t(10;17)(q23;p13) YWHAE/NUTM2A

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Written08-2018Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

1. Identity

Atlas_Id 100402
Phylum Female organs: Uterus::
WHO/OMS Classification Female organs
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

2. Clinics and Pathology

Disease Uterus: Endometrial stromal sarcoma

3. Genes involved and Proteins

Gene NameYWHAE
Location 17p13.3

Gene NameNUTM2A
Location 10q23.2

4. Bibliography

14-3-3 fusion oncogenes in high-grade endometrial stromal sarcoma
Lee CH, Ou WB, Mariño-Enriquez A, Zhu M, Mayeda M, Wang Y, Guo X, Brunner AL, Amant F, French CA, West RB, McAlpine JN, Gilks CB, Yaffe MB, Prentice LM, McPherson A, Jones SJ, Marra MA, Shah SP, van de Rijn M, Huntsman DG, Dal Cin P, Debiec-Rychter M, Nucci MR, Fletcher JA
Proc Natl Acad Sci U S A 2012 Jan 17;109(3):929-34
PMID 22223660
The clinicopathologic features of YWHAE-FAM22 endometrial stromal sarcomas: a histologically high-grade and clinically aggressive tumor
Lee CH, Mariño-Enriquez A, Ou W, Zhu M, Ali RH, Chiang S, Amant F, Gilks CB, van de Rijn M, Oliva E, Debiec-Rychter M, Dal Cin P, Fletcher JA, Nucci MR
Am J Surg Pathol 2012 May;36(5):641-53
PMID 22456610
YWHAE rearrangement identified by FISH and RT-PCR in endometrial stromal sarcomas: genetic and pathological correlations
Croce S, Hostein I, Ribeiro A, Garbay D, Velasco V, Stoeckle E, Guyon F, Floquet A, Neuville A, Coindre JM, MacGrogan G, Chibon F
Mod Pathol 2013 Oct;26(10):1390-400
PMID 23599159

5. Translocations implicated (Data extracted from papers in the Atlas)

 t(10;17)(q23;p13) YWHAE/NUTM2A

6. External links

Mitelman database t(10;17)(q23;p13) [CaseList]     t(10;17)(q23;p13) [Transloc - MCList]   YWHAE/NUTM2A Fusion - MCList]
arrayMap arrayMap ((UZH-SIB Zurich)   [auto + random 100 samples .. if exist ]   [tabulated segments]
Disease databaset(10;17)(q23;p13) YWHAE/NUTM2A
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 28 16:52:27 CET 2018

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