RAD51B (RAD51 paralog B)

1. Identity

Alias_names
General Information
RAD51 (S. cerevisiae)-like 1
RAD51-like 1 (S. cerevisiae)
RAD51 homolog B (S. cerevisiae)
Alias_symbol (synonym)REC2
hREC2
R51H2
Other alias
HGNC (Hugo) RAD51B
LocusID (NCBI) 5890
Atlas_Id 52276
Location 14q24.1  [Link to chromosome band 14q24]
Location_base_pair Starts at 67819779 and ends at 68478093 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AFF1 (4q21.3) / RAD51B (14q24.1)ASAP1 (8q24.21) / RAD51B (14q24.1)ATAD2 (8q24.13) / RAD51B (14q24.1)
CEP170 (1q43) / RAD51B (14q24.1)CHD9 (16q12.2) / RAD51B (14q24.1)DCAF5 (14q24.1) / RAD51B (14q24.1)
HMGA2 (12q14.3) / RAD51B (14q24.1)MPP5 (14q23.3) / RAD51B (14q24.1)NECTIN2 (19q13.32) / RAD51B (14q24.1)
NPC2 (14q24.3) / RAD51B (14q24.1)PCNX1 (14q24.2) / RAD51B (14q24.1)RAB40C (16p13.3) / RAD51B (14q24.1)
RAD51B (14q24.1) / BMP2 (20p12.3)RAD51B (14q24.1) / DACT1 (14q23.1)RAD51B (14q24.1) / DCAF5 (14q24.1)
RAD51B (14q24.1) / FNDC3B (3q26.31)RAD51B (14q24.1) / HMGA2 (12q14.3)RAD51B (14q24.1) / KMT2A (11q23.3)
RAD51B (14q24.1) / OPHN1 (Xq12)RAD51B (14q24.1) / PLAG1 (8q12.1)RAD51B (14q24.1) / RAD51B (14q24.1)
RAD51B (14q24.1) / RPSAP52 (12q14.3)RAD51B (14q24.1) / RRAGB (Xp11.21)RAD51B (14q24.1) / UVRAG (11q13.5)
SLC39A9 (14q24.1) / RAD51B (14q24.1)SUSD6 (14q24.1) / RAD51B (14q24.1)UVRAG (11q13.5) / RAD51B (14q24.1)
ZFYVE26 (14q24.1) / RAD51B (14q24.1)ZZZ3 (1p31.1) / RAD51B (14q24.1)HMGA2 RAD51B
RAD51B HMGA2ASAP1 8q24.21 / RAD51B 14q24.1ATAD2 8q24.13 / RAD51B 14q24.1
CHD9 16q12.2 / RAD51B 14q24.1KIAA0247 RAD51B 14q24.1MPP5 14q23.3 / RAD51B 14q24.1
NPC2 14q24.3 / RAD51B 14q24.1PCNX 14q24.2 / RAD51B 14q24.1RAB40C 16p13.3 / RAD51B 14q24.1
RAD51B 14q24.1 / DACT1 14q23.1RAD51B 14q24.1 / DCAF5 14q24.1RAD51B 14q24.1 / UVRAG 11q13.5
SLC39A9 14q24.1 / RAD51B 14q24.1UVRAG 11q13.5 / RAD51B 14q24.1ZFYVE26 14q24.1 / RAD51B 14q24.1

2. DNA/RNA

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

 

3. Other Leukemias implicated (Data extracted from papers in the Atlas) [ 3 ]

4. External links

Nomenclature
HGNC (Hugo)RAD51B   9822
Cards
Entrez_Gene (NCBI)RAD51B  5890  RAD51 paralog B
AliasesR51H2; RAD51L1; REC2
GeneCards (Weizmann)RAD51B
Ensembl hg19 (Hinxton)ENSG00000182185 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000182185 [Gene_View] &nbspENSG00000182185 [Sequence]  chr14:67819779-68478093 [Contig_View]  RAD51B [Vega]
ICGC DataPortalENSG00000182185
TCGA cBioPortalRAD51B
AceView (NCBI)RAD51B
Genatlas (Paris)RAD51B
WikiGenes5890
SOURCE (Princeton)RAD51B
Genetics Home Reference (NIH)RAD51B
Genomic and cartography
GoldenPath hg38 (UCSC)RAD51B  -     chr14:67819779-68478093 +  14q24.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RAD51B  -     14q24.1   [Description]    (hg19-Feb_2009)
EnsemblRAD51B - 14q24.1 [CytoView hg19]  RAD51B - 14q24.1 [CytoView hg38]
Mapping of homologs : NCBIRAD51B [Mapview hg19]  RAD51B [Mapview hg38]
OMIM602948   
Gene and transcription
Genbank (Entrez)AK130466 AK309787 AK310686 AL597484 BC030219
RefSeq transcript (Entrez)NM_001321809 NM_001321810 NM_001321812 NM_001321814 NM_001321815 NM_001321817 NM_001321818 NM_001321819 NM_001321821 NM_002877 NM_133509 NM_133510
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RAD51B
Cluster EST : UnigeneHs.172587 [ NCBI ]
CGAP (NCI)Hs.172587
Alternative Splicing GalleryENSG00000182185
Gene ExpressionRAD51B [ NCBI-GEO ]   RAD51B [ EBI - ARRAY_EXPRESS ]   RAD51B [ SEEK ]   RAD51B [ MEM ]
Gene Expression Viewer (FireBrowse)RAD51B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets] &nbsp [Normal Tissue Atlas] &nbsp[carcinoma Classsification] &nbsp[NCI60]
GenevestigatorExpression in : [tissues] &nbsp[cell-lines] &nbsp[cancer] &nbsp[perturbations] &nbsp
BioGPS (Tissue expression)5890
GTEX Portal (Tissue expression)RAD51B
Human Protein AtlasENSG00000182185-RAD51B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO15315   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO15315  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO15315
Splice isoforms : SwissVarO15315
PhosPhoSitePlusO15315
Domaine pattern : Prosite (Expaxy)RECA_2 (PS50162)   
Domains : Interpro (EBI)AAA+_ATPase    DNA_recomb/repair_Rad51_C    DNA_recomb/repair_RecA-like    P-loop_NTPase    Rad51_DMC1_RadA    RAD51B    RecA_ATP-bd   
Domain families : Pfam (Sanger)Rad51 (PF08423)   
Domain families : Pfam (NCBI)pfam08423   
Domain families : Smart (EMBL)AAA (SM00382)  
Conserved Domain (NCBI)RAD51B
DMDM Disease mutations5890
Blocks (Seattle)RAD51B
SuperfamilyO15315
Human Protein Atlas [tissue]ENSG00000182185-RAD51B [tissue]
Peptide AtlasO15315
HPRD04255
IPIIPI00006105   IPI00220523   IPI00395987   IPI00386489   IPI00386490   IPI01025586   IPI01026198   IPI00945688   IPI00945151   IPI00947303   
Protein Interaction databases
DIP (DOE-UCLA)O15315
IntAct (EBI)O15315
FunCoupENSG00000182185
BioGRIDRAD51B
STRING (EMBL)RAD51B
ZODIACRAD51B
Ontologies - Pathways
QuickGOO15315
Ontology : AmiGOfour-way junction DNA binding  four-way junction DNA binding  double-strand break repair via homologous recombination  double-strand break repair via homologous recombination  DNA binding  double-stranded DNA binding  double-stranded DNA binding  single-stranded DNA binding  single-stranded DNA binding  protein binding  ATP binding  nucleus  nucleoplasm  replication fork  replication fork  DNA repair  DNA recombination  reciprocal meiotic recombination  blood coagulation  DNA-dependent ATPase activity  DNA-dependent ATPase activity  positive regulation of G2/M transition of mitotic cell cycle  Rad51B-Rad51C-Rad51D-XRCC2 complex  Rad51B-Rad51C-Rad51D-XRCC2 complex  
Ontology : EGO-EBIfour-way junction DNA binding  four-way junction DNA binding  double-strand break repair via homologous recombination  double-strand break repair via homologous recombination  DNA binding  double-stranded DNA binding  double-stranded DNA binding  single-stranded DNA binding  single-stranded DNA binding  protein binding  ATP binding  nucleus  nucleoplasm  replication fork  replication fork  DNA repair  DNA recombination  reciprocal meiotic recombination  blood coagulation  DNA-dependent ATPase activity  DNA-dependent ATPase activity  positive regulation of G2/M transition of mitotic cell cycle  Rad51B-Rad51C-Rad51D-XRCC2 complex  Rad51B-Rad51C-Rad51D-XRCC2 complex  
Pathways : KEGGHomologous recombination   
NDEx NetworkRAD51B
Atlas of Cancer Signalling NetworkRAD51B
Wikipedia pathwaysRAD51B
Orthology - Evolution
OrthoDB5890
GeneTree (enSembl)ENSG00000182185
Phylogenetic Trees/Animal Genes : TreeFamRAD51B
HOGENOMO15315
Homologs : HomoloGeneRAD51B
Homology/Alignments : Family Browser (UCSC)RAD51B
Gene fusions - Rearrangements
Fusion : MitelmanASAP1/RAD51B [8q24.21/14q24.1] &nbsp[t(8;14)(q24;q24)]  
Fusion : MitelmanATAD2/RAD51B [8q24.13/14q24.1] &nbsp[t(8;14)(q24;q24)]  
Fusion : MitelmanCEP170/RAD51B [1q43/14q24.1] &nbsp[t(1;14)(q43;q24)]  
Fusion : MitelmanCHD9/RAD51B [16q12.2/14q24.1] &nbsp[t(14;16)(q24;q12)]  
Fusion : MitelmanHMGA2/RAD51B [12q14.3/14q24.1] &nbsp[t(12;14)(q14;q24)]  
Fusion : MitelmanMPP5/RAD51B [14q23.3/14q24.1] &nbsp[t(14;14)(q23;q24)]  
Fusion : MitelmanNPC2/RAD51B [14q24.3/14q24.1] &nbsp[t(14;14)(q24;q24)]  
Fusion : MitelmanPCNX/RAD51B [14q24.2/14q24.1] &nbsp[t(14;14)(q24;q24)]  
Fusion : MitelmanRAB40C/RAD51B [16p13.3/14q24.1] &nbsp[t(14;16)(q24;p13)]  
Fusion : MitelmanRAD51B/DACT1 [14q24.1/14q23.1] &nbsp[t(14;14)(q23;q24)]  
Fusion : MitelmanRAD51B/DCAF5 [14q24.1/14q24.1] &nbsp[t(14;14)(q24;q24)]  
Fusion : MitelmanRAD51B/PLAG1 [14q24.1/8q12.1] &nbsp[t(8;14)(q12;q24)]  
Fusion : MitelmanRAD51B/UVRAG [14q24.1/11q13.5] &nbsp[t(11;14)(q13;q24)]  
Fusion : MitelmanSLC39A9/RAD51B [14q24.1/14q24.1] &nbsp[t(14;14)(q24;q24)]  
Fusion : MitelmanSUSD6/RAD51B [14q24.1/14q24.1] &nbsp[t(14;14)(q24;q24)]  
Fusion : MitelmanUVRAG/RAD51B [11q13.5/14q24.1] &nbsp[t(11;14)(q13;q24)]  
Fusion : MitelmanZFYVE26/RAD51B [14q24.1/14q24.1] &nbsp[t(14;14)(q24;q24)]  
Fusion PortalASAP1 8q24.21 RAD51B 14q24.1 LUAD
Fusion PortalATAD2 8q24.13 RAD51B 14q24.1 BRCA
Fusion PortalCHD9 16q12.2 RAD51B 14q24.1 BRCA
Fusion PortalKIAA0247 RAD51B 14q24.1 BRCA
Fusion PortalMPP5 14q23.3 RAD51B 14q24.1 BRCA
Fusion PortalNPC2 14q24.3 RAD51B 14q24.1 BRCA
Fusion PortalPCNX 14q24.2 RAD51B 14q24.1 LUAD
Fusion PortalRAB40C 16p13.3 RAD51B 14q24.1 OV
Fusion PortalRAD51B 14q24.1 DACT1 14q23.1 HNSC
Fusion PortalRAD51B 14q24.1 DCAF5 14q24.1 BRCA
Fusion PortalRAD51B 14q24.1 UVRAG 11q13.5 BRCA
Fusion PortalSLC39A9 14q24.1 RAD51B 14q24.1 BRCA
Fusion PortalUVRAG 11q13.5 RAD51B 14q24.1 BRCA
Fusion PortalZFYVE26 14q24.1 RAD51B 14q24.1 BRCA
Fusion : QuiverRAD51B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRAD51B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RAD51B
dbVarRAD51B
ClinVarRAD51B
1000_GenomesRAD51B 
Exome Variant ServerRAD51B
ExAC (Exome Aggregation Consortium)ENSG00000182185
GNOMAD BrowserENSG00000182185
Varsome BrowserRAD51B
Genetic variants : HAPMAP5890
Genomic Variants (DGV)RAD51B [DGVbeta]
DECIPHERRAD51B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRAD51B 
Mutations
ICGC Data PortalRAD51B 
TCGA Data PortalRAD51B 
Broad Tumor PortalRAD51B
OASIS PortalRAD51B [ Somatic mutations - Copy number]
Cancer Gene: CensusRAD51B 
Somatic Mutations in Cancer : COSMICRAD51B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRAD51B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RAD51B
DgiDB (Drug Gene Interaction Database)RAD51B
DoCM (Curated mutations)RAD51B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RAD51B (select a term)
intoGenRAD51B
Cancer3DRAD51B(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602948   
Orphanet
DisGeNETRAD51B
MedgenRAD51B
Genetic Testing Registry RAD51B
NextProtO15315 [Medical]
TSGene5890
GENETestsRAD51B
Target ValidationRAD51B
Huge Navigator RAD51B [HugePedia]
snp3D : Map Gene to Disease5890
BioCentury BCIQRAD51B
ClinGenRAD51B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5890
Chemical/Pharm GKB GenePA34178
Clinical trialRAD51B
Miscellaneous
canSAR (ICR)RAD51B (select the gene name)
DataMed IndexRAD51B
Probes
Litterature
PubMed86 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRAD51B
EVEXRAD51B
GoPubMedRAD51B
iHOPRAD51B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jan 17 18:34:16 CET 2019

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