ERVK-6 (endogenous retrovirus group K member 6, envelope)

1. Identity

Alias_names
General Information
endogenous retroviral sequence K, 6
endogenous retrovirus group K, member 6
Alias_symbol (synonym)HERV-K(HML-2.HOM)
HERV-K108
HERV-K(C7)
Other aliasK-Rev
c-orf
cORF
envK2
HGNC (Hugo) ERVK-6
LocusID (NCBI) 64006
Atlas_Id 40491
Location 7p22.1  [Link to chromosome band 7p22]
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute


2. Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]

3. External links

Nomenclature
HGNC (Hugo)ERVK-6   13915
Cards
Entrez_Gene (NCBI)ERVK-6  64006  endogenous retrovirus group K member 6, envelope
AliasesERVK6; HERV-K(C7); HERV-K108; K-Rev; 
c-orf; cORF; envK2
GeneCards (Weizmann)ERVK-6
Ensembl hg19 (Hinxton) [Gene_View]
Ensembl hg38 (Hinxton) [Gene_View] &nbsp [Sequence]  - [Contig_View]  ERVK-6 [Vega]
TCGA cBioPortalERVK-6
AceView (NCBI)ERVK-6
Genatlas (Paris)ERVK-6
WikiGenes64006
SOURCE (Princeton)ERVK-6
Genetics Home Reference (NIH)ERVK-6
Genomic and cartography
GoldenPath hg38 (UCSC)ERVK-6  -  
GoldenPath hg19 (UCSC)ERVK-6  -  
EnsemblERVK-6 - [CytoView hg19]  ERVK-6 - [CytoView hg38]
Mapping of homologs : NCBIERVK-6 [Mapview hg19]  ERVK-6 [Mapview hg38]
OMIM605626   
Gene and transcription
Genbank (Entrez)AF080233 AY371029 AY371033 AY371034 AY371035
RefSeq transcript (Entrez)NM_001007236
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ERVK-6
Gene ExpressionERVK-6 [ NCBI-GEO ]   ERVK-6 [ EBI - ARRAY_EXPRESS ]   ERVK-6 [ SEEK ]   ERVK-6 [ MEM ]
Gene Expression Viewer (FireBrowse)ERVK-6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets] &nbsp [Normal Tissue Atlas] &nbsp[carcinoma Classsification] &nbsp[NCI60]
GenevestigatorExpression in : [tissues] &nbsp[cell-lines] &nbsp[cancer] &nbsp[perturbations] &nbsp
BioGPS (Tissue expression)64006
GTEX Portal (Tissue expression)ERVK-6
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y6I0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y6I0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y6I0
Splice isoforms : SwissVarQ9Y6I0
Catalytic activity : Enzyme3.4.23.50 [ Enzyme-Expasy ]   3.4.23.503.4.23.50 [ IntEnz-EBI ]   3.4.23.50 [ BRENDA ]   3.4.23.50 [ KEGG ]   
PhosPhoSitePlusQ9Y6I0
Domaine pattern : Prosite (Expaxy)ASP_PROT_RETROV (PS50175)    ASP_PROTEASE (PS00141)    G_PATCH (PS50174)   
Domains : Interpro (EBI)Aspartic_peptidase_AS    G_patch_dom    Peptidase_A2_cat    Peptidase_aspartic_dom_sf    Retropepsin-like_cat_dom    Retropepsins   
Domain families : Pfam (Sanger)G-patch (PF01585)    RVP (PF00077)   
Domain families : Pfam (NCBI)pfam01585    pfam00077   
Domain families : Smart (EMBL)G_patch (SM00443)  
Conserved Domain (NCBI)ERVK-6
DMDM Disease mutations64006
Blocks (Seattle)ERVK-6
SuperfamilyQ9Y6I0
Peptide AtlasQ9Y6I0
HPRD16131
IPIIPI00414890   IPI00414907   IPI00454612   IPI00163885   IPI00452948   IPI00796382   IPI00455074   IPI00456600   IPI00455503   IPI00797185   IPI00856047   IPI00940527   IPI00796023   IPI00848346   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y6I0
IntAct (EBI)Q9Y6I0
BioGRIDERVK-6
STRING (EMBL)ERVK-6
ZODIACERVK-6
Ontologies - Pathways
QuickGOQ9Y6I0
Ontology : AmiGODNA binding  RNA binding  DNA-directed DNA polymerase activity  RNA-directed DNA polymerase activity  aspartic-type endopeptidase activity  RNA-DNA hybrid ribonuclease activity  structural molecule activity  plasma membrane  RNA-dependent DNA biosynthetic process  DNA recombination  proteolysis  zinc ion binding  DNA integration  viral process  RNA phosphodiester bond hydrolysis, endonucleolytic  
Ontology : EGO-EBIDNA binding  RNA binding  DNA-directed DNA polymerase activity  RNA-directed DNA polymerase activity  aspartic-type endopeptidase activity  RNA-DNA hybrid ribonuclease activity  structural molecule activity  plasma membrane  RNA-dependent DNA biosynthetic process  DNA recombination  proteolysis  zinc ion binding  DNA integration  viral process  RNA phosphodiester bond hydrolysis, endonucleolytic  
NDEx NetworkERVK-6
Atlas of Cancer Signalling NetworkERVK-6
Wikipedia pathwaysERVK-6
Orthology - Evolution
OrthoDB64006
Phylogenetic Trees/Animal Genes : TreeFamERVK-6
HOGENOMQ9Y6I0
Homologs : HomoloGeneERVK-6
Homology/Alignments : Family Browser (UCSC)ERVK-6
Gene fusions - Rearrangements
Fusion : QuiverERVK-6
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerERVK-6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ERVK-6
dbVarERVK-6
ClinVarERVK-6
1000_GenomesERVK-6 
Exome Variant ServerERVK-6
Varsome BrowserERVK-6
Genetic variants : HAPMAP64006
Genomic Variants (DGV)ERVK-6 [DGVbeta]
DECIPHERERVK-6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisERVK-6 
Mutations
ICGC Data PortalERVK-6 
TCGA Data PortalERVK-6 
Broad Tumor PortalERVK-6
OASIS PortalERVK-6 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDERVK-6
BioMutasearch ERVK-6
DgiDB (Drug Gene Interaction Database)ERVK-6
DoCM (Curated mutations)ERVK-6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ERVK-6 (select a term)
intoGenERVK-6
Cancer3DERVK-6(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605626   
Orphanet
DisGeNETERVK-6
MedgenERVK-6
Genetic Testing Registry ERVK-6
NextProtQ9Y6I0 [Medical]
TSGene64006
GENETestsERVK-6
Target ValidationERVK-6
Huge Navigator ERVK-6 [HugePedia]
snp3D : Map Gene to Disease64006
BioCentury BCIQERVK-6
ClinGenERVK-6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD64006
Chemical/Pharm GKB GenePA27872
Clinical trialERVK-6
Miscellaneous
canSAR (ICR)ERVK-6 (select the gene name)
DataMed IndexERVK-6
Probes
Litterature
PubMed40 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineERVK-6
EVEXERVK-6
GoPubMedERVK-6
iHOPERVK-6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Jan 17 18:11:38 CET 2019

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