TFG (TRK-fused gene)

Written2004-09Masanori Hisaoka, Hiroshi Hashimoto
Department of Pathology & Oncology, School of Medicine, University of Occupational & Environmental Health, Japan

(Note : for Links provided by Atlas : click)

1. Identity

Alias_symbol (synonym)
General Information
Other alias
LocusID (NCBI) 10342
Atlas_Id 281
Location 3q12.2  [Link to chromosome band 3q12]
Location_base_pair Starts at 100709331 and ends at 100748967 bp from pter ( according to hg19-Feb_2009)  [Mapping TFG.png]
  Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ADGRG7 (3q12.2) / TFG (3q12.2)ALK (2p23.2) / TFG (3q12.2)MET (7q31.2) / TFG (3q12.2)
NR4A3 (9q22.33) / TFG (3q12.2)NTRK1 (1q23.1) / TFG (3q12.2)PCNP (3q12.3) / TFG (3q12.2)
PRDM2 (1p36.21) / TFG (3q12.2)TFG (3q12.2) / ADGRG7 (3q12.2)TFG (3q12.2) / ALK (2p23.2)
TFG (3q12.2) / LINC01545 (Xp11.23)TFG (3q12.2) / MET (7q31.2)TFG (3q12.2) / NR4A3 (9q22.33)
TFG (3q12.2) / NR4A3 (9q31.1)TFG (3q12.2) / NTRK1 (1q23.1)TFG (3q12.2) / ROS1 (6q22.1)
TFG (3q12.2) / TRPC5 (Xq23)TFG (3q12.2) / ZBTB11 (3q12.3)


Description 39.51 kbp
Transcription 8 exons; 1948 bp mRNA.
Pseudogene one (NB5M_HUMAN.Human.2.v2.chr1C.mbl.220)

3. Protein

Description 400-amino acid protein with a putative N-terminal coiled-coil structure and an SPYGQ-rich region similar to N-terminal parts of EWSR1 and FUS.
Expression Ubiquitously expressed.
Localisation Not examined (TFG-ALK fusion protein is localized in cytoplasm).
Function unknown
Homology Homologous to murine Tfg.

4. Implicated in

Entity Anaplastic large cell lymphoma
Cytogenetics t(2;3)(p23;q21)
Hybrid/Mutated Gene TFG-ALK
Abnormal Protein TFG-ALK(S)(85 kD), TFG-ALK(L)(97 kD), TFG-ALK(XL)(113 kD)
Entity Thyroid papillary carcinoma
Cytogenetics t(1;3)(q21;q11)
Hybrid/Mutated Gene TFG-NTRK1
Abnormal Protein TFG-NTRK1
Entity Extraskeletal myxoid chondrosarcoma
Hybrid/Mutated Gene TFG-NR4A3

5. Breakpoints


6. Bibliography

The DNA rearrangement that generates the TRK-T3 oncogene involves a novel gene on chromosome 3 whose product has a potential coiled-coil domain.
Greco A, Mariani C, Miranda C, Lupas A, Pagliardini S, Pomati M, Pierotti MA
Molecular and cellular biology. 1995 ; 15 (11) : 6118-6127.
PMID 7565764
Diversity of genomic breakpoints in TFG-ALK translocations in anaplastic large cell lymphomas: identification of a new TFG-ALK(XL) chimeric gene with transforming activity.
Hern´ndez L, Beà S, Bellosillo B, Pinyol M, Falini B, Carbone A, Ott G, Rosenwald A, Fern´ndez A, Pulford K, Mason D, Morris SW, Santos E, Campo E
The American journal of pathology. 2002 ; 160 (4) : 1487-1494.
PMID 11943732
TFG is a novel fusion partner of NOR1 in extraskeletal myxoid chondrosarcoma.
Hisaoka M, Ishida T, Imamura T, Hashimoto H
Genes, chromosomes & cancer. 2004 ; 40 (4) : 325-328.
PMID 15188455
Characterization and chromosomal mapping of the human TFG gene involved in thyroid carcinoma.
Mencinger M, Panagopoulos I, Andreasson P, Lassen C, Mitelman F, Aman P
Genomics. 1997 ; 41 (3) : 327-331.
PMID 9169129

7. Citation

This paper should be referenced as such :
Hisaoka, M ; Hashimoto, H
TFG (TRK-fused gene)
Atlas Genet Cytogenet Oncol Haematol. 2004;8(4):303-304.
Free journal version : [ pdf ]   [ DOI ]
On line version :

8. Other Leukemias implicated (Data extracted from papers in the Atlas) [ 6 ]

9. External links

HGNC (Hugo)TFG   11758
Entrez_Gene (NCBI)TFG  10342  TRK-fused gene
AliasesHMSNP; SPG57; TF6; TRKT3
GeneCards (Weizmann)TFG
Ensembl hg19 (Hinxton)ENSG00000114354 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000114354 [Gene_View] &nbspENSG00000114354 [Sequence]  chr3:100709331-100748967 [Contig_View]  TFG [Vega]
ICGC DataPortalENSG00000114354
TCGA cBioPortalTFG
Genatlas (Paris)TFG
SOURCE (Princeton)TFG
Genetics Home Reference (NIH)TFG
Genomic and cartography
GoldenPath hg38 (UCSC)TFG  -     chr3:100709331-100748967 +  3q12.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TFG  -     3q12.2   [Description]    (hg19-Feb_2009)
EnsemblTFG - 3q12.2 [CytoView hg19]  TFG - 3q12.2 [CytoView hg38]
Mapping of homologs : NCBITFG [Mapview hg19]  TFG [Mapview hg38]
OMIM602498   604484   615658   
Gene and transcription
Genbank (Entrez)AB097040 AB097041 AB731569 AB731570 AK093456
RefSeq transcript (Entrez)NM_001007565 NM_001195478 NM_001195479 NM_006070
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TFG
Cluster EST : UnigeneHs.518123 [ NCBI ]
CGAP (NCI)Hs.518123
Alternative Splicing GalleryENSG00000114354
Gene ExpressionTFG [ NCBI-GEO ]   TFG [ EBI - ARRAY_EXPRESS ]   TFG [ SEEK ]   TFG [ MEM ]
Gene Expression Viewer (FireBrowse)TFG [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets] &nbsp [Normal Tissue Atlas] &nbsp[carcinoma Classsification] &nbsp[NCI60]
GenevestigatorExpression in : [tissues] &nbsp[cell-lines] &nbsp[cancer] &nbsp[perturbations] &nbsp
BioGPS (Tissue expression)10342
GTEX Portal (Tissue expression)TFG
Human Protein AtlasENSG00000114354-TFG [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92734   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92734  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92734
Splice isoforms : SwissVarQ92734
Domaine pattern : Prosite (Expaxy)PB1 (PS51745)   
Domains : Interpro (EBI)PB1_dom    PB1_TFG    TFG   
Domain families : Pfam (Sanger)PB1 (PF00564)   
Domain families : Pfam (NCBI)pfam00564   
Domain families : Smart (EMBL)PB1 (SM00666)  
Conserved Domain (NCBI)TFG
DMDM Disease mutations10342
Blocks (Seattle)TFG
Human Protein Atlas [tissue]ENSG00000114354-TFG [tissue]
Peptide AtlasQ92734
IPIIPI00294619   IPI00297452   IPI00788849   IPI00952872   IPI00790804   
Protein Interaction databases
IntAct (EBI)Q92734
Ontologies - Pathways
Ontology : AmiGOGolgi membrane  protein binding  cytoplasm  cytosol  ER to Golgi vesicle-mediated transport  identical protein binding  positive regulation of I-kappaB kinase/NF-kappaB signaling  COPII vesicle coating  endoplasmic reticulum exit site  
Ontology : EGO-EBIGolgi membrane  protein binding  cytoplasm  cytosol  ER to Golgi vesicle-mediated transport  identical protein binding  positive regulation of I-kappaB kinase/NF-kappaB signaling  COPII vesicle coating  endoplasmic reticulum exit site  
Pathways : KEGGPathways in cancer    Thyroid cancer   
REACTOMEQ92734 [protein]
REACTOME PathwaysR-HSA-204005 [pathway]   
NDEx NetworkTFG
Atlas of Cancer Signalling NetworkTFG
Wikipedia pathwaysTFG
Orthology - Evolution
GeneTree (enSembl)ENSG00000114354
Phylogenetic Trees/Animal Genes : TreeFamTFG
Homologs : HomoloGeneTFG
Homology/Alignments : Family Browser (UCSC)TFG
Gene fusions - Rearrangements
Fusion : MitelmanGPR128/3q12.2 [TFG/dup(3)(q12q12)] &nbsp
Fusion : MitelmanMET/TFG [7q31.2/3q12.2] &nbsp[t(3;7)(q12;q31)]  
Fusion : MitelmanTFG/ALK [3q12.2/2p23.2] &nbsp[t(2;3)(p23;q12)]  
Fusion : MitelmanTFG/GPR128 [3q12.2/t(3;3)(q12;q12)] &nbsp
Fusion : MitelmanTFG/MET [3q12.2/7q31.2] &nbsp[t(3;7)(q12;q31)]  
Fusion : MitelmanTFG/NR4A3 [3q12.2/9q22.33] &nbsp[t(3;9)(q12;q31)]  
Fusion : MitelmanTFG/NTRK1 [3q12.2/1q23.1] &nbsp[t(1;3)(q23;q12)]  
Fusion : MitelmanTFG/ROS1 [3q12.2/6q22.1] &nbsp[t(3;6)(q12;q22)]  
Fusion : COSMICNTRK1 [TFG]  -  1339 []  
Fusion : COSMICTFG [ALK]  -  424 [425]  [fusion_426]  [fusion_428]  [fusion_429]  [fusion_430]  [fusion_432]  [fusion_433]  
Fusion : COSMICTFG [NR4A3]  -  1187 [610]  
Fusion : COSMICTFG [NTRK1]  -  1328 [1331]  [fusion_1337]  
Fusion PortalMET 7q31.2 TFG 3q12.2 THCA
Fusion PortalTFG 3q12.2 MET 7q31.2 THCA
Fusion PortalTFG 3q12.2 NTRK1 1q23.1 THCA
Fusion : TICdbTFG [3q12.2]  -  ALK [2p23.2]
Fusion : TICdbTFG [3q12.2]  -  NR4A3 [9q22.33]
Fusion : TICdbTFG [3q12.2]  -  NTRK1 [1q23.1]
Fusion : QuiverTFG
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTFG [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TFG
Exome Variant ServerTFG
ExAC (Exome Aggregation Consortium)ENSG00000114354
GNOMAD BrowserENSG00000114354
Varsome BrowserTFG
Genetic variants : HAPMAP10342
Genomic Variants (DGV)TFG [DGVbeta]
DECIPHERTFG [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTFG 
ICGC Data PortalTFG 
TCGA Data PortalTFG 
Broad Tumor PortalTFG
OASIS PortalTFG [ Somatic mutations - Copy number]
Cancer Gene: CensusTFG 
Somatic Mutations in Cancer : COSMICTFG  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTFG
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TFG
DgiDB (Drug Gene Interaction Database)TFG
DoCM (Curated mutations)TFG (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TFG (select a term)
NCG5 (London)TFG
Cancer3DTFG(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
OMIM602498    604484    615658   
Orphanet905    18668    23317    23243    11978   
Genetic Testing Registry TFG
NextProtQ92734 [Medical]
Target ValidationTFG
Huge Navigator TFG [HugePedia]
snp3D : Map Gene to Disease10342
BioCentury BCIQTFG
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10342
Chemical/Pharm GKB GenePA36473
Clinical trialTFG
canSAR (ICR)TFG (select the gene name)
DataMed IndexTFG
PubMed74 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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