RNF126 (ring finger protein 126)

1. Identity

Alias_symbol (synonym)
General Information
Other alias-
HGNC (Hugo) RNF126
LocusID (NCBI) 55658
Atlas_Id 46757
Location 19p13.3  [Link to chromosome band 19p13]
Location_base_pair Starts at 647526 and ends at 663233 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
LMO2 (11p13) / RNF126 (19p13.3)MKNK2 (19p13.3) / RNF126 (19p13.3)OAZ1 (19p13.3) / RNF126 (19p13.3)
RNF126 (19p13.3) / TSPAN4 (11p15.5)SHC2 (19p13.3) / RNF126 (19p13.3)MKNK2 19p13.3 / RNF126 19p13.3
SHC2 19p13.3 / RNF126 19p13.3

2. DNA/RNA

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

 


3. Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]

  t(19;19)(p13;p13) MKNK2/RNF126
t(19;19)(p13;p13) OAZ1/RNF126


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  RNF126/NDUFA11 (19p13)
SHC2/RNF126 (19p13)


4. External links

Nomenclature
HGNC (Hugo)RNF126   21151
Cards
Entrez_Gene (NCBI)RNF126  55658  ring finger protein 126
Aliases
GeneCards (Weizmann)RNF126
Ensembl hg19 (Hinxton)ENSG00000070423 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000070423 [Gene_View] &nbspENSG00000070423 [Sequence]  chr19:647526-663233 [Contig_View]  RNF126 [Vega]
ICGC DataPortalENSG00000070423
TCGA cBioPortalRNF126
AceView (NCBI)RNF126
Genatlas (Paris)RNF126
WikiGenes55658
SOURCE (Princeton)RNF126
Genetics Home Reference (NIH)RNF126
Genomic and cartography
GoldenPath hg38 (UCSC)RNF126  -     chr19:647526-663233 -  19p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RNF126  -     19p13.3   [Description]    (hg19-Feb_2009)
EnsemblRNF126 - 19p13.3 [CytoView hg19]  RNF126 - 19p13.3 [CytoView hg38]
Mapping of homologs : NCBIRNF126 [Mapview hg19]  RNF126 [Mapview hg38]
OMIM615177   
Gene and transcription
Genbank (Entrez)AK000559 AK289616 AL360265 BC001442 BC025374
RefSeq transcript (Entrez)NM_001366018 NM_017876 NM_194460
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RNF126
Cluster EST : UnigeneHs.69554 [ NCBI ]
CGAP (NCI)Hs.69554
Alternative Splicing GalleryENSG00000070423
Gene ExpressionRNF126 [ NCBI-GEO ]   RNF126 [ EBI - ARRAY_EXPRESS ]   RNF126 [ SEEK ]   RNF126 [ MEM ]
Gene Expression Viewer (FireBrowse)RNF126 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets] &nbsp [Normal Tissue Atlas] &nbsp[carcinoma Classsification] &nbsp[NCI60]
GenevestigatorExpression in : [tissues] &nbsp[cell-lines] &nbsp[cancer] &nbsp[perturbations] &nbsp
BioGPS (Tissue expression)55658
GTEX Portal (Tissue expression)RNF126
Human Protein AtlasENSG00000070423-RNF126 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BV68   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BV68  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BV68
Splice isoforms : SwissVarQ9BV68
PhosPhoSitePlusQ9BV68
Domaine pattern : Prosite (Expaxy)ZF_RING_2 (PS50089)   
Domains : Interpro (EBI)Znf_RING    Znf_RING/FYVE/PHD   
Domain families : Pfam (Sanger)zf-RING_2 (PF13639)   
Domain families : Pfam (NCBI)pfam13639   
Domain families : Smart (EMBL)RING (SM00184)  
Conserved Domain (NCBI)RNF126
DMDM Disease mutations55658
Blocks (Seattle)RNF126
PDB (RSDB)2N9O    2N9P   
PDB Europe2N9O    2N9P   
PDB (PDBSum)2N9O    2N9P   
PDB (IMB)2N9O    2N9P   
Structural Biology KnowledgeBase2N9O    2N9P   
SCOP (Structural Classification of Proteins)2N9O    2N9P   
CATH (Classification of proteins structures)2N9O    2N9P   
SuperfamilyQ9BV68
Human Protein Atlas [tissue]ENSG00000070423-RNF126 [tissue]
Peptide AtlasQ9BV68
HPRD11501
IPIIPI00155562   IPI00745921   
Protein Interaction databases
DIP (DOE-UCLA)Q9BV68
IntAct (EBI)Q9BV68
FunCoupENSG00000070423
BioGRIDRNF126
STRING (EMBL)RNF126
ZODIACRNF126
Ontologies - Pathways
QuickGOQ9BV68
Ontology : AmiGOepidermal growth factor receptor binding  protein binding  nucleus  nucleoplasm  cytoplasm  cytoplasm  cytosol  ubiquitin-dependent protein catabolic process  ubiquitin-dependent protein catabolic process  protein monoubiquitination  protein ubiquitination  negative regulation of epidermal growth factor receptor signaling pathway  regulation of cell proliferation  retrograde transport, endosome to Golgi  proteasome-mediated ubiquitin-dependent protein catabolic process  ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway  metal ion binding  ubiquitin protein ligase activity  ubiquitin protein ligase activity  protein K63-linked ubiquitination  protein K48-linked ubiquitination  cytoplasm protein quality control by the ubiquitin-proteasome system  
Ontology : EGO-EBIepidermal growth factor receptor binding  protein binding  nucleus  nucleoplasm  cytoplasm  cytoplasm  cytosol  ubiquitin-dependent protein catabolic process  ubiquitin-dependent protein catabolic process  protein monoubiquitination  protein ubiquitination  negative regulation of epidermal growth factor receptor signaling pathway  regulation of cell proliferation  retrograde transport, endosome to Golgi  proteasome-mediated ubiquitin-dependent protein catabolic process  ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway  metal ion binding  ubiquitin protein ligase activity  ubiquitin protein ligase activity  protein K63-linked ubiquitination  protein K48-linked ubiquitination  cytoplasm protein quality control by the ubiquitin-proteasome system  
NDEx NetworkRNF126
Atlas of Cancer Signalling NetworkRNF126
Wikipedia pathwaysRNF126
Orthology - Evolution
OrthoDB55658
GeneTree (enSembl)ENSG00000070423
Phylogenetic Trees/Animal Genes : TreeFamRNF126
HOGENOMQ9BV68
Homologs : HomoloGeneRNF126
Homology/Alignments : Family Browser (UCSC)RNF126
Gene fusions - Rearrangements
Fusion : MitelmanMKNK2/RNF126 [19p13.3/19p13.3] &nbsp[t(19;19)(p13;p13)]  
Fusion : MitelmanOAZ1/RNF126 [19p13.3/19p13.3] &nbsp[t(19;19)(p13;p13)]  
Fusion : MitelmanSHC2/RNF126 [19p13.3/19p13.3] &nbsp[t(19;19)(p13;p13)]  
Fusion PortalMKNK2 19p13.3 RNF126 19p13.3 LAML
Fusion PortalSHC2 19p13.3 RNF126 19p13.3 SKCM
Fusion : QuiverRNF126
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRNF126 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RNF126
dbVarRNF126
ClinVarRNF126
1000_GenomesRNF126 
Exome Variant ServerRNF126
ExAC (Exome Aggregation Consortium)ENSG00000070423
GNOMAD BrowserENSG00000070423
Varsome BrowserRNF126
Genetic variants : HAPMAP55658
Genomic Variants (DGV)RNF126 [DGVbeta]
DECIPHERRNF126 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRNF126 
Mutations
ICGC Data PortalRNF126 
TCGA Data PortalRNF126 
Broad Tumor PortalRNF126
OASIS PortalRNF126 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRNF126  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRNF126
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RNF126
DgiDB (Drug Gene Interaction Database)RNF126
DoCM (Curated mutations)RNF126 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RNF126 (select a term)
intoGenRNF126
Cancer3DRNF126(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM615177   
Orphanet
DisGeNETRNF126
MedgenRNF126
Genetic Testing Registry RNF126
NextProtQ9BV68 [Medical]
TSGene55658
GENETestsRNF126
Target ValidationRNF126
Huge Navigator RNF126 [HugePedia]
snp3D : Map Gene to Disease55658
BioCentury BCIQRNF126
ClinGenRNF126
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55658
Chemical/Pharm GKB GenePA134876469
Clinical trialRNF126
Miscellaneous
canSAR (ICR)RNF126 (select the gene name)
DataMed IndexRNF126
Probes
Litterature
PubMed39 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRNF126
EVEXRNF126
GoPubMedRNF126
iHOPRNF126
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Jan 17 18:35:36 CET 2019

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