IGL (Immunoglobulin Lambda)

1. Identity

Alias_names	General Information
Other alias	IGL@ (Immunoglobulin Lambda)
HGNC (Hugo)	IGL
LocusID (NCBI)	3535
Atlas_Id	54
Location	22q11.22  [Link to chromosome band 22q11]
Location_base_pair	Starts at 21919419 and ends at 23180048 bp from pter
	for complete Figure, see: chromosome 22, IMGT (The International ImMunoGeneTics information system ®) © Copyright 1995-2017 IMGT, IMGT is a CNRS trademark

Fusion genes (updated 2017)

Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

The human IGL locus is located on chromosome 22 on the long arm, at band 22q11.2 The orientation of the locus has been determined by the analysis of translocations, involving the IGL locus, in leukemia and lymphoma. Sequencing of the long arm of chromosome 22 showed that it encompasses about 35 megabases of DNA and that the IGL locus is localized at 6 megabases from the centromere. Although the correlation between DNA sequences and chromosomal bands has not yet been made, the localization of the IGL locus can be refined to 22q11.2

2. DNA/RNA

	IGL V-GENE: Green box: Functional; Yellow box: Open reading frame; Red: Pseudogene. J-GENE: Grey: Functional . C-GENE: Blue: Functional; Blue open box: Pseudogene; Blue triangle: Not sequenced. GENES NOT RELATED: Purple open box: Pseudogene. for complete Figure, see: locus IGL, IMGT (The International ImMunoGeneTics information system ®) © Copyright 1995-2017 IMGT, IMGT is a CNRS trademark
Description	The human IGL locus at 22q11.2 spans 1050 kb. It consists of 70 to 71 IGLV genes, localized on 900 kb, 7 to 11 IGLJ and 7 to 11 IGLC genes depending on the haplotypes, each IGLC gene being preceded by one IGLJ segment. Fifty-six to 57 genes belong to 11 subgroups, whereas 14 pseudogenes which are too divergent to be assigned to subgroups, have been assigned to 3 clans. The most 5' IGLV genes occupy the more centromeric position, whereas the IGLC genes, in 3' of the locus, are the most telomeric genes in the IGL locus. The potential genomic IGL repertoire comprises 29 to 32 functional IGLV genes belonging to 10 subgroups, 4 to 5 IGLJ, and 4 to 5 IGLC functional genes in the 7-IGLC gene haplotype. One, 2, 3 or 4 additional IGLC genes, each one probably preceded by one IGLJ, have been shown to characterize IGLC haplotypes with 8, 9, 10 or 11 genes, but these genes have not yet been sequenced. Two IGLV orphons have been identified on chromosome 8 at 8q11.2 and one of them belonging to subgroup 8 has been sequenced. The recent sequencing of the chromosome 22q showed that the IGL locus is localized at 6 megabases from the centromere. Two IGLC orphons and two IGLV orphons have also been characterized on 22q outside of the major IGL locus (See also IMGT Repertoire) The total number of human IGL genes per haploid genome is 84-93 (90-99 genes, if the orphons are included) of which 37-42 genes are functional List of the human IGL genes

3. Protein

4. Mutations

5. Implicated in

Note
Entity	Translocations which frequently result from errors of the recombinase enzyme complexe (RAG1, RAG2, etc.), responsable of the Immunoglobulin and T cell receptor V-J and V-D-J rearrangements. IGLV or IGLJ recombination signals or isolated heptamer are observed at the breakpoints.
	c-Immunoglobulin gene IgL at 22q11, in normal cells: PAC 1019H10 and PAC 869I1 - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics.
Entity	t(3;22)(q27;q11); involve IGL - BCL6 in 3q27
Disease	B-cell non-Hodgkin lymphomas (NHL), mainly diffuse large cell lymphoma; adult aggressive lymphoma
Prognosis	controversial
Entity	t(8;22)(q24;q11); involve IGL - C-MYC in 8q24
Disease	B-cell acute lymphoblastic leukemia (ALL3) and non-Hodgkin lymphomas (NHL), especially in the Burkitt lymphoma
Prognosis	the prognosis has evolved with new treatments

6. Breakpoints

7. Bibliography

8. Citation

9. Other Leukemias implicated (Data extracted from papers in the Atlas) [ 15 ]

10. External links