t(2;8)(q35;p11) FN1/FGFR1

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Written08-2018Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

1. Identity

Atlas_Id 105530
Phylum Soft Tissues: Soft Tissues::
WHO/OMS Classification Soft Tissues
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

2. Clinics and Pathology

Disease Soft Tissues: Mesenchymal tumor, special type

3. Genes involved and Proteins

Gene NameFN1
Location 2q35

Gene NameFGFR1
Location 8p11.23

4. Bibliography

Identification of a novel FN1-FGFR1 genetic fusion as a frequent event in phosphaturic mesenchymal tumour
Lee JC, Jeng YM, Su SY, Wu CT, Tsai KS, Lee CH, Lin CY, Carter JM, Huang JW, Chen SH, Shih SR, Mariño-Enríquez A, Chen CC, Folpe AL, Chang YL, Liang CW
J Pathol 2015 Mar;235(4):539-45
PMID 25319834
Characterization of FN1-FGFR1 and novel FN1-FGF1 fusion genes in a large series of phosphaturic mesenchymal tumors
Lee JC, Su SY, Changou CA, Yang RS, Tsai KS, Collins MT, Orwoll ES, Lin CY, Chen SH, Shih SR, Lee CH, Oda Y, Billings SD, Li CF, Nielsen GP, Konishi E, Petersson F, Carpenter TO, Sittampalam K, Huang HY, Folpe AL
Mod Pathol 2016 Nov;29(11):1335-1346
PMID 27443518

5. Translocations implicated (Data extracted from papers in the Atlas)

 t(2;8)(q35;p11) FN1/FGFR1

6. External links

Mitelman database t(2;8)(q35;p11) [CaseList]     t(2;8)(q35;p11) [Transloc - MCList]   FN1/FGFR1 Fusion - MCList]
COSMIC[ FN1 ]   [ FGFR1 ]
arrayMap arrayMap ((UZH-SIB Zurich)   [auto + random 100 samples .. if exist ]   [tabulated segments]
Disease databaset(2;8)(q35;p11) FN1/FGFR1
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 28 16:34:20 CET 2018

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