STRN4 (striatin 4)

1. Identity

Alias_names
General Information
Alias_symbol (synonym)zinedin
ZIN
PPP2R6C
Other alias
HGNC (Hugo) STRN4
LocusID (NCBI) 29888
Atlas_Id 54059
Location 19q13.32  [Link to chromosome band 19q13]
Location_base_pair Starts at 46719511 and ends at 46746463 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
IKBKB (8p11.21) / STRN4 (19q13.32)RPL11 (1p36.11) / STRN4 (19q13.32)STRN4 (19q13.32) / AP2S1 (19q13.32)
STRN4 (19q13.32) / TECR (19p13.12)STRN4 (19q13.32) / TNRC6A (16p12.1)

2. DNA/RNA

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  Prostate tumors: an overview
t(19;19)(p13;q13) STRN4/TECR

3. External links

Nomenclature
HGNC (Hugo)STRN4   15721
Cards
Entrez_Gene (NCBI)STRN4  29888  striatin 4
AliasesPPP2R6C; ZIN; zinedin
GeneCards (Weizmann)STRN4
Ensembl hg19 (Hinxton)ENSG00000090372 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000090372 [Gene_View] &nbspENSG00000090372 [Sequence]  chr19:46719511-46746463 [Contig_View]  STRN4 [Vega]
ICGC DataPortalENSG00000090372
TCGA cBioPortalSTRN4
AceView (NCBI)STRN4
Genatlas (Paris)STRN4
WikiGenes29888
SOURCE (Princeton)STRN4
Genetics Home Reference (NIH)STRN4
Genomic and cartography
GoldenPath hg38 (UCSC)STRN4  -     chr19:46719511-46746463 -  19q13.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)STRN4  -     19q13.32   [Description]    (hg19-Feb_2009)
EnsemblSTRN4 - 19q13.32 [CytoView hg19]  STRN4 - 19q13.32 [CytoView hg38]
Mapping of homologs : NCBISTRN4 [Mapview hg19]  STRN4 [Mapview hg38]
OMIM614767   
Gene and transcription
Genbank (Entrez)AB209003 AF212940 AK055312 AK056294 AK092913
RefSeq transcript (Entrez)NM_001039877 NM_013403
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)STRN4
Cluster EST : UnigeneHs.631590 [ NCBI ]
CGAP (NCI)Hs.631590
Alternative Splicing GalleryENSG00000090372
Gene ExpressionSTRN4 [ NCBI-GEO ]   STRN4 [ EBI - ARRAY_EXPRESS ]   STRN4 [ SEEK ]   STRN4 [ MEM ]
Gene Expression Viewer (FireBrowse)STRN4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets] &nbsp [Normal Tissue Atlas] &nbsp[carcinoma Classsification] &nbsp[NCI60]
GenevestigatorExpression in : [tissues] &nbsp[cell-lines] &nbsp[cancer] &nbsp[perturbations] &nbsp
BioGPS (Tissue expression)29888
GTEX Portal (Tissue expression)STRN4
Human Protein AtlasENSG00000090372-STRN4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NRL3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NRL3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NRL3
Splice isoforms : SwissVarQ9NRL3
PhosPhoSitePlusQ9NRL3
Domaine pattern : Prosite (Expaxy)WD_REPEATS_1 (PS00678)    WD_REPEATS_2 (PS50082)    WD_REPEATS_REGION (PS50294)   
Domains : Interpro (EBI)G-protein_beta_WD-40_rep    Striatin_N    WD40/YVTN_repeat-like_dom_sf    WD40_repeat    WD40_repeat_CS    WD40_repeat_dom    WD40_repeat_dom_sf   
Domain families : Pfam (Sanger)Striatin (PF08232)    WD40 (PF00400)   
Domain families : Pfam (NCBI)pfam08232    pfam00400   
Domain families : Smart (EMBL)WD40 (SM00320)  
Conserved Domain (NCBI)STRN4
DMDM Disease mutations29888
Blocks (Seattle)STRN4
SuperfamilyQ9NRL3
Human Protein Atlas [tissue]ENSG00000090372-STRN4 [tissue]
Peptide AtlasQ9NRL3
HPRD18125
IPIIPI00003016   IPI00909427   IPI01010080   IPI00741970   
Protein Interaction databases
DIP (DOE-UCLA)Q9NRL3
IntAct (EBI)Q9NRL3
FunCoupENSG00000090372
BioGRIDSTRN4
STRING (EMBL)STRN4
ZODIACSTRN4
Ontologies - Pathways
QuickGOQ9NRL3
Ontology : AmiGOprotein binding  calmodulin binding  calmodulin binding  cytoplasm  biological_process  membrane  dendrite  dendritic spine  protein-containing complex binding  protein-containing complex binding  protein phosphatase 2A binding  protein phosphatase 2A binding  armadillo repeat domain binding  armadillo repeat domain binding  FAR/SIN/STRIPAK complex  
Ontology : EGO-EBIprotein binding  calmodulin binding  calmodulin binding  cytoplasm  biological_process  membrane  dendrite  dendritic spine  protein-containing complex binding  protein-containing complex binding  protein phosphatase 2A binding  protein phosphatase 2A binding  armadillo repeat domain binding  armadillo repeat domain binding  FAR/SIN/STRIPAK complex  
NDEx NetworkSTRN4
Atlas of Cancer Signalling NetworkSTRN4
Wikipedia pathwaysSTRN4
Orthology - Evolution
OrthoDB29888
GeneTree (enSembl)ENSG00000090372
Phylogenetic Trees/Animal Genes : TreeFamSTRN4
HOGENOMQ9NRL3
Homologs : HomoloGeneSTRN4
Homology/Alignments : Family Browser (UCSC)STRN4
Gene fusions - Rearrangements
Fusion : MitelmanSTRN4/TECR [19q13.32/19p13.12] &nbsp
Fusion : QuiverSTRN4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSTRN4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)STRN4
dbVarSTRN4
ClinVarSTRN4
1000_GenomesSTRN4 
Exome Variant ServerSTRN4
ExAC (Exome Aggregation Consortium)ENSG00000090372
GNOMAD BrowserENSG00000090372
Varsome BrowserSTRN4
Genetic variants : HAPMAP29888
Genomic Variants (DGV)STRN4 [DGVbeta]
DECIPHERSTRN4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSTRN4 
Mutations
ICGC Data PortalSTRN4 
TCGA Data PortalSTRN4 
Broad Tumor PortalSTRN4
OASIS PortalSTRN4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSTRN4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSTRN4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch STRN4
DgiDB (Drug Gene Interaction Database)STRN4
DoCM (Curated mutations)STRN4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)STRN4 (select a term)
intoGenSTRN4
Cancer3DSTRN4(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM614767   
Orphanet
DisGeNETSTRN4
MedgenSTRN4
Genetic Testing Registry STRN4
NextProtQ9NRL3 [Medical]
TSGene29888
GENETestsSTRN4
Target ValidationSTRN4
Huge Navigator STRN4 [HugePedia]
snp3D : Map Gene to Disease29888
BioCentury BCIQSTRN4
ClinGenSTRN4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD29888
Chemical/Pharm GKB GenePA134863218
Clinical trialSTRN4
Miscellaneous
canSAR (ICR)STRN4 (select the gene name)
DataMed IndexSTRN4
Probes
Litterature
PubMed43 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSTRN4
EVEXSTRN4
GoPubMedSTRN4
iHOPSTRN4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Jan 17 18:40:49 CET 2019

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