IL12A (interleukin 12A)

1. Identity

Alias_names
General Information
interleukin 12A (natural killer cell stimulatory factor 1
Alias_symbol (synonym)CLMF
IL-12A
p35
NFSK
Other aliasP35
HGNC (Hugo) IL12A
LocusID (NCBI) 3592
Atlas_Id 40940
Location 3q25.33  [Link to chromosome band 3q25]
Location_base_pair Starts at 159988836 and ends at 159996019 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

2. DNA/RNA

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

 

3. External links

Nomenclature
HGNC (Hugo)IL12A   5969
Cards
Entrez_Gene (NCBI)IL12A  3592  interleukin 12A
AliasesCLMF; IL-12A; NFSK; NKSF1; 
P35
GeneCards (Weizmann)IL12A
Ensembl hg19 (Hinxton)ENSG00000168811 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000168811 [Gene_View] &nbspENSG00000168811 [Sequence]  chr3:159988836-159996019 [Contig_View]  IL12A [Vega]
ICGC DataPortalENSG00000168811
TCGA cBioPortalIL12A
AceView (NCBI)IL12A
Genatlas (Paris)IL12A
WikiGenes3592
SOURCE (Princeton)IL12A
Genetics Home Reference (NIH)IL12A
Genomic and cartography
GoldenPath hg38 (UCSC)IL12A  -     chr3:159988836-159996019 +  3q25.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IL12A  -     3q25.33   [Description]    (hg19-Feb_2009)
EnsemblIL12A - 3q25.33 [CytoView hg19]  IL12A - 3q25.33 [CytoView hg38]
Mapping of homologs : NCBIIL12A [Mapview hg19]  IL12A [Mapview hg38]
OMIM161560   
Gene and transcription
Genbank (Entrez)AF101062 AF180562 AW472810 BC035571 BC104982
RefSeq transcript (Entrez)NM_000882 NM_001354582 NM_001354583
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)IL12A
Cluster EST : UnigeneHs.673 [ NCBI ]
CGAP (NCI)Hs.673
Alternative Splicing GalleryENSG00000168811
Gene ExpressionIL12A [ NCBI-GEO ]   IL12A [ EBI - ARRAY_EXPRESS ]   IL12A [ SEEK ]   IL12A [ MEM ]
Gene Expression Viewer (FireBrowse)IL12A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets] &nbsp [Normal Tissue Atlas] &nbsp[carcinoma Classsification] &nbsp[NCI60]
GenevestigatorExpression in : [tissues] &nbsp[cell-lines] &nbsp[cancer] &nbsp[perturbations] &nbsp
BioGPS (Tissue expression)3592
GTEX Portal (Tissue expression)IL12A
Human Protein AtlasENSG00000168811-IL12A [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP29459   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP29459  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP29459
Splice isoforms : SwissVarP29459
PhosPhoSitePlusP29459
Domains : Interpro (EBI)4_helix_cytokine-like_core    IL-12_alpha   
Domain families : Pfam (Sanger)IL12 (PF03039)   
Domain families : Pfam (NCBI)pfam03039   
Conserved Domain (NCBI)IL12A
DMDM Disease mutations3592
Blocks (Seattle)IL12A
PDB (RSDB)1F45    3HMX   
PDB Europe1F45    3HMX   
PDB (PDBSum)1F45    3HMX   
PDB (IMB)1F45    3HMX   
Structural Biology KnowledgeBase1F45    3HMX   
SCOP (Structural Classification of Proteins)1F45    3HMX   
CATH (Classification of proteins structures)1F45    3HMX   
SuperfamilyP29459
Human Protein Atlas [tissue]ENSG00000168811-IL12A [tissue]
Peptide AtlasP29459
HPRD01193
IPIIPI00182737   IPI00945108   IPI00796173   
Protein Interaction databases
DIP (DOE-UCLA)P29459
IntAct (EBI)P29459
FunCoupENSG00000168811
BioGRIDIL12A
STRING (EMBL)IL12A
ZODIACIL12A
Ontologies - Pathways
QuickGOP29459
Ontology : AmiGOpositive regulation of T cell mediated cytotoxicity  positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target  cytokine activity  cytokine activity  interleukin-12 receptor binding  protein binding  extracellular region  extracellular space  endoplasmic reticulum lumen  immune response  cell cycle arrest  growth factor activity  growth factor activity  cell proliferation  response to virus  cell surface  response to UV-B  regulation of signaling receptor activity  cell migration  cytokine-mediated signaling pathway  late endosome lumen  response to lipopolysaccharide  interferon-gamma production  negative regulation of interleukin-17 production  positive regulation of interferon-gamma production  positive regulation of natural killer cell activation  positive regulation of mononuclear cell proliferation  positive regulation of smooth muscle cell apoptotic process  T-helper 1 cell activation  interleukin-12-mediated signaling pathway  T-helper 1 cell cytokine production  positive regulation of T cell proliferation  interleukin-12 beta subunit binding  positive regulation of tyrosine phosphorylation of STAT protein  defense response to protozoan  interleukin-12 complex  interleukin-12 complex  interleukin-27 binding  positive regulation of T cell differentiation  positive regulation of cell adhesion  positive regulation of natural killer cell mediated cytotoxicity  protein heterodimerization activity  negative regulation of smooth muscle cell proliferation  positive regulation of lymphocyte proliferation  defense response to Gram-positive bacterium  positive regulation of NK T cell activation  interleukin-35-mediated signaling pathway  cellular response to lipopolysaccharide  extrinsic apoptotic signaling pathway  cellular response to virus  positive regulation of dendritic cell chemotaxis  
Ontology : EGO-EBIpositive regulation of T cell mediated cytotoxicity  positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target  cytokine activity  cytokine activity  interleukin-12 receptor binding  protein binding  extracellular region  extracellular space  endoplasmic reticulum lumen  immune response  cell cycle arrest  growth factor activity  growth factor activity  cell proliferation  response to virus  cell surface  response to UV-B  regulation of signaling receptor activity  cell migration  cytokine-mediated signaling pathway  late endosome lumen  response to lipopolysaccharide  interferon-gamma production  negative regulation of interleukin-17 production  positive regulation of interferon-gamma production  positive regulation of natural killer cell activation  positive regulation of mononuclear cell proliferation  positive regulation of smooth muscle cell apoptotic process  T-helper 1 cell activation  interleukin-12-mediated signaling pathway  T-helper 1 cell cytokine production  positive regulation of T cell proliferation  interleukin-12 beta subunit binding  positive regulation of tyrosine phosphorylation of STAT protein  defense response to protozoan  interleukin-12 complex  interleukin-12 complex  interleukin-27 binding  positive regulation of T cell differentiation  positive regulation of cell adhesion  positive regulation of natural killer cell mediated cytotoxicity  protein heterodimerization activity  negative regulation of smooth muscle cell proliferation  positive regulation of lymphocyte proliferation  defense response to Gram-positive bacterium  positive regulation of NK T cell activation  interleukin-35-mediated signaling pathway  cellular response to lipopolysaccharide  extrinsic apoptotic signaling pathway  cellular response to virus  positive regulation of dendritic cell chemotaxis  
Pathways : KEGGCytokine-cytokine receptor interaction    Toll-like receptor signaling pathway    RIG-I-like receptor signaling pathway    Jak-STAT signaling pathway    Type I diabetes mellitus    Pertussis    Legionellosis    Leishmaniasis    Chagas disease (American trypanosomiasis)    African trypanosomiasis    Malaria    Toxoplasmosis    Amoebiasis    Tuberculosis    Measles    Influenza A    Herpes simplex infection    Inflammatory bowel disease (IBD)    Allograft rejection   
NDEx NetworkIL12A
Atlas of Cancer Signalling NetworkIL12A
Wikipedia pathwaysIL12A
Orthology - Evolution
OrthoDB3592
GeneTree (enSembl)ENSG00000168811
Phylogenetic Trees/Animal Genes : TreeFamIL12A
HOGENOMP29459
Homologs : HomoloGeneIL12A
Homology/Alignments : Family Browser (UCSC)IL12A
Gene fusions - Rearrangements
Fusion : QuiverIL12A
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIL12A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IL12A
dbVarIL12A
ClinVarIL12A
1000_GenomesIL12A 
Exome Variant ServerIL12A
ExAC (Exome Aggregation Consortium)ENSG00000168811
GNOMAD BrowserENSG00000168811
Varsome BrowserIL12A
Genetic variants : HAPMAP3592
Genomic Variants (DGV)IL12A [DGVbeta]
DECIPHERIL12A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIL12A 
Mutations
ICGC Data PortalIL12A 
TCGA Data PortalIL12A 
Broad Tumor PortalIL12A
OASIS PortalIL12A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIL12A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDIL12A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch IL12A
DgiDB (Drug Gene Interaction Database)IL12A
DoCM (Curated mutations)IL12A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IL12A (select a term)
intoGenIL12A
Cancer3DIL12A(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM161560   
Orphanet703    874   
DisGeNETIL12A
MedgenIL12A
Genetic Testing Registry IL12A
NextProtP29459 [Medical]
TSGene3592
GENETestsIL12A
Target ValidationIL12A
Huge Navigator IL12A [HugePedia]
snp3D : Map Gene to Disease3592
BioCentury BCIQIL12A
ClinGenIL12A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3592
Chemical/Pharm GKB GenePA29784
Clinical trialIL12A
Miscellaneous
canSAR (ICR)IL12A (select the gene name)
DataMed IndexIL12A
Probes
Litterature
PubMed384 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIL12A
EVEXIL12A
GoPubMedIL12A
iHOPIL12A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jan 17 18:17:43 CET 2019

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