t(12;12)(q14;q15) MDM2/PPM1H

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Written08-2018Jean-Loup Huret, Philippe Dessen

(Note : for Links provided by Atlas : click)

1. Identity

Atlas_Id 101314
Phylum Nervous system: Central Nervous system::
WHO/OMS Classification Nervous system
Note Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation, go to  How to contribute

2. Clinics and Pathology

Disease Central Nervous system: Astrocytoma, grade III-IV/Glioblastoma

3. Genes involved and Proteins

Gene NameMDM2
Location 12q15

Gene NamePPM1H
Location 12q14.1

4. Bibliography

The integrated landscape of driver genomic alterations in glioblastoma
Frattini V, Trifonov V, Chan JM, Castano A, Lia M, Abate F, Keir ST, Ji AX, Zoppoli P, Niola F, Danussi C, Dolgalev I, Porrati P, Pellegatta S, Heguy A, Gupta G, Pisapia DJ, Canoll P, Bruce JN, McLendon RE, Yan H, Aldape K, Finocchiaro G, Mikkelsen T, Privé GG, Bigner DD, Lasorella A, Rabadan R, Iavarone A
Nat Genet 2013 Oct;45(10):1141-9
PMID 23917401
 

5. Translocations implicated (Data extracted from papers in the Atlas)

 t(12;12)(q14;q15) MDM2/PPM1H

6. External links

Mitelman database t(12;12)(q14;q15) [CaseList]     t(12;12)(q14;q15) [Transloc - MCList]   MDM2/PPM1H Fusion - MCList]
COSMIC[ MDM2 ]   [ PPM1H ]
arrayMap arrayMap ((UZH-SIB Zurich)   [auto + random 100 samples .. if exist ]   [tabulated segments]
 
 
Disease databaset(12;12)(q14;q15) MDM2/PPM1H
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed


© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 28 16:56:44 CET 2018

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