FRMD5 (FERM domain containing 5)

1. Identity

Alias_symbol (synonym)
General Information
Other alias-
HGNC (Hugo) FRMD5
LocusID (NCBI) 84978
Atlas_Id 53114
Location 15q15.3  [Link to chromosome band 15q15]
Location_base_pair Starts at 43870761 and ends at 44195294 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FRMD5 (15q15.3) / AGO3 (1p34.3)FRMD5 (15q15.3) / CKAP5 (11p11.2)FRMD5 (15q15.3) / FLNA (Xq28)
MECOM (3q26.2) / FRMD5 (15q15.3)FRMD5 15q15.3 EIF2C3MECOM 3q26.2 / FRMD5 15q15.3

2. DNA/RNA

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(1;15)(p34;q15) FRMD5/AGO3

3. External links

Nomenclature
HGNC (Hugo)FRMD5   28214
Cards
Entrez_Gene (NCBI)FRMD5  84978  FERM domain containing 5
Aliases
GeneCards (Weizmann)FRMD5
Ensembl hg19 (Hinxton)ENSG00000171877 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000171877 [Gene_View] &nbspENSG00000171877 [Sequence]  chr15:43870761-44195294 [Contig_View]  FRMD5 [Vega]
ICGC DataPortalENSG00000171877
TCGA cBioPortalFRMD5
AceView (NCBI)FRMD5
Genatlas (Paris)FRMD5
WikiGenes84978
SOURCE (Princeton)FRMD5
Genetics Home Reference (NIH)FRMD5
Genomic and cartography
GoldenPath hg38 (UCSC)FRMD5  -     chr15:43870761-44195294 -  15q15.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FRMD5  -     15q15.3   [Description]    (hg19-Feb_2009)
EnsemblFRMD5 - 15q15.3 [CytoView hg19]  FRMD5 - 15q15.3 [CytoView hg38]
Mapping of homologs : NCBIFRMD5 [Mapview hg19]  FRMD5 [Mapview hg38]
OMIM616309   
Gene and transcription
Genbank (Entrez)AK090572 AK123018 AK290013 BC007796 BC020191
RefSeq transcript (Entrez)NM_001286490 NM_001286491 NM_001322949 NM_001322950 NM_001322951 NM_032892
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FRMD5
Cluster EST : UnigeneHs.578544 [ NCBI ]
CGAP (NCI)Hs.578544
Alternative Splicing GalleryENSG00000171877
Gene ExpressionFRMD5 [ NCBI-GEO ]   FRMD5 [ EBI - ARRAY_EXPRESS ]   FRMD5 [ SEEK ]   FRMD5 [ MEM ]
Gene Expression Viewer (FireBrowse)FRMD5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets] &nbsp [Normal Tissue Atlas] &nbsp[carcinoma Classsification] &nbsp[NCI60]
GenevestigatorExpression in : [tissues] &nbsp[cell-lines] &nbsp[cancer] &nbsp[perturbations] &nbsp
BioGPS (Tissue expression)84978
GTEX Portal (Tissue expression)FRMD5
Human Protein AtlasENSG00000171877-FRMD5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7Z6J6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7Z6J6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7Z6J6
Splice isoforms : SwissVarQ7Z6J6
PhosPhoSitePlusQ7Z6J6
Domaine pattern : Prosite (Expaxy)FERM_1 (PS00660)    FERM_3 (PS50057)   
Domains : Interpro (EBI)Band_41_domain    Ez/rad/moesin-like    FERM-adjacent    FERM/acyl-CoA-bd_prot_sf    FERM_2    FERM_central    FERM_CS    FERM_domain    FERM_N    FERM_PH-like_C    PH-like_dom_sf    Ubiquitin-like_domsf   
Domain families : Pfam (Sanger)FA (PF08736)    FERM_C (PF09380)    FERM_M (PF00373)    FERM_N (PF09379)   
Domain families : Pfam (NCBI)pfam08736    pfam09380    pfam00373    pfam09379   
Domain families : Smart (EMBL)B41 (SM00295)  FA (SM01195)  FERM_C (SM01196)  
Conserved Domain (NCBI)FRMD5
DMDM Disease mutations84978
Blocks (Seattle)FRMD5
SuperfamilyQ7Z6J6
Human Protein Atlas [tissue]ENSG00000171877-FRMD5 [tissue]
Peptide AtlasQ7Z6J6
HPRD17493
IPIIPI00252153   IPI00414040   IPI00879568   IPI00878322   IPI00878494   IPI00917876   IPI00917174   
Protein Interaction databases
DIP (DOE-UCLA)Q7Z6J6
IntAct (EBI)Q7Z6J6
FunCoupENSG00000171877
BioGRIDFRMD5
STRING (EMBL)FRMD5
ZODIACFRMD5
Ontologies - Pathways
QuickGOQ7Z6J6
Ontology : AmiGOintegrin binding  protein binding  cytoskeleton  adherens junction  cytoskeletal protein binding  integral component of membrane  protein kinase binding  regulation of cell migration  actomyosin structure organization  positive regulation of cell adhesion  negative regulation of cell motility  
Ontology : EGO-EBIintegrin binding  protein binding  cytoskeleton  adherens junction  cytoskeletal protein binding  integral component of membrane  protein kinase binding  regulation of cell migration  actomyosin structure organization  positive regulation of cell adhesion  negative regulation of cell motility  
NDEx NetworkFRMD5
Atlas of Cancer Signalling NetworkFRMD5
Wikipedia pathwaysFRMD5
Orthology - Evolution
OrthoDB84978
GeneTree (enSembl)ENSG00000171877
Phylogenetic Trees/Animal Genes : TreeFamFRMD5
HOGENOMQ7Z6J6
Homologs : HomoloGeneFRMD5
Homology/Alignments : Family Browser (UCSC)FRMD5
Gene fusions - Rearrangements
Fusion : MitelmanFRMD5/AGO3 [15q15.3/1p34.3] &nbsp
Fusion : MitelmanMECOM/FRMD5 [3q26.2/15q15.3] &nbsp[t(3;15)(q26;q15)]  
Fusion PortalFRMD5 15q15.3 EIF2C3 BRCA
Fusion PortalMECOM 3q26.2 FRMD5 15q15.3 LUAD
Fusion : QuiverFRMD5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFRMD5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FRMD5
dbVarFRMD5
ClinVarFRMD5
1000_GenomesFRMD5 
Exome Variant ServerFRMD5
ExAC (Exome Aggregation Consortium)ENSG00000171877
GNOMAD BrowserENSG00000171877
Varsome BrowserFRMD5
Genetic variants : HAPMAP84978
Genomic Variants (DGV)FRMD5 [DGVbeta]
DECIPHERFRMD5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFRMD5 
Mutations
ICGC Data PortalFRMD5 
TCGA Data PortalFRMD5 
Broad Tumor PortalFRMD5
OASIS PortalFRMD5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFRMD5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFRMD5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FRMD5
DgiDB (Drug Gene Interaction Database)FRMD5
DoCM (Curated mutations)FRMD5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FRMD5 (select a term)
intoGenFRMD5
Cancer3DFRMD5(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616309   
Orphanet
DisGeNETFRMD5
MedgenFRMD5
Genetic Testing Registry FRMD5
NextProtQ7Z6J6 [Medical]
TSGene84978
GENETestsFRMD5
Target ValidationFRMD5
Huge Navigator FRMD5 [HugePedia]
snp3D : Map Gene to Disease84978
BioCentury BCIQFRMD5
ClinGenFRMD5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD84978
Chemical/Pharm GKB GenePA142671751
Clinical trialFRMD5
Miscellaneous
canSAR (ICR)FRMD5 (select the gene name)
DataMed IndexFRMD5
Probes
Litterature
PubMed17 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFRMD5
EVEXFRMD5
GoPubMedFRMD5
iHOPFRMD5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Jan 17 18:13:21 CET 2019

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