SIRT2 (sirtuin 2)

1. Identity

Alias_names
General Information
sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 2
sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae)
Other aliasSIR2
SIR2L2
HGNC (Hugo) SIRT2
LocusID (NCBI) 22933
Atlas_Id 46529
Location 19q13.2  [Link to chromosome band 19q13]
Location_base_pair Starts at 38878555 and ends at 38899862 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CLSTN3 (12p13.31) / SIRT2 (19q13.2)HNRNPL (19q13.2) / SIRT2 (19q13.2)PLD3 (19q13.2) / SIRT2 (19q13.2)
SIRT2 (19q13.2) / TRIM63 (1p36.11)HNRNPL 19q13.2 / SIRT2 19q13.2PLD3 19q13.2 / SIRT2 19q13.2

2. DNA/RNA

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  HNRNPL/SIRT2 (19q13)
PLD3/SIRT2 (19q13)


3. External links

Nomenclature
HGNC (Hugo)SIRT2   10886
Cards
Entrez_Gene (NCBI)SIRT2  22933  sirtuin 2
AliasesSIR2; SIR2L; SIR2L2
GeneCards (Weizmann)SIRT2
Ensembl hg19 (Hinxton)ENSG00000068903 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000068903 [Gene_View] &nbspENSG00000068903 [Sequence]  chr19:38878555-38899862 [Contig_View]  SIRT2 [Vega]
ICGC DataPortalENSG00000068903
TCGA cBioPortalSIRT2
AceView (NCBI)SIRT2
Genatlas (Paris)SIRT2
WikiGenes22933
SOURCE (Princeton)SIRT2
Genetics Home Reference (NIH)SIRT2
Genomic and cartography
GoldenPath hg38 (UCSC)SIRT2  -     chr19:38878555-38899862 -  19q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SIRT2  -     19q13.2   [Description]    (hg19-Feb_2009)
EnsemblSIRT2 - 19q13.2 [CytoView hg19]  SIRT2 - 19q13.2 [CytoView hg38]
Mapping of homologs : NCBISIRT2 [Mapview hg19]  SIRT2 [Mapview hg38]
OMIM604480   
Gene and transcription
Genbank (Entrez)AB009274 AF083107 AF095714 AF131800 AF160214
RefSeq transcript (Entrez)NM_001193286 NM_012237 NM_030593
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SIRT2
Cluster EST : UnigeneHs.466693 [ NCBI ]
CGAP (NCI)Hs.466693
Alternative Splicing GalleryENSG00000068903
Gene ExpressionSIRT2 [ NCBI-GEO ]   SIRT2 [ EBI - ARRAY_EXPRESS ]   SIRT2 [ SEEK ]   SIRT2 [ MEM ]
Gene Expression Viewer (FireBrowse)SIRT2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets] &nbsp [Normal Tissue Atlas] &nbsp[carcinoma Classsification] &nbsp[NCI60]
GenevestigatorExpression in : [tissues] &nbsp[cell-lines] &nbsp[cancer] &nbsp[perturbations] &nbsp
BioGPS (Tissue expression)22933
GTEX Portal (Tissue expression)SIRT2
Human Protein AtlasENSG00000068903-SIRT2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IXJ6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IXJ6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IXJ6
Splice isoforms : SwissVarQ8IXJ6
PhosPhoSitePlusQ8IXJ6
Domaine pattern : Prosite (Expaxy)SIRTUIN (PS50305)   
Domains : Interpro (EBI)DHS-like_NAD/FAD-binding_dom    Sirtuin    Sirtuin_cat_small_dom_sf    Sirtuin_class_I    Ssirtuin_cat_dom   
Domain families : Pfam (Sanger)SIR2 (PF02146)   
Domain families : Pfam (NCBI)pfam02146   
Conserved Domain (NCBI)SIRT2
DMDM Disease mutations22933
Blocks (Seattle)SIRT2
PDB (RSDB)1J8F    3ZGO    3ZGV    4L3O    4R8M    4RMG    4RMH    4RMI    4RMJ    4X3O    4X3P    4Y6L    4Y6O    4Y6Q    5D7O    5D7P    5D7Q    5DY4    5DY5    5FYQ    5G4C    5MAR    5MAT    5Y5N   
PDB Europe1J8F    3ZGO    3ZGV    4L3O    4R8M    4RMG    4RMH    4RMI    4RMJ    4X3O    4X3P    4Y6L    4Y6O    4Y6Q    5D7O    5D7P    5D7Q    5DY4    5DY5    5FYQ    5G4C    5MAR    5MAT    5Y5N   
PDB (PDBSum)1J8F    3ZGO    3ZGV    4L3O    4R8M    4RMG    4RMH    4RMI    4RMJ    4X3O    4X3P    4Y6L    4Y6O    4Y6Q    5D7O    5D7P    5D7Q    5DY4    5DY5    5FYQ    5G4C    5MAR    5MAT    5Y5N   
PDB (IMB)1J8F    3ZGO    3ZGV    4L3O    4R8M    4RMG    4RMH    4RMI    4RMJ    4X3O    4X3P    4Y6L    4Y6O    4Y6Q    5D7O    5D7P    5D7Q    5DY4    5DY5    5FYQ    5G4C    5MAR    5MAT    5Y5N   
Structural Biology KnowledgeBase1J8F    3ZGO    3ZGV    4L3O    4R8M    4RMG    4RMH    4RMI    4RMJ    4X3O    4X3P    4Y6L    4Y6O    4Y6Q    5D7O    5D7P    5D7Q    5DY4    5DY5    5FYQ    5G4C    5MAR    5MAT    5Y5N   
SCOP (Structural Classification of Proteins)1J8F    3ZGO    3ZGV    4L3O    4R8M    4RMG    4RMH    4RMI    4RMJ    4X3O    4X3P    4Y6L    4Y6O    4Y6Q    5D7O    5D7P    5D7Q    5DY4    5DY5    5FYQ    5G4C    5MAR    5MAT    5Y5N   
CATH (Classification of proteins structures)1J8F    3ZGO    3ZGV    4L3O    4R8M    4RMG    4RMH    4RMI    4RMJ    4X3O    4X3P    4Y6L    4Y6O    4Y6Q    5D7O    5D7P    5D7Q    5DY4    5DY5    5FYQ    5G4C    5MAR    5MAT    5Y5N   
SuperfamilyQ8IXJ6
Human Protein Atlas [tissue]ENSG00000068903-SIRT2 [tissue]
Peptide AtlasQ8IXJ6
HPRD10377
IPIIPI00179109   IPI00382551   IPI00472047   IPI00382553   IPI00872344   IPI00880199   IPI00880041   IPI00877886   IPI00878091   IPI00940216   IPI00878416   IPI00878248   IPI00878807   
Protein Interaction databases
DIP (DOE-UCLA)Q8IXJ6
IntAct (EBI)Q8IXJ6
FunCoupENSG00000068903
BioGRIDSIRT2
STRING (EMBL)SIRT2
ZODIACSIRT2
Ontologies - Pathways
QuickGOQ8IXJ6
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  negative regulation of transcription by RNA polymerase II  chromatin silencing at rDNA  chromosome, telomeric region  chromatin binding  NAD+ ADP-ribosyltransferase activity  histone deacetylase activity  protein binding  nucleus  chromatin silencing complex  chromosome  nuclear heterochromatin  nucleolus  cytoplasm  mitochondrion  centrosome  centriole  spindle  cytosol  microtubule  plasma membrane  chromatin silencing  chromatin silencing at telomere  protein ADP-ribosylation  protein ADP-ribosylation  protein deacetylation  protein deacetylation  autophagy  regulation of exit from mitosis  transcription factor binding  transcription factor binding  zinc ion binding  negative regulation of cell proliferation  negative regulation of autophagy  negative regulation of peptidyl-threonine phosphorylation  phosphatidylinositol 3-kinase signaling  gene silencing  histone deacetylation  NAD-dependent histone deacetylase activity  NAD-dependent histone deacetylase activity  substantia nigra development  myelination in peripheral nervous system  growth cone  midbody  regulation of myelination  positive regulation of proteasomal ubiquitin-dependent protein catabolic process  paranodal junction  paranode region of axon  protein deacetylase activity  protein deacetylase activity  cellular response to oxidative stress  NAD-dependent protein deacetylase activity  NAD-dependent protein deacetylase activity  peptidyl-lysine deacetylation  histone acetyltransferase binding  cellular response to hepatocyte growth factor stimulus  negative regulation of protein catabolic process  regulation of phosphorylation  histone deacetylase binding  tubulin deacetylase activity  ubiquitin binding  proteasome-mediated ubiquitin-dependent protein catabolic process  perikaryon  myelin sheath  lateral loop  Schmidt-Lanterman incisure  positive regulation of DNA binding  protein kinase B signaling  juxtaparanode region of axon  cellular lipid catabolic process  innate immune response  negative regulation of fat cell differentiation  positive regulation of meiotic nuclear division  negative regulation of striated muscle tissue development  negative regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  NAD-dependent histone deacetylase activity (H4-K16 specific)  hepatocyte growth factor receptor signaling pathway  perinuclear region of cytoplasm  cell division  meiotic cell cycle  regulation of cell cycle  response to redox state  positive regulation of cell division  positive regulation of attachment of spindle microtubules to kinetochore  negative regulation of transcription from RNA polymerase II promoter in response to hypoxia  cellular response to caloric restriction  NAD+ binding  NAD+ binding  negative regulation of oligodendrocyte progenitor proliferation  histone H3 deacetylation  histone H4 deacetylation  cellular response to molecule of bacterial origin  cellular response to hypoxia  cellular response to epinephrine stimulus  mitotic spindle  meiotic spindle  tubulin deacetylation  tubulin deacetylation  tubulin deacetylation  glial cell projection  positive regulation of execution phase of apoptosis  positive regulation of oocyte maturation  negative regulation of NLRP3 inflammasome complex assembly  negative regulation of defense response to bacterium  negative regulation of reactive oxygen species metabolic process  positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  negative regulation of transcription by RNA polymerase II  chromatin silencing at rDNA  chromosome, telomeric region  chromatin binding  NAD+ ADP-ribosyltransferase activity  histone deacetylase activity  protein binding  nucleus  chromatin silencing complex  chromosome  nuclear heterochromatin  nucleolus  cytoplasm  mitochondrion  centrosome  centriole  spindle  cytosol  microtubule  plasma membrane  chromatin silencing  chromatin silencing at telomere  protein ADP-ribosylation  protein ADP-ribosylation  protein deacetylation  protein deacetylation  autophagy  regulation of exit from mitosis  transcription factor binding  transcription factor binding  zinc ion binding  negative regulation of cell proliferation  negative regulation of autophagy  negative regulation of peptidyl-threonine phosphorylation  phosphatidylinositol 3-kinase signaling  gene silencing  histone deacetylation  NAD-dependent histone deacetylase activity  NAD-dependent histone deacetylase activity  substantia nigra development  myelination in peripheral nervous system  growth cone  midbody  regulation of myelination  positive regulation of proteasomal ubiquitin-dependent protein catabolic process  paranodal junction  paranode region of axon  protein deacetylase activity  protein deacetylase activity  cellular response to oxidative stress  NAD-dependent protein deacetylase activity  NAD-dependent protein deacetylase activity  peptidyl-lysine deacetylation  histone acetyltransferase binding  cellular response to hepatocyte growth factor stimulus  negative regulation of protein catabolic process  regulation of phosphorylation  histone deacetylase binding  tubulin deacetylase activity  ubiquitin binding  proteasome-mediated ubiquitin-dependent protein catabolic process  perikaryon  myelin sheath  lateral loop  Schmidt-Lanterman incisure  positive regulation of DNA binding  protein kinase B signaling  juxtaparanode region of axon  cellular lipid catabolic process  innate immune response  negative regulation of fat cell differentiation  positive regulation of meiotic nuclear division  negative regulation of striated muscle tissue development  negative regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  NAD-dependent histone deacetylase activity (H4-K16 specific)  hepatocyte growth factor receptor signaling pathway  perinuclear region of cytoplasm  cell division  meiotic cell cycle  regulation of cell cycle  response to redox state  positive regulation of cell division  positive regulation of attachment of spindle microtubules to kinetochore  negative regulation of transcription from RNA polymerase II promoter in response to hypoxia  cellular response to caloric restriction  NAD+ binding  NAD+ binding  negative regulation of oligodendrocyte progenitor proliferation  histone H3 deacetylation  histone H4 deacetylation  cellular response to molecule of bacterial origin  cellular response to hypoxia  cellular response to epinephrine stimulus  mitotic spindle  meiotic spindle  tubulin deacetylation  tubulin deacetylation  tubulin deacetylation  glial cell projection  positive regulation of execution phase of apoptosis  positive regulation of oocyte maturation  negative regulation of NLRP3 inflammasome complex assembly  negative regulation of defense response to bacterium  negative regulation of reactive oxygen species metabolic process  positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia  
NDEx NetworkSIRT2
Atlas of Cancer Signalling NetworkSIRT2
Wikipedia pathwaysSIRT2
Orthology - Evolution
OrthoDB22933
GeneTree (enSembl)ENSG00000068903
Phylogenetic Trees/Animal Genes : TreeFamSIRT2
HOGENOMQ8IXJ6
Homologs : HomoloGeneSIRT2
Homology/Alignments : Family Browser (UCSC)SIRT2
Gene fusions - Rearrangements
Fusion : MitelmanHNRNPL/SIRT2 [19q13.2/19q13.2] &nbsp[t(19;19)(q13;q13)]  
Fusion : MitelmanPLD3/SIRT2 [19q13.2/19q13.2] &nbsp[t(19;19)(q13;q13)]  
Fusion PortalHNRNPL 19q13.2 SIRT2 19q13.2 KIRC
Fusion PortalPLD3 19q13.2 SIRT2 19q13.2 BRCA
Fusion : QuiverSIRT2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSIRT2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SIRT2
dbVarSIRT2
ClinVarSIRT2
1000_GenomesSIRT2 
Exome Variant ServerSIRT2
ExAC (Exome Aggregation Consortium)ENSG00000068903
GNOMAD BrowserENSG00000068903
Varsome BrowserSIRT2
Genetic variants : HAPMAP22933
Genomic Variants (DGV)SIRT2 [DGVbeta]
DECIPHERSIRT2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSIRT2 
Mutations
ICGC Data PortalSIRT2 
TCGA Data PortalSIRT2 
Broad Tumor PortalSIRT2
OASIS PortalSIRT2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSIRT2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSIRT2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SIRT2
DgiDB (Drug Gene Interaction Database)SIRT2
DoCM (Curated mutations)SIRT2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SIRT2 (select a term)
intoGenSIRT2
Cancer3DSIRT2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604480   
Orphanet
DisGeNETSIRT2
MedgenSIRT2
Genetic Testing Registry SIRT2
NextProtQ8IXJ6 [Medical]
TSGene22933
GENETestsSIRT2
Target ValidationSIRT2
Huge Navigator SIRT2 [HugePedia]
snp3D : Map Gene to Disease22933
BioCentury BCIQSIRT2
ClinGenSIRT2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD22933
Chemical/Pharm GKB GenePA35786
Clinical trialSIRT2
Miscellaneous
canSAR (ICR)SIRT2 (select the gene name)
DataMed IndexSIRT2
Probes
Litterature
PubMed180 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSIRT2
EVEXSIRT2
GoPubMedSIRT2
iHOPSIRT2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Jan 17 18:38:06 CET 2019

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