IL4 (interleukin 4)

1. Identity

Alias_symbol (synonym)
General Information
IL-4
BCGF1
BCGF-1
MGC79402
Other aliasBSF-1
HGNC (Hugo) IL4
LocusID (NCBI) 3565
Atlas_Id 40960
Location 5q31.1  [Link to chromosome band 5q31]
Location_base_pair Starts at 132673986 and ends at 132682678 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

2. DNA/RNA

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

 

3. External links

Nomenclature
HGNC (Hugo)IL4   6014
Cards
Entrez_Gene (NCBI)IL4  3565  interleukin 4
AliasesBCGF-1; BCGF1; BSF-1; BSF1; 
IL-4
GeneCards (Weizmann)IL4
Ensembl hg19 (Hinxton)ENSG00000113520 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000113520 [Gene_View] &nbspENSG00000113520 [Sequence]  chr5:132673986-132682678 [Contig_View]  IL4 [Vega]
ICGC DataPortalENSG00000113520
TCGA cBioPortalIL4
AceView (NCBI)IL4
Genatlas (Paris)IL4
WikiGenes3565
SOURCE (Princeton)IL4
Genetics Home Reference (NIH)IL4
Genomic and cartography
GoldenPath hg38 (UCSC)IL4  -     chr5:132673986-132682678 +  5q31.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)IL4  -     5q31.1   [Description]    (hg19-Feb_2009)
EnsemblIL4 - 5q31.1 [CytoView hg19]  IL4 - 5q31.1 [CytoView hg38]
Mapping of homologs : NCBIIL4 [Mapview hg19]  IL4 [Mapview hg38]
OMIM147780   
Gene and transcription
Genbank (Entrez)AB102862 AF043336 AM937235 BC066277 BC066278
RefSeq transcript (Entrez)NM_000589 NM_001354990 NM_172348
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)IL4
Cluster EST : UnigeneHs.73917 [ NCBI ]
CGAP (NCI)Hs.73917
Alternative Splicing GalleryENSG00000113520
Gene ExpressionIL4 [ NCBI-GEO ]   IL4 [ EBI - ARRAY_EXPRESS ]   IL4 [ SEEK ]   IL4 [ MEM ]
Gene Expression Viewer (FireBrowse)IL4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets] &nbsp [Normal Tissue Atlas] &nbsp[carcinoma Classsification] &nbsp[NCI60]
GenevestigatorExpression in : [tissues] &nbsp[cell-lines] &nbsp[cancer] &nbsp[perturbations] &nbsp
BioGPS (Tissue expression)3565
GTEX Portal (Tissue expression)IL4
Human Protein AtlasENSG00000113520-IL4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP05112   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP05112  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP05112
Splice isoforms : SwissVarP05112
PhosPhoSitePlusP05112
Domaine pattern : Prosite (Expaxy)INTERLEUKIN_4_13 (PS00838)   
Domains : Interpro (EBI)4_helix_cytokine-like_core    IL-4    IL-4/IL-13    IL-4/IL-13_CS   
Domain families : Pfam (Sanger)IL4 (PF00727)   
Domain families : Pfam (NCBI)pfam00727   
Domain families : Smart (EMBL)IL4_13 (SM00190)  
Conserved Domain (NCBI)IL4
DMDM Disease mutations3565
Blocks (Seattle)IL4
PDB (RSDB)1BBN    1BCN    1CYL    1HIJ    1HIK    1HZI    1IAR    1ILL    1ITE    1ITI    1ITL    1ITM    1RCB    2B8U    2B8X    2B8Y    2B8Z    2B90    2B91    2CYK    2D48    2INT    3BPL    3BPN    3QB7    4YDY    5FHX   
PDB Europe1BBN    1BCN    1CYL    1HIJ    1HIK    1HZI    1IAR    1ILL    1ITE    1ITI    1ITL    1ITM    1RCB    2B8U    2B8X    2B8Y    2B8Z    2B90    2B91    2CYK    2D48    2INT    3BPL    3BPN    3QB7    4YDY    5FHX   
PDB (PDBSum)1BBN    1BCN    1CYL    1HIJ    1HIK    1HZI    1IAR    1ILL    1ITE    1ITI    1ITL    1ITM    1RCB    2B8U    2B8X    2B8Y    2B8Z    2B90    2B91    2CYK    2D48    2INT    3BPL    3BPN    3QB7    4YDY    5FHX   
PDB (IMB)1BBN    1BCN    1CYL    1HIJ    1HIK    1HZI    1IAR    1ILL    1ITE    1ITI    1ITL    1ITM    1RCB    2B8U    2B8X    2B8Y    2B8Z    2B90    2B91    2CYK    2D48    2INT    3BPL    3BPN    3QB7    4YDY    5FHX   
Structural Biology KnowledgeBase1BBN    1BCN    1CYL    1HIJ    1HIK    1HZI    1IAR    1ILL    1ITE    1ITI    1ITL    1ITM    1RCB    2B8U    2B8X    2B8Y    2B8Z    2B90    2B91    2CYK    2D48    2INT    3BPL    3BPN    3QB7    4YDY    5FHX   
SCOP (Structural Classification of Proteins)1BBN    1BCN    1CYL    1HIJ    1HIK    1HZI    1IAR    1ILL    1ITE    1ITI    1ITL    1ITM    1RCB    2B8U    2B8X    2B8Y    2B8Z    2B90    2B91    2CYK    2D48    2INT    3BPL    3BPN    3QB7    4YDY    5FHX   
CATH (Classification of proteins structures)1BBN    1BCN    1CYL    1HIJ    1HIK    1HZI    1IAR    1ILL    1ITE    1ITI    1ITL    1ITM    1RCB    2B8U    2B8X    2B8Y    2B8Z    2B90    2B91    2CYK    2D48    2INT    3BPL    3BPN    3QB7    4YDY    5FHX   
SuperfamilyP05112
Human Protein Atlas [tissue]ENSG00000113520-IL4 [tissue]
Peptide AtlasP05112
HPRD00989
IPIIPI00007081   IPI00217945   
Protein Interaction databases
DIP (DOE-UCLA)P05112
IntAct (EBI)P05112
FunCoupENSG00000113520
BioGRIDIL4
STRING (EMBL)IL4
ZODIACIL4
Ontologies - Pathways
QuickGOP05112
Ontology : AmiGOcytokine activity  interleukin-4 receptor binding  protein binding  extracellular region  extracellular space  immune response  growth factor activity  cholesterol metabolic process  regulation of signaling receptor activity  positive regulation of gene expression  negative regulation of epithelial cell migration  positive regulation of macroautophagy  cytokine-mediated signaling pathway  B cell differentiation  positive regulation of B cell proliferation  positive regulation of interleukin-13 production  T-helper 2 cell cytokine production  type 2 immune response  positive regulation of T cell proliferation  T cell activation  regulation of phosphorylation  positive regulation of tyrosine phosphorylation of STAT protein  activation of Janus kinase activity  myeloid dendritic cell differentiation  negative regulation of apoptotic process  connective tissue growth factor biosynthetic process  regulation of isotype switching  positive regulation of MHC class II biosynthetic process  positive regulation of T cell differentiation  negative regulation of osteoclast differentiation  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  positive regulation of isotype switching to IgE isotypes  positive regulation of isotype switching to IgG isotypes  regulation of immune response  dendritic cell differentiation  positive regulation of cold-induced thermogenesis  negative regulation of complement-dependent cytotoxicity  negative regulation of endothelial cell apoptotic process  
Ontology : EGO-EBIcytokine activity  interleukin-4 receptor binding  protein binding  extracellular region  extracellular space  immune response  growth factor activity  cholesterol metabolic process  regulation of signaling receptor activity  positive regulation of gene expression  negative regulation of epithelial cell migration  positive regulation of macroautophagy  cytokine-mediated signaling pathway  B cell differentiation  positive regulation of B cell proliferation  positive regulation of interleukin-13 production  T-helper 2 cell cytokine production  type 2 immune response  positive regulation of T cell proliferation  T cell activation  regulation of phosphorylation  positive regulation of tyrosine phosphorylation of STAT protein  activation of Janus kinase activity  myeloid dendritic cell differentiation  negative regulation of apoptotic process  connective tissue growth factor biosynthetic process  regulation of isotype switching  positive regulation of MHC class II biosynthetic process  positive regulation of T cell differentiation  negative regulation of osteoclast differentiation  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  positive regulation of isotype switching to IgE isotypes  positive regulation of isotype switching to IgG isotypes  regulation of immune response  dendritic cell differentiation  positive regulation of cold-induced thermogenesis  negative regulation of complement-dependent cytotoxicity  negative regulation of endothelial cell apoptotic process  
Pathways : KEGGCytokine-cytokine receptor interaction    PI3K-Akt signaling pathway    Jak-STAT signaling pathway    Hematopoietic cell lineage    T cell receptor signaling pathway    Fc epsilon RI signaling pathway    Intestinal immune network for IgA production    Leishmaniasis    Measles    Asthma    Autoimmune thyroid disease    Inflammatory bowel disease (IBD)    Allograft rejection   
NDEx NetworkIL4
Atlas of Cancer Signalling NetworkIL4
Wikipedia pathwaysIL4
Orthology - Evolution
OrthoDB3565
GeneTree (enSembl)ENSG00000113520
Phylogenetic Trees/Animal Genes : TreeFamIL4
HOGENOMP05112
Homologs : HomoloGeneIL4
Homology/Alignments : Family Browser (UCSC)IL4
Gene fusions - Rearrangements
Fusion : QuiverIL4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerIL4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)IL4
dbVarIL4
ClinVarIL4
1000_GenomesIL4 
Exome Variant ServerIL4
ExAC (Exome Aggregation Consortium)ENSG00000113520
GNOMAD BrowserENSG00000113520
Varsome BrowserIL4
Genetic variants : HAPMAP3565
Genomic Variants (DGV)IL4 [DGVbeta]
DECIPHERIL4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisIL4 
Mutations
ICGC Data PortalIL4 
TCGA Data PortalIL4 
Broad Tumor PortalIL4
OASIS PortalIL4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICIL4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDIL4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)TBsLVD Tuberculosis susceptibility Locus Variation Database
BioMutasearch IL4
DgiDB (Drug Gene Interaction Database)IL4
DoCM (Curated mutations)IL4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)IL4 (select a term)
intoGenIL4
Cancer3DIL4(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM147780   
Orphanet
DisGeNETIL4
MedgenIL4
Genetic Testing Registry IL4
NextProtP05112 [Medical]
TSGene3565
GENETestsIL4
Target ValidationIL4
Huge Navigator IL4 [HugePedia]
snp3D : Map Gene to Disease3565
BioCentury BCIQIL4
ClinGenIL4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3565
Chemical/Pharm GKB GenePA197
Clinical trialIL4
Miscellaneous
canSAR (ICR)IL4 (select the gene name)
DataMed IndexIL4
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineIL4
EVEXIL4
GoPubMedIL4
iHOPIL4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Jan 17 18:17:56 CET 2019

For comments and suggestions or contributions, please contact us atlasgeneticsoncology@usal.es.