NXF1 (nuclear RNA export factor 1)

1. Identity

Alias_symbol (synonym)
General Information
Mex67
DKFZp667O0311
Other aliasMEX67
HGNC (Hugo) NXF1
LocusID (NCBI) 10482
Atlas_Id 46831
Location 11q12.3  [Link to chromosome band 11q12]
Location_base_pair Starts at 62792126 and ends at 62805492 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
IST1 (16q22.2) / NXF1 (11q12.3)LOC100507412 (-) / NXF1 (11q12.3)NFKBID (19q13.12) / NXF1 (11q12.3)
NXF1 (11q12.3) / C1orf168 (1p32.2)NXF1 (11q12.3) / CLEC18A (16q22.1)NXF1 (11q12.3) / WDR74 (11q12.3)
NXF1 (11q12.3) / ZNF609 (15q22.31)SLC3A2 (11q12.3) / NXF1 (11q12.3)NXF1 11q12.3 / WDR74 11q12.3
SLC3A2 11q12.3 / NXF1 11q12.3

2. DNA/RNA

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

 

3. Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]

  t(11;11)(q12;q12) NXF1/GANAB

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  NXF1/WDR74 (11q12)
SLC3A2/NXF1 (11q12)

4. External links

Nomenclature
HGNC (Hugo)NXF1   8071
Cards
Entrez_Gene (NCBI)NXF1  10482  nuclear RNA export factor 1
AliasesMEX67; TAP
GeneCards (Weizmann)NXF1
Ensembl hg19 (Hinxton)ENSG00000162231 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000162231 [Gene_View] &nbspENSG00000162231 [Sequence]  chr11:62792126-62805492 [Contig_View]  NXF1 [Vega]
ICGC DataPortalENSG00000162231
TCGA cBioPortalNXF1
AceView (NCBI)NXF1
Genatlas (Paris)NXF1
WikiGenes10482
SOURCE (Princeton)NXF1
Genetics Home Reference (NIH)NXF1
Genomic and cartography
GoldenPath hg38 (UCSC)NXF1  -     chr11:62792126-62805492 -  11q12.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NXF1  -     11q12.3   [Description]    (hg19-Feb_2009)
EnsemblNXF1 - 11q12.3 [CytoView hg19]  NXF1 - 11q12.3 [CytoView hg38]
Mapping of homologs : NCBINXF1 [Mapview hg19]  NXF1 [Mapview hg38]
OMIM602647   
Gene and transcription
Genbank (Entrez)AB209915 AF112880 AF126246 AJ132712 AK027192
RefSeq transcript (Entrez)NM_001081491 NM_006362
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NXF1
Cluster EST : UnigeneHs.601546 [ NCBI ]
CGAP (NCI)Hs.601546
Alternative Splicing GalleryENSG00000162231
Gene ExpressionNXF1 [ NCBI-GEO ]   NXF1 [ EBI - ARRAY_EXPRESS ]   NXF1 [ SEEK ]   NXF1 [ MEM ]
Gene Expression Viewer (FireBrowse)NXF1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets] &nbsp [Normal Tissue Atlas] &nbsp[carcinoma Classsification] &nbsp[NCI60]
GenevestigatorExpression in : [tissues] &nbsp[cell-lines] &nbsp[cancer] &nbsp[perturbations] &nbsp
BioGPS (Tissue expression)10482
GTEX Portal (Tissue expression)NXF1
Human Protein AtlasENSG00000162231-NXF1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UBU9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UBU9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UBU9
Splice isoforms : SwissVarQ9UBU9
PhosPhoSitePlusQ9UBU9
Domaine pattern : Prosite (Expaxy)LRR (PS51450)    NTF2_DOMAIN (PS50177)    TAP_C (PS51281)   
Domains : Interpro (EBI)Leu-rich_rpt    LRR_dom_sf    NTF2    NTF2-like_dom_sf    Nuclear_transport_factor_2_euk    Nucleotide-bd_a/b_plait_sf    NXF_fam    RBD_domain_sf    TAP_C_dom    Tap_RNA-bd    UBA-like_sf   
Domain families : Pfam (Sanger)NTF2 (PF02136)    Tap-RNA_bind (PF09162)    TAP_C (PF03943)   
Domain families : Pfam (NCBI)pfam02136    pfam09162    pfam03943   
Domain families : Smart (EMBL)TAP_C (SM00804)  
Domain structure : Prodom (Prabi Lyon)Tap_RNA_bd (PD043466)   
Conserved Domain (NCBI)NXF1
DMDM Disease mutations10482
Blocks (Seattle)NXF1
PDB (RSDB)1FO1    1FT8    1GO5    1JKG    1JN5    1KOH    1KOO    1OAI    2Z5K    2Z5M    3RW6    3RW7    4WYK   
PDB Europe1FO1    1FT8    1GO5    1JKG    1JN5    1KOH    1KOO    1OAI    2Z5K    2Z5M    3RW6    3RW7    4WYK   
PDB (PDBSum)1FO1    1FT8    1GO5    1JKG    1JN5    1KOH    1KOO    1OAI    2Z5K    2Z5M    3RW6    3RW7    4WYK   
PDB (IMB)1FO1    1FT8    1GO5    1JKG    1JN5    1KOH    1KOO    1OAI    2Z5K    2Z5M    3RW6    3RW7    4WYK   
Structural Biology KnowledgeBase1FO1    1FT8    1GO5    1JKG    1JN5    1KOH    1KOO    1OAI    2Z5K    2Z5M    3RW6    3RW7    4WYK   
SCOP (Structural Classification of Proteins)1FO1    1FT8    1GO5    1JKG    1JN5    1KOH    1KOO    1OAI    2Z5K    2Z5M    3RW6    3RW7    4WYK   
CATH (Classification of proteins structures)1FO1    1FT8    1GO5    1JKG    1JN5    1KOH    1KOO    1OAI    2Z5K    2Z5M    3RW6    3RW7    4WYK   
SuperfamilyQ9UBU9
Human Protein Atlas [tissue]ENSG00000162231-NXF1 [tissue]
Peptide AtlasQ9UBU9
HPRD04035
IPIIPI00033153   IPI00749024   IPI00978175   IPI00979572   IPI00982833   IPI00978870   
Protein Interaction databases
DIP (DOE-UCLA)Q9UBU9
IntAct (EBI)Q9UBU9
FunCoupENSG00000162231
BioGRIDNXF1
STRING (EMBL)NXF1
ZODIACNXF1
Ontologies - Pathways
QuickGOQ9UBU9
Ontology : AmiGOtranscription export complex  RNA binding  RNA binding  mRNA binding  protein binding  nucleus  nucleus  nuclear pore  nucleoplasm  nucleoplasm  cytoplasm  cytosol  RNA export from nucleus  mRNA export from nucleus  mRNA export from nucleus  viral process  nuclear speck  poly(A)+ mRNA export from nucleus  nuclear inclusion body  
Ontology : EGO-EBItranscription export complex  RNA binding  RNA binding  mRNA binding  protein binding  nucleus  nucleus  nuclear pore  nucleoplasm  nucleoplasm  cytoplasm  cytosol  RNA export from nucleus  mRNA export from nucleus  mRNA export from nucleus  viral process  nuclear speck  poly(A)+ mRNA export from nucleus  nuclear inclusion body  
Pathways : KEGGRibosome biogenesis in eukaryotes    RNA transport    mRNA surveillance pathway    Influenza A    Herpes simplex infection   
NDEx NetworkNXF1
Atlas of Cancer Signalling NetworkNXF1
Wikipedia pathwaysNXF1
Orthology - Evolution
OrthoDB10482
GeneTree (enSembl)ENSG00000162231
Phylogenetic Trees/Animal Genes : TreeFamNXF1
HOGENOMQ9UBU9
Homologs : HomoloGeneNXF1
Homology/Alignments : Family Browser (UCSC)NXF1
Gene fusions - Rearrangements
Fusion : MitelmanNXF1/WDR74 [11q12.3/11q12.3] &nbsp
Fusion : MitelmanSLC3A2/NXF1 [11q12.3/11q12.3] &nbsp[t(11;11)(q12;q12)]  
Fusion PortalNXF1 11q12.3 WDR74 11q12.3 LUSC
Fusion PortalSLC3A2 11q12.3 NXF1 11q12.3 BRCA
Fusion Cancer (Beijing)NXF1 [11q12.3]  -  C1orf168 [1p32.2]  [FUSC004618]
Fusion : QuiverNXF1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNXF1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NXF1
dbVarNXF1
ClinVarNXF1
1000_GenomesNXF1 
Exome Variant ServerNXF1
ExAC (Exome Aggregation Consortium)ENSG00000162231
GNOMAD BrowserENSG00000162231
Varsome BrowserNXF1
Genetic variants : HAPMAP10482
Genomic Variants (DGV)NXF1 [DGVbeta]
DECIPHERNXF1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNXF1 
Mutations
ICGC Data PortalNXF1 
TCGA Data PortalNXF1 
Broad Tumor PortalNXF1
OASIS PortalNXF1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNXF1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDNXF1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NXF1
DgiDB (Drug Gene Interaction Database)NXF1
DoCM (Curated mutations)NXF1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NXF1 (select a term)
intoGenNXF1
Cancer3DNXF1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602647   
Orphanet
DisGeNETNXF1
MedgenNXF1
Genetic Testing Registry NXF1
NextProtQ9UBU9 [Medical]
TSGene10482
GENETestsNXF1
Target ValidationNXF1
Huge Navigator NXF1 [HugePedia]
snp3D : Map Gene to Disease10482
BioCentury BCIQNXF1
ClinGenNXF1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10482
Chemical/Pharm GKB GenePA31858
Clinical trialNXF1
Miscellaneous
canSAR (ICR)NXF1 (select the gene name)
DataMed IndexNXF1
Probes
Litterature
PubMed108 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNXF1
EVEXNXF1
GoPubMedNXF1
iHOPNXF1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Jan 17 18:28:49 CET 2019

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