RARS2 (arginyl-tRNA synthetase 2, mitochondrial)

1. Identity

Alias_names
General Information
arginyl-tRNA synthetase-like
Alias_symbol (synonym)MGC14993
MGC23778
PRO1992
dJ382I10.6
DALRD2
Other aliasArgRS
PCH6
HGNC (Hugo) RARS2
LocusID (NCBI) 57038
Atlas_Id 72491
Location 6q15  [Link to chromosome band 6q15]
Location_base_pair Starts at 87513935 and ends at 87590032 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
C7orf31 (7p15.3) / RARS2 (6q15)MAP1B (5q13.2) / RARS2 (6q15)RARS2 (6q15) / HECA (6q24.1)
RARS2 (6q15) / RARS2 (6q15)RARS2 (6q15) / SMAP1 (6q13)

2. DNA/RNA

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

 

3. External links

Nomenclature
HGNC (Hugo)RARS2   21406
Cards
Entrez_Gene (NCBI)RARS2  57038  arginyl-tRNA synthetase 2, mitochondrial
AliasesArgRS; DALRD2; PCH6; PRO1992; 
RARSL
GeneCards (Weizmann)RARS2
Ensembl hg19 (Hinxton)ENSG00000146282 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000146282 [Gene_View] &nbspENSG00000146282 [Sequence]  chr6:87513935-87590032 [Contig_View]  RARS2 [Vega]
ICGC DataPortalENSG00000146282
TCGA cBioPortalRARS2
AceView (NCBI)RARS2
Genatlas (Paris)RARS2
WikiGenes57038
SOURCE (Princeton)RARS2
Genetics Home Reference (NIH)RARS2
Genomic and cartography
GoldenPath hg38 (UCSC)RARS2  -     chr6:87513935-87590032 -  6q15   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RARS2  -     6q15   [Description]    (hg19-Feb_2009)
EnsemblRARS2 - 6q15 [CytoView hg19]  RARS2 - 6q15 [CytoView hg38]
Mapping of homologs : NCBIRARS2 [Mapview hg19]  RARS2 [Mapview hg38]
OMIM611523   611524   
Gene and transcription
Genbank (Entrez)AF118086 AF143874 AI610814 AK023550 AK093934
RefSeq transcript (Entrez)NM_001318785 NM_001350505 NM_001350506 NM_001350507 NM_001350508 NM_001350509 NM_001350510 NM_001350511 NM_020320
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RARS2
Cluster EST : UnigeneHs.485910 [ NCBI ]
CGAP (NCI)Hs.485910
Alternative Splicing GalleryENSG00000146282
Gene ExpressionRARS2 [ NCBI-GEO ]   RARS2 [ EBI - ARRAY_EXPRESS ]   RARS2 [ SEEK ]   RARS2 [ MEM ]
Gene Expression Viewer (FireBrowse)RARS2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets] &nbsp [Normal Tissue Atlas] &nbsp[carcinoma Classsification] &nbsp[NCI60]
GenevestigatorExpression in : [tissues] &nbsp[cell-lines] &nbsp[cancer] &nbsp[perturbations] &nbsp
BioGPS (Tissue expression)57038
GTEX Portal (Tissue expression)RARS2
Human Protein AtlasENSG00000146282-RARS2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ5T160   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ5T160  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ5T160
Splice isoforms : SwissVarQ5T160
Catalytic activity : Enzyme6.1.1.19 [ Enzyme-Expasy ]   6.1.1.196.1.1.19 [ IntEnz-EBI ]   6.1.1.19 [ BRENDA ]   6.1.1.19 [ KEGG ]   
PhosPhoSitePlusQ5T160
Domaine pattern : Prosite (Expaxy)AA_TRNA_LIGASE_I (PS00178)   
Domains : Interpro (EBI)aa-tRNA-synth_I_CS    Arg-tRNA-ligase    Arg-tRNA-synth_N    DALR_anticod-bd    Rossmann-like_a/b/a_fold    tRNAsynth_Ia_anticodon-bd   
Domain families : Pfam (Sanger)DALR_1 (PF05746)    tRNA-synt_1d (PF00750)   
Domain families : Pfam (NCBI)pfam05746    pfam00750   
Domain families : Smart (EMBL)DALR_1 (SM00836)  
Conserved Domain (NCBI)RARS2
DMDM Disease mutations57038
Blocks (Seattle)RARS2
SuperfamilyQ5T160
Human Protein Atlas [tissue]ENSG00000146282-RARS2 [tissue]
Peptide AtlasQ5T160
HPRD15209
IPIIPI00549566   IPI00384037   IPI00514101   
Protein Interaction databases
DIP (DOE-UCLA)Q5T160
IntAct (EBI)Q5T160
FunCoupENSG00000146282
BioGRIDRARS2
STRING (EMBL)RARS2
ZODIACRARS2
Ontologies - Pathways
QuickGOQ5T160
Ontology : AmiGORNA binding  arginine-tRNA ligase activity  arginine-tRNA ligase activity  ATP binding  mitochondrion  mitochondrial matrix  tRNA aminoacylation for protein translation  arginyl-tRNA aminoacylation  mitochondrial translation  
Ontology : EGO-EBIRNA binding  arginine-tRNA ligase activity  arginine-tRNA ligase activity  ATP binding  mitochondrion  mitochondrial matrix  tRNA aminoacylation for protein translation  arginyl-tRNA aminoacylation  mitochondrial translation  
NDEx NetworkRARS2
Atlas of Cancer Signalling NetworkRARS2
Wikipedia pathwaysRARS2
Orthology - Evolution
OrthoDB57038
GeneTree (enSembl)ENSG00000146282
Phylogenetic Trees/Animal Genes : TreeFamRARS2
HOVERGENQ5T160
HOGENOMQ5T160
Homologs : HomoloGeneRARS2
Homology/Alignments : Family Browser (UCSC)RARS2
Gene fusions - Rearrangements
Fusion : QuiverRARS2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRARS2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RARS2
dbVarRARS2
ClinVarRARS2
1000_GenomesRARS2 
Exome Variant ServerRARS2
ExAC (Exome Aggregation Consortium)ENSG00000146282
GNOMAD BrowserENSG00000146282
Varsome BrowserRARS2
Genetic variants : HAPMAP57038
Genomic Variants (DGV)RARS2 [DGVbeta]
DECIPHERRARS2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRARS2 
Mutations
ICGC Data PortalRARS2 
TCGA Data PortalRARS2 
Broad Tumor PortalRARS2
OASIS PortalRARS2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRARS2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRARS2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch RARS2
DgiDB (Drug Gene Interaction Database)RARS2
DoCM (Curated mutations)RARS2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RARS2 (select a term)
intoGenRARS2
Cancer3DRARS2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611523    611524   
Orphanet17610    3132   
DisGeNETRARS2
MedgenRARS2
Genetic Testing Registry RARS2
NextProtQ5T160 [Medical]
TSGene57038
GENETestsRARS2
Target ValidationRARS2
Huge Navigator RARS2 [HugePedia]
snp3D : Map Gene to Disease57038
BioCentury BCIQRARS2
ClinGenRARS2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD57038
Chemical/Pharm GKB GenePA162400662
Clinical trialRARS2
Miscellaneous
canSAR (ICR)RARS2 (select the gene name)
Probes
Litterature
PubMed22 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRARS2
EVEXRARS2
GoPubMedRARS2
iHOPRARS2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Jul 30 14:25:59 CEST 2018

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