|Written||2010-08||Zhiao Chen, Xianghuo He|
|State Key Laboratory of Oncogenes, Related Genes, Shanghai Cancer Institute, Shanghai, China|
(Note : for Links provided by Atlas : click)
|Location||17p13.3 [Link to chromosome band 17p13]|
|Location_base_pair||Starts at 732546 and ends at 742968 bp from pter ( according to hg19-Feb_2009) [Mapping FAM57A.png]|
|Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)|
|FAM57A (17p13.3) / FAM57A (17p13.3)||PPIF (10q22.3) / FAM57A (17p13.3)|
|Description|| Gene size: 2145 bp in length, ORF 774 bp.|
Full-length cDNA of CT120/FAM57A contains 2145 base pairs and encodes a protein with 257 amino acids.
|Transcription||The CT120 contains two isoforms in human: one isoform identified was termed CT120A; another isoform (AAH26023.1) was named CT120B, which consists of four exons and encodes a protein with 225 amino acids (the fourth exon in CT120A is spliced).|
|Description|| - CT120: 257 aa; 29 kDa. |
- CT120B: 225 aa; 25 kDa.
|Expression||CT120 is universally expressed in different human normal tissues and in various human tumor cell lines.|
|Localisation||CT120 is a novel plasma membrane-associated gene.|
|Function||CT120 may assume very essential physiological functions involving in amino acid transport and glutathione metabolism through interaction with SLC3A2 and GGTL3B.|
|Homology||Homology comparison revealed that CT120 is highly conserved during biological evolution.|
4. Implicated in
|Prognosis|| CT120A protein was a potential molecular target for treatment of lung cancers. CT120A was overexpressed in 15 cases of the 16 primary lung cancer specimens. Knockdown of CT120A by small hairpin RNA in the human lung adenocarcinoma cell line SPC-A-1 cells resulted in a reduced cell growth rate in vitro and decrease of the capacity for anchorage-independent growth and tumorigenicity in nude mice. |
The suppression of CT120A expression also sensitized cells to ultraviolet-induced apoptosis. Atlas cDNA expression array revealed that the expressions of several apoptosis- and growth-associated genes were altered underlying the molecular mechanisms of these cell biological behaviors.
|Oncogenesis|| CT120 ectopic expression could promote cell proliferation activity of NIH3T3 cells, and two major signaling pathways involved in cell proliferation, cell survival and anti-apoptosis were overexpressed and activated in response to CT120: one is the Raf/MEK/Erk signal cascades and the other is the PI3K/Akt signal cascades, suggesting that CT120 might contribute, at least in part, to the constitutively activation of Erk and Akt in human lung cancer cells. |
In addition, some tumor metastasis associated genes cathepsin B, cathepsin D, cathepsin L, MMP-2/TIMP-2 were also upregulated by CT120, upon which CT120 might be involved in tumor invasiveness and metastasis.
In addition, CT120 might play an important role in tumor progression through modulating the expression of some candidate "lung tumor progression" genes including B-Raf, Rab-2, BAX, BAG-1, YB-1 and Cdc42.
|Molecular cloning and characterization of CT120, a novel membrane-associated gene involved in amino acid transport and glutathione metabolism.|
|He X, Di Y, Li J, Xie Y, Tang Y, Zhang F, Wei L, Zhang Y, Qin W, Huo K, Li Y, Wan D, Gu J.|
|Biochem Biophys Res Commun. 2002 Sep 27;297(3):528-36.|
|Altered gene expression profiles of NIH3T3 cells regulated by human lung cancer associated gene CT120.|
|He XH, Li JJ, Xie YH, Tang YT, Yao GF, Qin WX, Wan DF, Gu JR.|
|Cell Res. 2004 Dec;14(6):487-96.|
|Silencing of CT120 by antisense oligonucleotides could inhibit the lung cancer cells growth.|
|Li Z, Shao S, Xie S, Jiao F, Ma Y, Shi S.|
|Ir J Med Sci. 2010 Jun;179(2):217-23. Epub 2009 Dec 20.|
|Down-regulation of CT120A by RNA interference suppresses lung cancer cells growth and sensitizes to ultraviolet-induced apoptosis.|
|Pan D, Wei L, Yao M, Wan D, Gu J.|
|Cancer Lett. 2006 Apr 8;235(1):26-33. Epub 2005 May 31.|
|Inhibitory effect of CT120B, an alternative splice variant of CT120A, on lung cancer cell growth.|
|Pan DN, Li JJ, Wei L, Yao M, Wan DF, Gu JR.|
|Acta Biochim Biophys Sin (Shanghai). 2005 Sep;37(9):588-92.|
|This paper should be referenced as such :|
|Chen, Z ; He, X|
|FAM57A (family with sequence similarity 57, member A)|
|Atlas Genet Cytogenet Oncol Haematol. 2011;15(5):408-409.|
|Free journal version : [ pdf ] [ DOI ]|
|On line version : http://atlasgeneticsoncology.usal.es/classic/Genes/FAM57AID40183ch17p13.html|
7. External links
|REVIEW articles||automatic search in PubMed|
|Last year publications||automatic search in PubMed|
|© Atlas of Genetics and Cytogenetics in Oncology and Haematology||indexed on : Thu Jan 17 18:54:58 CET 2019|
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