GRB7 (growth factor receptor bound protein 7)

1. Identity

Alias_names
General Information
Other alias-
HGNC (Hugo) GRB7
LocusID (NCBI) 2886
Atlas_Id 40750
Location 17q12  [Link to chromosome band 17q12]
Location_base_pair Starts at 39737909 and ends at 39747285 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GRB7 (17q12) / PGAP3 (17q12)GRB7 (17q12) / PLXDC1 (17q12)GRB7 17q12 / PGAP3 17q12
GRB7 17q12 / PLXDC1 17q12

2. DNA/RNA

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

 

3. External links

Nomenclature
HGNC (Hugo)GRB7   4567
Cards
Entrez_Gene (NCBI)GRB7  2886  growth factor receptor bound protein 7
Aliases
GeneCards (Weizmann)GRB7
Ensembl hg19 (Hinxton)ENSG00000141738 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000141738 [Gene_View] &nbspENSG00000141738 [Sequence]  chr17:39737909-39747285 [Contig_View]  GRB7 [Vega]
ICGC DataPortalENSG00000141738
TCGA cBioPortalGRB7
AceView (NCBI)GRB7
Genatlas (Paris)GRB7
WikiGenes2886
SOURCE (Princeton)GRB7
Genetics Home Reference (NIH)GRB7
Genomic and cartography
GoldenPath hg38 (UCSC)GRB7  -     chr17:39737909-39747285 +  17q12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GRB7  -     17q12   [Description]    (hg19-Feb_2009)
EnsemblGRB7 - 17q12 [CytoView hg19]  GRB7 - 17q12 [CytoView hg38]
Mapping of homologs : NCBIGRB7 [Mapview hg19]  GRB7 [Mapview hg38]
OMIM601522   
Gene and transcription
Genbank (Entrez)AB008789 AB008790 AK027729 AK125544 AK222849
RefSeq transcript (Entrez)NM_001030002 NM_001242442 NM_001242443 NM_001330207 NM_005310
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GRB7
Cluster EST : UnigeneHs.86859 [ NCBI ]
CGAP (NCI)Hs.86859
Alternative Splicing GalleryENSG00000141738
Gene ExpressionGRB7 [ NCBI-GEO ]   GRB7 [ EBI - ARRAY_EXPRESS ]   GRB7 [ SEEK ]   GRB7 [ MEM ]
Gene Expression Viewer (FireBrowse)GRB7 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets] &nbsp [Normal Tissue Atlas] &nbsp[carcinoma Classsification] &nbsp[NCI60]
GenevestigatorExpression in : [tissues] &nbsp[cell-lines] &nbsp[cancer] &nbsp[perturbations] &nbsp
BioGPS (Tissue expression)2886
GTEX Portal (Tissue expression)GRB7
Human Protein AtlasENSG00000141738-GRB7 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14451   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14451  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14451
Splice isoforms : SwissVarQ14451
PhosPhoSitePlusQ14451
Domaine pattern : Prosite (Expaxy)PH_DOMAIN (PS50003)    RA (PS50200)    SH2 (PS50001)   
Domains : Interpro (EBI)BPS-dom    Grb7    PH-like_dom_sf    PH_domain    RA_dom    SH2    SH2_dom_sf    Ubiquitin-like_domsf   
Domain families : Pfam (Sanger)BPS (PF08947)    PH (PF00169)    RA (PF00788)    SH2 (PF00017)   
Domain families : Pfam (NCBI)pfam08947    pfam00169    pfam00788    pfam00017   
Domain families : Smart (EMBL)PH (SM00233)  RA (SM00314)  SH2 (SM00252)  
Conserved Domain (NCBI)GRB7
DMDM Disease mutations2886
Blocks (Seattle)GRB7
PDB (RSDB)1MW4    1WGR    2L4K    2QMS    3PQZ    4WWQ    4X6S    5D0J    5EEL    5EEQ    5TYI    5U06    5U1Q   
PDB Europe1MW4    1WGR    2L4K    2QMS    3PQZ    4WWQ    4X6S    5D0J    5EEL    5EEQ    5TYI    5U06    5U1Q   
PDB (PDBSum)1MW4    1WGR    2L4K    2QMS    3PQZ    4WWQ    4X6S    5D0J    5EEL    5EEQ    5TYI    5U06    5U1Q   
PDB (IMB)1MW4    1WGR    2L4K    2QMS    3PQZ    4WWQ    4X6S    5D0J    5EEL    5EEQ    5TYI    5U06    5U1Q   
Structural Biology KnowledgeBase1MW4    1WGR    2L4K    2QMS    3PQZ    4WWQ    4X6S    5D0J    5EEL    5EEQ    5TYI    5U06    5U1Q   
SCOP (Structural Classification of Proteins)1MW4    1WGR    2L4K    2QMS    3PQZ    4WWQ    4X6S    5D0J    5EEL    5EEQ    5TYI    5U06    5U1Q   
CATH (Classification of proteins structures)1MW4    1WGR    2L4K    2QMS    3PQZ    4WWQ    4X6S    5D0J    5EEL    5EEQ    5TYI    5U06    5U1Q   
SuperfamilyQ14451
Human Protein Atlas [tissue]ENSG00000141738-GRB7 [tissue]
Peptide AtlasQ14451
HPRD03311
IPIIPI00939546   IPI00293948   IPI00448767   IPI00902705   
Protein Interaction databases
DIP (DOE-UCLA)Q14451
IntAct (EBI)Q14451
FunCoupENSG00000141738
BioGRIDGRB7
STRING (EMBL)GRB7
ZODIACGRB7
Ontologies - Pathways
QuickGOQ14451
Ontology : AmiGORNA binding  SH3/SH2 adaptor activity  protein binding  cytosol  cytosol  plasma membrane  focal adhesion  epidermal growth factor receptor signaling pathway  axon guidance  positive regulation of signal transduction  cytoplasmic stress granule  negative regulation of translation  protein kinase binding  positive regulation of cell migration  stress granule assembly  phosphatidylinositol binding  ERBB2 signaling pathway  identical protein binding  cell projection  leukocyte migration  
Ontology : EGO-EBIRNA binding  SH3/SH2 adaptor activity  protein binding  cytosol  cytosol  plasma membrane  focal adhesion  epidermal growth factor receptor signaling pathway  axon guidance  positive regulation of signal transduction  cytoplasmic stress granule  negative regulation of translation  protein kinase binding  positive regulation of cell migration  stress granule assembly  phosphatidylinositol binding  ERBB2 signaling pathway  identical protein binding  cell projection  leukocyte migration  
NDEx NetworkGRB7
Atlas of Cancer Signalling NetworkGRB7
Wikipedia pathwaysGRB7
Orthology - Evolution
OrthoDB2886
GeneTree (enSembl)ENSG00000141738
Phylogenetic Trees/Animal Genes : TreeFamGRB7
HOGENOMQ14451
Homologs : HomoloGeneGRB7
Homology/Alignments : Family Browser (UCSC)GRB7
Gene fusions - Rearrangements
Fusion PortalGRB7 17q12 PGAP3 17q12 BRCA
Fusion PortalGRB7 17q12 PLXDC1 17q12 BLCA
Fusion : QuiverGRB7
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGRB7 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GRB7
dbVarGRB7
ClinVarGRB7
1000_GenomesGRB7 
Exome Variant ServerGRB7
ExAC (Exome Aggregation Consortium)ENSG00000141738
GNOMAD BrowserENSG00000141738
Varsome BrowserGRB7
Genetic variants : HAPMAP2886
Genomic Variants (DGV)GRB7 [DGVbeta]
DECIPHERGRB7 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGRB7 
Mutations
ICGC Data PortalGRB7 
TCGA Data PortalGRB7 
Broad Tumor PortalGRB7
OASIS PortalGRB7 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGRB7  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGRB7
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GRB7
DgiDB (Drug Gene Interaction Database)GRB7
DoCM (Curated mutations)GRB7 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GRB7 (select a term)
intoGenGRB7
Cancer3DGRB7(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601522   
Orphanet
DisGeNETGRB7
MedgenGRB7
Genetic Testing Registry GRB7
NextProtQ14451 [Medical]
TSGene2886
GENETestsGRB7
Target ValidationGRB7
Huge Navigator GRB7 [HugePedia]
snp3D : Map Gene to Disease2886
BioCentury BCIQGRB7
ClinGenGRB7
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2886
Chemical/Pharm GKB GenePA28963
Clinical trialGRB7
Miscellaneous
canSAR (ICR)GRB7 (select the gene name)
DataMed IndexGRB7
Probes
Litterature
PubMed81 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGRB7
EVEXGRB7
GoPubMedGRB7
iHOPGRB7
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Jan 17 18:15:04 CET 2019

For comments and suggestions or contributions, please contact us atlasgeneticsoncology@usal.es.