GPR37 (G protein-coupled receptor 37)

1. Identity

Alias_names
General Information
Alias_symbol (synonym)EDNRBL
hET(B)R-LP
PAELR
Other alias
HGNC (Hugo) GPR37
LocusID (NCBI) 2861
Atlas_Id 55392
Location 7q31.33  [Link to chromosome band 7q31]
Location_base_pair Starts at 124743885 and ends at 124766108 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

2. DNA/RNA

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

 

3. External links

Nomenclature
HGNC (Hugo)GPR37   4494
Cards
Entrez_Gene (NCBI)GPR37  2861  G protein-coupled receptor 37
AliasesEDNRBL; PAELR; hET(B)R-LP
GeneCards (Weizmann)GPR37
Ensembl hg19 (Hinxton)ENSG00000170775 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000170775 [Gene_View] &nbspENSG00000170775 [Sequence]  chr7:124743885-124766108 [Contig_View]  GPR37 [Vega]
ICGC DataPortalENSG00000170775
TCGA cBioPortalGPR37
AceView (NCBI)GPR37
Genatlas (Paris)GPR37
WikiGenes2861
SOURCE (Princeton)GPR37
Genetics Home Reference (NIH)GPR37
Genomic and cartography
GoldenPath hg38 (UCSC)GPR37  -     chr7:124743885-124766108 -  7q31.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GPR37  -     7q31.33   [Description]    (hg19-Feb_2009)
EnsemblGPR37 - 7q31.33 [CytoView hg19]  GPR37 - 7q31.33 [CytoView hg38]
Mapping of homologs : NCBIGPR37 [Mapview hg19]  GPR37 [Mapview hg38]
OMIM602583   
Gene and transcription
Genbank (Entrez)AF017262 AF502281 BC040007 DB475687 DB495592
RefSeq transcript (Entrez)NM_005302
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GPR37
Cluster EST : UnigeneHs.731392 [ NCBI ]
CGAP (NCI)Hs.731392
Alternative Splicing GalleryENSG00000170775
Gene ExpressionGPR37 [ NCBI-GEO ]   GPR37 [ EBI - ARRAY_EXPRESS ]   GPR37 [ SEEK ]   GPR37 [ MEM ]
Gene Expression Viewer (FireBrowse)GPR37 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets] &nbsp [Normal Tissue Atlas] &nbsp[carcinoma Classsification] &nbsp[NCI60]
GenevestigatorExpression in : [tissues] &nbsp[cell-lines] &nbsp[cancer] &nbsp[perturbations] &nbsp
BioGPS (Tissue expression)2861
GTEX Portal (Tissue expression)GPR37
Human Protein AtlasENSG00000170775-GPR37 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO15354   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO15354  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO15354
Splice isoforms : SwissVarO15354
PhosPhoSitePlusO15354
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)GPCR_Rhodpsn    GPCR_Rhodpsn_7TM    GPR37_orph   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Conserved Domain (NCBI)GPR37
DMDM Disease mutations2861
Blocks (Seattle)GPR37
SuperfamilyO15354
Human Protein Atlas [tissue]ENSG00000170775-GPR37 [tissue]
Peptide AtlasO15354
HPRD03992
IPIIPI00006166   
Protein Interaction databases
DIP (DOE-UCLA)O15354
IntAct (EBI)O15354
FunCoupENSG00000170775
BioGRIDGPR37
STRING (EMBL)GPR37
ZODIACGPR37
Ontologies - Pathways
QuickGOO15354
Ontology : AmiGOubiquitin ligase complex  G protein-coupled receptor activity  protein binding  endoplasmic reticulum  endoplasmic reticulum membrane  plasma membrane  plasma membrane  integral component of plasma membrane  G protein-coupled receptor signaling pathway  adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  G protein-coupled peptide receptor activity  Hsp70 protein binding  heat shock protein binding  ubiquitin protein ligase binding  locomotion involved in locomotory behavior  prosaposin receptor activity  peptide binding  dopamine biosynthetic process  receptor complex  positive regulation of MAPK cascade  positive regulation of dopamine metabolic process  negative regulation of hydrogen peroxide-induced cell death  
Ontology : EGO-EBIubiquitin ligase complex  G protein-coupled receptor activity  protein binding  endoplasmic reticulum  endoplasmic reticulum membrane  plasma membrane  plasma membrane  integral component of plasma membrane  G protein-coupled receptor signaling pathway  adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  G protein-coupled peptide receptor activity  Hsp70 protein binding  heat shock protein binding  ubiquitin protein ligase binding  locomotion involved in locomotory behavior  prosaposin receptor activity  peptide binding  dopamine biosynthetic process  receptor complex  positive regulation of MAPK cascade  positive regulation of dopamine metabolic process  negative regulation of hydrogen peroxide-induced cell death  
Pathways : KEGGParkinson's disease   
NDEx NetworkGPR37
Atlas of Cancer Signalling NetworkGPR37
Wikipedia pathwaysGPR37
Orthology - Evolution
OrthoDB2861
GeneTree (enSembl)ENSG00000170775
Phylogenetic Trees/Animal Genes : TreeFamGPR37
HOGENOMO15354
Homologs : HomoloGeneGPR37
Homology/Alignments : Family Browser (UCSC)GPR37
Gene fusions - Rearrangements
Fusion : QuiverGPR37
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGPR37 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GPR37
dbVarGPR37
ClinVarGPR37
1000_GenomesGPR37 
Exome Variant ServerGPR37
ExAC (Exome Aggregation Consortium)ENSG00000170775
GNOMAD BrowserENSG00000170775
Varsome BrowserGPR37
Genetic variants : HAPMAP2861
Genomic Variants (DGV)GPR37 [DGVbeta]
DECIPHERGPR37 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGPR37 
Mutations
ICGC Data PortalGPR37 
TCGA Data PortalGPR37 
Broad Tumor PortalGPR37
OASIS PortalGPR37 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGPR37  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGPR37
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GPR37
DgiDB (Drug Gene Interaction Database)GPR37
DoCM (Curated mutations)GPR37 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GPR37 (select a term)
intoGenGPR37
Cancer3DGPR37(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602583   
Orphanet
DisGeNETGPR37
MedgenGPR37
Genetic Testing Registry GPR37
NextProtO15354 [Medical]
TSGene2861
GENETestsGPR37
Target ValidationGPR37
Huge Navigator GPR37 [HugePedia]
snp3D : Map Gene to Disease2861
BioCentury BCIQGPR37
ClinGenGPR37
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2861
Chemical/Pharm GKB GenePA28882
Clinical trialGPR37
Miscellaneous
canSAR (ICR)GPR37 (select the gene name)
DataMed IndexGPR37
Probes
Litterature
PubMed36 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGPR37
EVEXGPR37
GoPubMedGPR37
iHOPGPR37
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jan 17 18:14:57 CET 2019

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