)
intoGenCYTH2
Cancer3DCYTH2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602488   
Orphanet
DisGeNETCYTH2
MedgenCYTH2
Genetic Testing Registry CYTH2
NextProtQ99418 [Medical]
TSGene9266
GENETestsCYTH2
Target ValidationCYTH2
Huge Navigator CYTH2 [HugePedia]
snp3D : Map Gene to Disease9266
BioCentury BCIQCYTH2
ClinGenCYTH2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9266
Chemical/Pharm GKB GenePA33849
Clinical trialCYTH2
Miscellaneous
canSAR (ICR)CYTH2 (select the gene name)
DataMed IndexCYTH2
Probes
Litterature
PubMed73 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCYTH2
EVEXCYTH2
GoPubMedCYTH2
iHOPCYTH2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Jan 17 18:08:50 CET 2019

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