KLK3 (kallikrein related peptidase 3)

1. Identity

Alias_names
General Information
kallikrein 3
Alias_symbol (synonym)PSA
Other aliasKLK2A1
hK3
HGNC (Hugo) KLK3
LocusID (NCBI) 354
Atlas_Id 41083
Location 19q13.33  [Link to chromosome band 19q13]
Location_base_pair Starts at 50854915 and ends at 50860764 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FBRS (16p11.2) / KLK3 (19q13.33)KLK3 (19q13.33) / CACNB2 (10p12.33)KLK3 (19q13.33) / CDC42EP4 (17q25.1)
KLK3 (19q13.33) / GSN (9q33.2)KLK3 (19q13.33) / KLK3 (19q13.33)KLK3 (19q13.33) / LOC646329 ()
KLK3 (19q13.33) / MALAT1 (11q13.1)KLK3 (19q13.33) / PSMD7 (16q23.1)RORA (15q22.2) / KLK3 (19q13.33)
VPS4A (16q22.1) / KLK3 (19q13.33)ZC3H3 (8q24.3) / KLK3 (19q13.33)ZC3H3 8q24.3 / KLK3 19q13.33

2. DNA/RNA

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  Prostate tumors: an overview
t(8;19)(q24;q13) ZC3H3/KLK3


3. External links

Nomenclature
HGNC (Hugo)KLK3   6364
Cards
Entrez_Gene (NCBI)KLK3  354  kallikrein related peptidase 3
AliasesAPS; KLK2A1; PSA; hK3
GeneCards (Weizmann)KLK3
Ensembl hg19 (Hinxton)ENSG00000142515 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000142515 [Gene_View] &nbspENSG00000142515 [Sequence]  chr19:50854915-50860764 [Contig_View]  KLK3 [Vega]
ICGC DataPortalENSG00000142515
TCGA cBioPortalKLK3
AceView (NCBI)KLK3
Genatlas (Paris)KLK3
WikiGenes354
SOURCE (Princeton)KLK3
Genetics Home Reference (NIH)KLK3
Genomic and cartography
GoldenPath hg38 (UCSC)KLK3  -     chr19:50854915-50860764 +  19q13.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)KLK3  -     19q13.33   [Description]    (hg19-Feb_2009)
EnsemblKLK3 - 19q13.33 [CytoView hg19]  KLK3 - 19q13.33 [CytoView hg38]
Mapping of homologs : NCBIKLK3 [Mapview hg19]  KLK3 [Mapview hg38]
OMIM176820   
Gene and transcription
Genbank (Entrez)AF335477 AF335478 AJ310937 AJ310938 AJ459782
RefSeq transcript (Entrez)NM_001030047 NM_001030048 NM_001030049 NM_001030050 NM_001648
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)KLK3
Cluster EST : UnigeneHs.171995 [ NCBI ]
CGAP (NCI)Hs.171995
Alternative Splicing GalleryENSG00000142515
Gene ExpressionKLK3 [ NCBI-GEO ]   KLK3 [ EBI - ARRAY_EXPRESS ]   KLK3 [ SEEK ]   KLK3 [ MEM ]
Gene Expression Viewer (FireBrowse)KLK3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets] &nbsp [Normal Tissue Atlas] &nbsp[carcinoma Classsification] &nbsp[NCI60]
GenevestigatorExpression in : [tissues] &nbsp[cell-lines] &nbsp[cancer] &nbsp[perturbations] &nbsp
BioGPS (Tissue expression)354
GTEX Portal (Tissue expression)KLK3
Human Protein AtlasENSG00000142515-KLK3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP07288   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP07288  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP07288
Splice isoforms : SwissVarP07288
Catalytic activity : Enzyme3.4.21.77 [ Enzyme-Expasy ]   3.4.21.773.4.21.77 [ IntEnz-EBI ]   3.4.21.77 [ BRENDA ]   3.4.21.77 [ KEGG ]   
PhosPhoSitePlusP07288
Domaine pattern : Prosite (Expaxy)TRYPSIN_DOM (PS50240)    TRYPSIN_HIS (PS00134)    TRYPSIN_SER (PS00135)   
Domains : Interpro (EBI)Peptidase_S1_PA    Peptidase_S1A    Trypsin_dom    TRYPSIN_HIS    TRYPSIN_SER   
Domain families : Pfam (Sanger)Trypsin (PF00089)   
Domain families : Pfam (NCBI)pfam00089   
Domain families : Smart (EMBL)Tryp_SPc (SM00020)  
Conserved Domain (NCBI)KLK3
DMDM Disease mutations354
Blocks (Seattle)KLK3
PDB (RSDB)1PFA    2PSA    2ZCH    2ZCK    2ZCL    3QUM   
PDB Europe1PFA    2PSA    2ZCH    2ZCK    2ZCL    3QUM   
PDB (PDBSum)1PFA    2PSA    2ZCH    2ZCK    2ZCL    3QUM   
PDB (IMB)1PFA    2PSA    2ZCH    2ZCK    2ZCL    3QUM   
Structural Biology KnowledgeBase1PFA    2PSA    2ZCH    2ZCK    2ZCL    3QUM   
SCOP (Structural Classification of Proteins)1PFA    2PSA    2ZCH    2ZCK    2ZCL    3QUM   
CATH (Classification of proteins structures)1PFA    2PSA    2ZCH    2ZCK    2ZCL    3QUM   
SuperfamilyP07288
Human Protein Atlas [tissue]ENSG00000142515-KLK3 [tissue]
Peptide AtlasP07288
HPRD01461
IPIIPI00010858   IPI00383517   IPI00386036   IPI00102806   IPI00386209   IPI00040297   IPI00640523   
Protein Interaction databases
DIP (DOE-UCLA)P07288
IntAct (EBI)P07288
FunCoupENSG00000142515
BioGRIDKLK3
STRING (EMBL)KLK3
ZODIACKLK3
Ontologies - Pathways
QuickGOP07288
Ontology : AmiGOantibacterial peptide production  regulation of systemic arterial blood pressure  endopeptidase activity  serine-type endopeptidase activity  serine-type endopeptidase activity  protein binding  extracellular region  extracellular region  extracellular space  nucleus  proteolysis  serine-type peptidase activity  negative regulation of angiogenesis  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides  secretory granule  zymogen activation  protein-containing complex  cellular protein metabolic process  extracellular exosome  
Ontology : EGO-EBIantibacterial peptide production  regulation of systemic arterial blood pressure  endopeptidase activity  serine-type endopeptidase activity  serine-type endopeptidase activity  protein binding  extracellular region  extracellular region  extracellular space  nucleus  proteolysis  serine-type peptidase activity  negative regulation of angiogenesis  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides  secretory granule  zymogen activation  protein-containing complex  cellular protein metabolic process  extracellular exosome  
Pathways : KEGGPathways in cancer    Prostate cancer   
NDEx NetworkKLK3
Atlas of Cancer Signalling NetworkKLK3
Wikipedia pathwaysKLK3
Orthology - Evolution
OrthoDB354
GeneTree (enSembl)ENSG00000142515
Phylogenetic Trees/Animal Genes : TreeFamKLK3
HOGENOMP07288
Homologs : HomoloGeneKLK3
Homology/Alignments : Family Browser (UCSC)KLK3
Gene fusions - Rearrangements
Fusion : MitelmanZC3H3/KLK3 [8q24.3/19q13.33] &nbsp[t(8;19)(q24;q13)]  
Fusion PortalZC3H3 8q24.3 KLK3 19q13.33 BRCA
Fusion : QuiverKLK3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerKLK3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)KLK3
dbVarKLK3
ClinVarKLK3
1000_GenomesKLK3 
Exome Variant ServerKLK3
ExAC (Exome Aggregation Consortium)ENSG00000142515
GNOMAD BrowserENSG00000142515
Varsome BrowserKLK3
Genetic variants : HAPMAP354
Genomic Variants (DGV)KLK3 [DGVbeta]
DECIPHERKLK3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisKLK3 
Mutations
ICGC Data PortalKLK3 
TCGA Data PortalKLK3 
Broad Tumor PortalKLK3
OASIS PortalKLK3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICKLK3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDKLK3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch KLK3
DgiDB (Drug Gene Interaction Database)KLK3
DoCM (Curated mutations)KLK3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)KLK3 (select a term)
intoGenKLK3
Cancer3DKLK3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM176820   
Orphanet
DisGeNETKLK3
MedgenKLK3
Genetic Testing Registry KLK3
NextProtP07288 [Medical]
TSGene354
GENETestsKLK3
Target ValidationKLK3
Huge Navigator KLK3 [HugePedia]
snp3D : Map Gene to Disease354
BioCentury BCIQKLK3
ClinGenKLK3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD354
Chemical/Pharm GKB GenePA164741810
Clinical trialKLK3
Miscellaneous
canSAR (ICR)KLK3 (select the gene name)
DataMed IndexKLK3
Probes
Litterature
PubMed422 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineKLK3
EVEXKLK3
GoPubMedKLK3
iHOPKLK3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Jan 17 18:19:32 CET 2019

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