IGL (Immunoglobulin Lambda)
Written | 2000-07 | Marie-Paule Lefranc |
IMGT, LIGM, IGH, UPR CNRS 1142, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France |
(Note : for Links provided by Atlas : click)
1. Identity
Alias_names | General Information |
Other alias | IGL@ (Immunoglobulin Lambda) |
HGNC (Hugo) | IGL |
LocusID (NCBI) | 3535 |
Atlas_Id | 54 |
Location | 22q11.22 [Link to chromosome band 22q11] |
Location_base_pair | Starts at 21919419 and ends at 23180048 bp from pter |
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for complete Figure, see: chromosome 22, IMGT (The International ImMunoGeneTics information system ®) © Copyright 1995-2017 IMGT, IMGT is a CNRS trademark | |
Fusion genes (updated 2017) | Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands) |
Note | The human IGL locus is located on chromosome 22 on the long arm, at band 22q11.2 The orientation of the locus has been determined by the analysis of translocations, involving the IGL locus, in leukemia and lymphoma. Sequencing of the long arm of chromosome 22 showed that it encompasses about 35 megabases of DNA and that the IGL locus is localized at 6 megabases from the centromere. Although the correlation between DNA sequences and chromosomal bands has not yet been made, the localization of the IGL locus can be refined to 22q11.2 |
2. DNA/RNA
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IGL V-GENE: Green box: Functional; Yellow box: Open reading frame; Red: Pseudogene. J-GENE: Grey: Functional . C-GENE: Blue: Functional; Blue open box: Pseudogene; Blue triangle: Not sequenced. GENES NOT RELATED: Purple open box: Pseudogene. for complete Figure, see: locus IGL, IMGT (The International ImMunoGeneTics information system ®) © Copyright 1995-2017 IMGT, IMGT is a CNRS trademark | |
Description | |
3. Protein
Description | |
4. Mutations
Note | Mutations which correspond to allelic polymorphisms of the functional germline IGLV, IGLJ and IGLC genes are described in the IMGT database: (IMGT Repertoire>Alignments of alleles) |
5. Implicated in
Note | |
Entity | Translocations which frequently result from errors of the recombinase enzyme complexe (RAG1, RAG2, etc.), responsable of the Immunoglobulin and T cell receptor V-J and V-D-J rearrangements. IGLV or IGLJ recombination signals or isolated heptamer are observed at the breakpoints. |
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c-Immunoglobulin gene IgL at 22q11, in normal cells: PAC 1019H10 and PAC 869I1 - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics. | |
Entity | t(3;22)(q27;q11); involve IGL - BCL6 in 3q27 |
Disease | B-cell non-Hodgkin lymphomas (NHL), mainly diffuse large cell lymphoma; adult aggressive lymphoma |
Prognosis | controversial |
Entity | t(8;22)(q24;q11); involve IGL - C-MYC in 8q24 |
Disease | B-cell acute lymphoblastic leukemia (ALL3) and non-Hodgkin lymphomas (NHL), especially in the Burkitt lymphoma |
Prognosis | the prognosis has evolved with new treatments |
6. Breakpoints
7. Bibliography
Human immunoglobulin C lambda 6 gene encodes the Kern+Oz-lambda chain and C lambda 4 and C lambda 5 are pseudogenes. |
Dariavach P, Lefranc G, Lefranc MP |
Proceedings of the National Academy of Sciences of the United States of America. 1987 ; 84 (24) : 9074-9078. |
PMID 3122211 |
Chromosomal orientation of the lambda light chain locus: V lambda is proximal to C lambda in 22q11. |
Emanuel BS, Cannizzaro LA, Magrath I, Tsujimoto Y, Nowell PC, Croce CM |
Nucleic acids research. 1985 ; 13 (2) : 381-387. |
PMID 3923432 |
Organization of the human immunoglobulin lambda light-chain locus on chromosome 22q11.2. |
Frippiat JP, Williams SC, Tomlinson IM, Cook GP, Cherif D, Le Paslier D, Collins JE, Dunham I, Winter G, Lefranc MP |
Human molecular genetics. 1995 ; 4 (6) : 983-991. |
PMID 7655473 |
Polymorphism of immunoglobulin lambda constant region genes in populations from France, Lebanon and Tunisia. |
Ghanem N, Dariavach P, Bensmana M, Chibani J, Lefranc G, Lefranc MP |
Experimental and clinical immunogenetics. 1988 ; 5 (4) : 186-195. |
PMID 2908491 |
One-megabase sequence analysis of the human immunoglobulin lambda gene locus. |
Kawasaki K, Minoshima S, Nakato E, Shibuya K, Shintani A, Schmeits JL, Wang J, Shimizu N |
Genome research. 1997 ; 7 (3) : 250-261. |
PMID 9074928 |
Nomenclature of the human immunoglobulin lambda (IGL) genes. |
Lefranc MP |
Experimental and clinical immunogenetics. 2001 ; 18 (4) : 242-254. |
PMID 11872955 |
The Immunoglobulin FactsBook (Review) |
Lefranc MP and Lefranc G |
Academic Press, London, UK (458 pages), 2001. ISBN: 012441351X |
Allelic polymorphisms and RFLP in the human immunoglobulin lambda light chain locus. |
Lefranc MP, Pallarè N, Frippiat JP |
Human genetics. 1999 ; 104 (5) : 361-369. |
PMID 10394926 |
Protein displays of the human immunoglobulin heavy, kappa and lambda variable and joining regions. |
Scaviner D, Barbié V, Ruiz M, Lefranc MP |
Experimental and clinical immunogenetics. 1999 ; 16 (4) : 234-240. |
PMID 10575277 |
Structure and expression of the human immunoglobulin lambda genes. |
Vasicek TJ, Leder P |
The Journal of experimental medicine. 1990 ; 172 (2) : 609-620. |
PMID 2115572 |
8. Citation
This paper should be referenced as such : |
Lefranc, MP |
IGL (immunoglobulin lambda) |
Atlas Genet Cytogenet Oncol Haematol. 2000;4(3):114-116. |
Free journal version : [ pdf ] [ DOI ] |
On line version : http://atlasgeneticsoncology.usal.es/classic/Genes/IgLID54.html |
9. Other Leukemias implicated (Data extracted from papers in the Atlas) [ 15 ]
Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ] |
t(8;22)(q24;q11) IGL/MYC
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10. External links
REVIEW articles | automatic search in PubMed |
Last year publications | automatic search in PubMed |
© Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Thu Jan 17 18:58:00 CET 2019 |
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